(Q27667488)

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The Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled Oligomerization

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The Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled Oligomerization (English)

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Leishmania donovani

object named as

Leishmania donovani

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based on heuristic

inferred from title

Steven E Ealick

8

object named as

Steven E Ealick

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author name string

Jarrod B French

1

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Phillip A Yates

2

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D Radika Soysa

3

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Jan M Boitz

4

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Nicola S Carter

5

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Bailey Chang

6

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Buddy Ullman

7

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language of work or name

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publication date

10 June 2011

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Journal of Biological Chemistry

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286

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23

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20930-41

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1 reference

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Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design

1 reference

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Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase

1 reference

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1 reference

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Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase

1 reference

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The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase

1 reference

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Electrostatic stress in catalysis: Structure and mechanism of the enzyme orotidine monophosphate decarboxylase

1 reference

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Anatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog

1 reference

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Nucleoside hydrolase from Leishmania major. Cloning, expression, catalytic properties, transition state inhibitors, and the 2.5-å crystal structure

1 reference

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A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase

1 reference

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Crystal structure of orotate phosphoribosyltransferase

1 reference

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Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Protein secondary structure prediction based on position-specific scoring matrices

1 reference

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1 reference

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A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization

1 reference

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Leflunomide for the treatment of rheumatoid arthritis and autoimmunity

1 reference

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Glycosomes: parasites and the divergence of peroxisomal purpose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121495

20 March 2017

Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121495

20 March 2017

A proficient enzyme

1 reference

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1 reference

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The PredictProtein server

1 reference

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1 reference

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1 reference

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Adaptive responses to purine starvation in Leishmania donovani.

1 reference

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TriTrypDB: a functional genomic resource for the Trypanosomatidae

1 reference

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1 reference

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Purine and pyrimidine metabolism in Leishmania

1 reference

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Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway

1 reference

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Potential chemotherapeutic targets in the purine metabolism of parasites

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors.

1 reference

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https://pubmed.ncbi.nlm.nih.gov/21507942

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and Properties of Orotidine-5′-Phosphate Pyrophosphorylase and Orotidine-5′-Phosphate Decarboxylase from Bakers' Yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/21507942

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21507942

12 December 2020

based on heuristic

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1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.228213

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