(Q27671695)

7

0 references

Sophia Y Lunt

Sophia Y Lunt

25

0 references

Dimitrios Anastasiou

Dimitrios Anastasiou

1

0 references

Heather R Christofk

Heather R Christofk

30

0 references

Noel Southall

Noel Southall

21

0 references

Lewis C. Cantley

Lewis C Cantley

41

0 references

Brian P Fiske

Brian P Fiske

14

0 references

Christopher P Austin

31

Christopher P Austin

0 references

Craig J. Thomas

42

Craig J Thomas

0 references

Douglas S Auld

39

Douglas S Auld

0 references

Kyle R Brimacombe

23

Kyle R Brimacombe

0 references

Matthew G Vander Heiden

43

Matthew G Vander Heiden

0 references

Amanda P Skoumbourdis

19

Amanda P Skoumbourdis

0 references

Henrike Veith

20

Henrike Veith

0 references

William J Israelsen

3

William J Israelsen

0 references

Jian-kang Jiang

4

Jian-Kang Jiang

0 references

Bum Soo Hong

6

Bum Soo Hong

0 references

Svetoslav Dimov

8

Svetoslav Dimov

0 references

Katherine R Mattaini

12

Katherine R Mattaini

0 references

Christian M Metallo

13

Christian M Metallo

0 references

Scott Malstrom

16

Scott Malstrom

0 references

Tahsin N Khan

17

Tahsin M Khan

0 references

Katharine E Yen

27

Katharine E Yen

0 references

Kaiko Kunii

28

Kaiko Kunii

0 references

John M Asara

34

John M Asara

0 references

Gregory Stephanopoulos

35

Gregory Stephanopoulos

0 references

Francesco G Salituro

36

Francesco G Salituro

0 references

Shengfang Jin

37

Shengfang Jin

0 references

Lenny Dang

38

Lenny Dang

0 references

author name string

Yimin Yu

2

0 references

Matthew B Boxer

5

0 references

Min Shen

9

0 references

Abhishek Jha

10

0 references

Hua Yang

11

0 references

Kevin D Courtney

15

0 references

Charles Kung

18

0 references

Martin J Walsh

22

0 references

William Leister

24

0 references

Zachary R Johnson

26

0 references

Shawn M Davidson

29

0 references

James Inglese

32

0 references

Marian H Harris

33

0 references

Hee-Won Park

MetaboAnalyst 2.0--a comprehensive server for metabolomic data analysis

40

0 references

publication date

October 2012

0 references

published in

Nature Chemical Biology

0 references

volume

8

0 references

page(s)

839-47

0 references

issue

10

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Identification of small molecule inhibitors of pyruvate kinase M2

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Understanding the Warburg effect: the metabolic requirements of cell proliferation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Pyruvate kinase M2 is a phosphotyrosine-binding protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

20 March 2017

The Protein Data Bank

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Features and development of Coot

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Regulation of cancer cell metabolism

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

A positive/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Targeting cancer metabolism: a therapeutic window opens

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Evidence for an alternative glycolytic pathway in rapidly proliferating cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Targeting metabolic transformation for cancer therapy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Molecular imaging in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

ATP citrate lyase inhibition can suppress tumor cell growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Dominant negative role of the glutamic acid residue conserved in the pyruvate kinase M(1) isozyme in the heterotropic allosteric effect involving fructose-1,6-bisphosphate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Regulation of pyruvate kinase M gene expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Rewiring of glycolysis in cancer cell metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1,6-bisphosphate

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3711671

Processing of X-ray diffraction data collected in oscillation mode

2 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22922757

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxygen conformance of cellular respiration in hepatocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22922757

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Conversion of non-allosteric pyruvate kinase isozyme into an allosteric enzyme by a single amino acid substitution

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22922757

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.1060

1 reference

Dimensions Publication ID

2160655

1041031209

0 references

2160655

1 reference

1 reference

1 reference