(Q27689400)

8

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author name string

Christopher F Butler

1

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Caroline Peet

2

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Kirsty J McLean

3

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Michael T Baynham

4

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Richard T Blankley

5

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Karl Fisher

6

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Stephen E J Rigby

7

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Michael W Voice

9

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Andrew W Munro

Epoxyeicosatrienoic acid pathway in human health and diseases

10

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language of work or name

English

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publication date

1 June 2014

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published in

Biochemical Journal

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volume

460

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issue

2

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page(s)

247-59

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cites work

1 reference

Clinical importance of the cytochromes P450

20 April 2017

1 reference

Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily

20 April 2017

1 reference

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

20 April 2017

1 reference

Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes

20 April 2017

1 reference

Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias

20 April 2017

1 reference

Unusual Spectroscopic and Ligand Binding Properties of the Cytochrome P450-Flavodoxin Fusion Enzyme XplA

20 April 2017

1 reference

Phasercrystallographic software

20 April 2017

1 reference

REFMAC5 for the refinement of macromolecular crystal structures

20 April 2017

1 reference

Coot: model-building tools for molecular graphics

20 April 2017

1 reference

Pivotal role of water in the mechanism of P450BM-3

20 April 2017

1 reference

The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid

20 April 2017

1 reference

The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase

20 April 2017

1 reference

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

20 April 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Engineering the substrate specificity of cytochrome P450 CYP102A2 by directed evolution: production of an efficient enzyme for bioconversion of fine chemicals.

20 April 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Engineering the third wave of biocatalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Unusual cytochrome p450 enzymes and reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Hydroxylation of non-substituted polycyclic aromatic hydrocarbons by cytochrome P450 BM3 engineered by directed evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

P450(BM3) (CYP102A1): connecting the dots.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Roles of key active-site residues in flavocytochrome P450 BM3

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Neutral thiol as a proximal ligand to ferrous heme iron: implications for heme proteins that lose cysteine thiolate ligation on reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets. New heme ligation states influence conformational equilibria in P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Domains of the catalytically self-sufficient cytochrome P-450 BM-3. Genetic construction, overexpression, purification and spectroscopic characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Degradation of lansoprazole and omeprazole in the aquatic environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Metabolites in Safety Testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

21 January 2018

What makes a P450 tick?

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Pharmacokinetics and pharmacodynamics of esomeprazole, the S-isomer of omeprazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Effect of pharmaceutical excipients on aqueous stability of rabeprazole sodium

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Proton pump inhibitors in pediatrics : mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Identification of Critical Residues in Novel Drug Metabolizing Mutants of Cytochrome P450 BM3 Using Random Mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030

Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140030