(Q27646778)

1

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Francesca Marino

2

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Zhiwei Chen

3

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Agustin O Pineda

4

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F Scott Mathews

5

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Enrico Di Cera

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

14 September 2007

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published in

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volume

282

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page(s)

27165-70

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issue

37

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cites work

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A structural perspective on enzymes activated by monovalent cations

21 January 2018

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Structure and interaction modes of thrombin

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Structural stability of human α-thrombin studied by disulfide reduction and scrambling

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Structural and evolutionary consequences of unpaired cysteines in trypsinogen.

21 January 2018

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Role of P225 and the C136-C201 disulfide bond in tissue plasminogen activator

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Expression and folding of recombinant bovine prethrombin-2 and its activation to thrombin

21 January 2018

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The prothrombin Denver patient has two different prothrombin point mutations resulting in Glu-300-->Lys and Glu-309-->Lys substitutions

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Gly319 --> arg substitution in the dysfunctional prothrombin Segovia

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Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases

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Conversion of trypsin into a Na(+)-activated enzyme.

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An allosteric switch controls the procoagulant and anticoagulant activities of thrombin

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Molecular dissection of Na+ binding to thrombin.

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Thrombin functions through its RGD sequence in a non-canonical conformation

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Identification of residues linked to the slow-->fast transition of thrombin

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Dissecting substrate recognition by thrombin using the inactive mutant S195A.

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Murine thrombin lacks Na+ activation but retains high catalytic activity.

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Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases

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Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR-1 or protein C.

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Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C.

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Processing of X-ray diffraction data collected in oscillation mode

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Stereochemical quality of protein structure coordinates

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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A hyperthermostable D-ribose-5-phosphate isomerase from Pyrococcus horikoshii characterization and three-dimensional structure

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Site-specific dissection of substrate recognition by thrombin

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Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates.

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Serpin structure, mechanism, and function

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Crystal structure of the thrombin mutant D221A/D222K: the Asp222:Arg187 ion-pair stabilizes the fast form.

21 January 2018

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The molecular environment of the Na+ binding site of thrombin

21 January 2018

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The Na+ binding channel of human coagulation proteases: novel insights on the structure and allosteric modulation revealed by molecular surface analysis.

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