(Q27851574)

English

UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy

scientific article

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scholarly article

2 references

13 November 2016

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

UGT1A and TYMS genetic variants predict toxicity and response of colorectal cancer patients treated with first-line irinotecan and fluorouracil combination therapy (English)

2 references

13 November 2016

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

0 references

colorectal cancer

1 reference

based on heuristic

inferred from title

0 references

colorectal carcinoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Eva Martínez-Balibrea

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Anna Martínez-Cardús

4

1 reference

Europe PubMed Central

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7 February 2020

15

1 reference

Europe PubMed Central

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7 February 2020

author name string

E Martinez-Balibrea

1

1 reference

Europe PubMed Central

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7 February 2020

A Abad

2

1 reference

Europe PubMed Central

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7 February 2020

A Ginés

5

1 reference

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7 February 2020

M Valladares

6

1 reference

Europe PubMed Central

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7 February 2020

M Navarro

7

1 reference

Europe PubMed Central

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7 February 2020

E Aranda

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

E Marcuello

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

M Benavides

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

B Massutí

11

1 reference

Europe PubMed Central

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7 February 2020

A Carrato

12

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

L Layos

13

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

J L Manzano

14

1 reference

Europe PubMed Central

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7 February 2020

language of work or name

0 references

publication date

13 July 2010

1 reference

Europe PubMed Central

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7 February 2020

British Journal of Cancer

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

103

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

581-589

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

20 March 2017

UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

20 March 2017

Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

20 March 2017

Thymidylate synthase pharmacogenetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

20 March 2017

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

20 March 2017

A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

20 March 2017

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

1 reference

https://api.crossref.org/works/10.1038/SJ.BJC.6605776

22 April 2017

Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Innovations in chemotherapy for metastatic colorectal cancer: an update of recent clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

UGT1A1*28 polymorphism predicts irinotecan-induced severe toxicities without affecting treatment outcome and survival in patients with metastatic colorectal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

29 September 2017

Randomized study of weekly irinotecan plus high-dose 5-fluorouracil (FUIRI) versus biweekly irinotecan plus 5-fluorouracil/leucovorin (FOLFIRI) as first-line chemotherapy for patients with metastatic colorectal cancer: a Spanish Cooperative Group fo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Association of molecular markers with toxicity outcomes in a randomized trial of chemotherapy for advanced colorectal cancer: the FOCUS trial

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Pharmacogenetic approach for capecitabine or 5-fluorouracil selection to be combined with oxaliplatin as first-line chemotherapy in advanced colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Relevance of different UGT1A1 polymorphisms in irinotecan-induced toxicity: a molecular and clinical study of 75 patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

Camptothecin analogues: studies from the Johns Hopkins Oncology Center.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

SNPStats: a web tool for the analysis of association studies.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

UGT1A1 Polymorphism Can Predict Hematologic Toxicity in Patients Treated with Irinotecan

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605776

21 January 2018

UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

27 November 2018

Association of thymidylate synthase gene polymorphism with its mRNA and protein expression and with prognosis in gastric cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

27 November 2018

Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939780

27 November 2018

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters

1 reference

https://pubmed.ncbi.nlm.nih.gov/20628391

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6605776

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Dimensions Publication ID

0 references

2 references

13 November 2016

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

2 references

13 November 2016

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20628391%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

ResearchGate publication ID

0 references

Springer Nature article ID

10.1038/sj.bjc.6605776

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