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Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity
scientific article
Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
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scholarly article
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PubMed
PubMed ID
24240700
retrieved
13 November 2016
title
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity
(English)
1 reference
stated in
PubMed
PubMed ID
24240700
retrieved
13 November 2016
author
Rachael Natrajan
series ordinal
15
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Alan Ashworth
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17
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Christopher J Lord
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Christopher J Lord
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16
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James Campbell
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7
object named as
James Campbell
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Rachel Brough
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6
object named as
Rachel Brough
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Ilirjana Bajrami
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1
object named as
Ilirjana Bajrami
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Jessica R Frankum
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2
object named as
Jessica R Frankum
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Asha Konde
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3
object named as
Asha Konde
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Rowan E Miller
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4
object named as
Rowan E Miller
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Farah L Rehman
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5
object named as
Farah L Rehman
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Rumana Rafiq
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9
object named as
Rumana Rafiq
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Iwanka Kozarewa
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12
object named as
Iwanka Kozarewa
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Ioannis Assiotis
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13
object named as
Ioannis Assiotis
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Kerry Fenwick
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14
object named as
Kerry Fenwick
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author name string
David Sims
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8
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Sean Hooper
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10
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Lina Chen
series ordinal
11
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language of work or name
English
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publication date
1 January 2014
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published in
Cancer Research
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volume
74
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page(s)
287-97
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issue
1
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cites work
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
Predisposition to cancer caused by genetic and functional defects of mammalian Atad5
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
Integrated genomic analyses of ovarian carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
Germline mutations in RAD51D confer susceptibility to ovarian cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
Resistance to therapy caused by intragenic deletion in BRCA2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
20 March 2017
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
7 April 2017
STRING v9.1: protein-protein interaction networks, with increased coverage and integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
7 April 2017
Predicting enhanced cell killing through PARP inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Absolute quantification of somatic DNA alterations in human cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
The Smc complexes in DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
The DNA damage response and cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Rapid creation and quantitative monitoring of high coverage shRNA libraries
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
29 September 2017
Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
27 November 2018
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4886090
retrieved
27 November 2018
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24240700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24240700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/0008-5472.CAN-13-2541
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3584971
OpenCitations bibliographic resource ID
3584971
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3584971
PMCID
4886090
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3584971
PubMed ID
24240700
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3584971
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