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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
scientific article
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition
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scholarly article
1 reference
stated in
PubMed
PubMed ID
24651015
retrieved
13 November 2016
title
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
(English)
1 reference
stated in
PubMed
PubMed ID
24651015
retrieved
13 November 2016
main subject
cell biology
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medulloblastoma
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author
Benedikt Brors
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Christof von Kalle
series ordinal
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Roland Eils
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Andreas von Deimling
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Andreas von Deimling
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Christel Herold-Mende
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object named as
Christel Herold-Mende
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Jüri Reimand
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object named as
Jüri Reimand
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Huriye Seker-Cin
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Huriye Seker-Cin
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Peter van Sluis
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34
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Peter van Sluis
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Andreas Unterberg
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Andreas Unterberg
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Cynthia Cowdrey
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56
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Cynthia Cowdrey
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Ulrich Schüller
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Ulrich Schüller
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Martin Hasselblatt
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Martin Hasselblatt
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Nada Jabado
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Nada Jabado
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Tobias Rausch
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Volker Hovestadt
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Volker Hovestadt
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Dominik Sturm
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Dominik Sturm
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Till Milde
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Till Milde
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Trevor J Pugh
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Marc Remke
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Marc Remke
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Rogier Versteeg
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Rogier Versteeg
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Jan Koster
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Jan Koster
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Rosario M. Piro
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Rosario M Piro
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Martin McCabe
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Martin G McCabe
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Mark W. Kieran
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Gary D. Bader
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Gary D Bader
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Stefan M. Pfister
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Olivier Delattre
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Franck Bourdeaut
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Franck Bourdeaut
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Jörg Felsberg
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Peter Lichter
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Peter Lichter
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Marcel Kool
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Paul A Northcott
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Paul A Northcott
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Andrey Korshunov
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Rameen Beroukhim
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Rameen Beroukhim
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David T. W. Jones
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François Doz
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Francois Doz
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Robert J Wechsler-Reya
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Robert J Wechsler-Reya
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Scott L Pomeroy
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Scott L Pomeroy
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Yoon-Jae Cho
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Yoon-Jae Cho
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David J. H. Shih
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David Shih
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Andreas E Kulozik
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Andreas E Kulozik
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Michael D. Taylor
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Michael D Taylor
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Jan Korbel
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Jan O Korbel
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John R Crawford
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John R Crawford
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Natalie Jäger
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Natalie Jäger
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Marina Ryzhova
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Marina Ryzhova
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Elke Pfaff
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Elke Pfaff
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Laura Sieber
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Laura Sieber
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Sonja Hutter
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Sonja Hutter
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Cynthia C Bartholomae
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Cynthia C Bartholomae
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Chris Lawerenz
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Chris Lawerenz
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Richard Volckmann
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Richard Volckmann
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Olaf Witt
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Olaf Witt
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Wolfram Scheurlen
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Wolfram Scheurlen
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Marc Zapatka
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Marc Zapatka
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Sebastian Stark
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Sebastian Stark
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Linda Linke
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27
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Linda Linke
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Pascal Johann
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Pascal Johann
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Arie Perry
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Arie Perry
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Silvia Hofer
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Silvia Hofer
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Christin Schmidt
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Christin Schmidt
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Guillaume Bergthold
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Guillaume Bergthold
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Gelareh Zadeh
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author name string
L Adriana Esparza
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8
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Shirley L Markant
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9
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Sebastian Bender
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20
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Andrea Wittmann
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Hendrik Witt
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Ursula D Weber
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Rainer König
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Sabine Schmidt
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38
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Stephan Wolf
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Gerald A Grant
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Sydney Croul
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V Peter Collins
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0 references
publication date
17 March 2014
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published in
Cancer Cell
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volume
25
0 references
page(s)
393-405
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issue
3
0 references
cites work
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
Dissecting the genomic complexity underlying medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
The crosstalk of mTOR/S6K1 and Hedgehog pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
Molecular subgroups of medulloblastoma: the current consensus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
The 2007 WHO classification of tumours of the central nervous system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
Subgroup-specific structural variation across 1,000 medulloblastoma genomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
The genetic landscape of the childhood cancer medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
20 March 2017
The origin and evolution of mutations in acute myeloid leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
7 April 2017
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
24 May 2017
TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Medulloblastomics: the end of the beginning
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Medulloblastoma with excessive nodularity: radiographic features and pathologic correlate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Novel mutations target distinct subgroups of medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Hedgehog pathway as a drug target: Smoothened inhibitors in development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
The Hedgehog's tale: developing strategies for targeting cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Clinical experience with Hedgehog pathway inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Medulloblastoma comprises four distinct molecular variants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Adult neuroectodermal tumors of posterior fossa (medulloblastoma) and of supratentorial sites (stPNET).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
Common strategy for adult and pediatric medulloblastoma: a multicenter series of 253 adults
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
29 September 2017
PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
2 June 2018
High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
2 June 2018
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
2 June 2018
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
2 June 2018
Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
27 November 2018
Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
27 November 2018
Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
27 November 2018
Not lost in space: trafficking in the hedgehog signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
27 November 2018
Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
27 November 2018
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
27 November 2018
Loss of suppressor-of-fused function promotes tumorigenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
27 November 2018
Survival of adults treated for medulloblastoma using paediatric protocols.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4493053
retrieved
27 November 2018
Identifiers
DOI
10.1016/J.CCR.2014.02.004
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
324517
Fatcat ID
release_qc25q7h6kvfk5ko63vw4g7qley
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/qc25q7h6kvfk5ko63vw4g7qley
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
324517
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
324517
PMCID
4493053
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
324517
PubMed ID
24651015
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
324517
ResearchGate publication ID
262046701
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