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Structural basis of inhibitor selectivity in MAP kinases
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scholarly article
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title
Structural basis of inhibitor selectivity in MAP kinases
(English)
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author name string
Z Wang
series ordinal
1
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B J Canagarajah
series ordinal
2
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J C Boehm
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3
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S Kassisà
series ordinal
4
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M H Cobb
series ordinal
5
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P R Young
series ordinal
6
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S Abdel-Meguid
series ordinal
7
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J L Adams
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8
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E J Goldsmith
series ordinal
9
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publication date
15 September 1998
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published in
Structure
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volume
6
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page(s)
1117-28
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issue
9
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cites work
MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network
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How MAP kinases are regulated
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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
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The MAPK signaling cascade
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The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
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Parallel signal processing among mammalian MAPKs
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7 January 2021
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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
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Hyperexpression of mitogen-activated protein kinase in human breast cancer
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The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation
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An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
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ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
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The stress-activated protein kinase subfamily of c-Jun kinases
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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
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7 January 2021
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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
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A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
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Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.
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The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.
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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
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Sounding the alarm: protein kinase cascades activated by stress and inflammation
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Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors
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reference URL
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7 January 2021
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Inhibitors of serine/threonine kinases
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https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
1 reference
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https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
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https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
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reference URL
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7 January 2021
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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution
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7 January 2021
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The structure of mitogen-activated protein kinase p38 at 2.1-A resolution
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https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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Crystal structure of p38 mitogen-activated protein kinase
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https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
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https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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Protein kinases
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7 January 2021
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The effect of quercetin on the phosphorylatio activity of the Rous sarcoma virus transforming gene product in vitro and in vivo
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7 January 2021
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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase
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Crystal structure of cyclin-dependent kinase 2
1 reference
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Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine
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Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors
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Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases
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Hydrogen bonding in globular proteins
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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine
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7 January 2021
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Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors
1 reference
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7 January 2021
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SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
1 reference
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7 January 2021
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Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket.
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7 January 2021
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7 January 2021
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7 January 2021
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7 January 2021
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1 reference
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https://api.crossref.org/works/10.1016%2FS0969-2126%2898%2900113-0
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7 January 2021
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PROCHECK: a program to check the stereochemical quality of protein structures
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7 January 2021
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Identifiers
DOI
10.1016/S0969-2126(98)00113-0
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4503841
OpenCitations bibliographic resource ID
4503841
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4503841
PubMed ID
9753691
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4503841
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