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TOR, a central controller of cell growth
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
11057898
retrieved
1 December 2016
review article
1 reference
stated in
Europe PubMed Central
title
TOR, a central controller of cell growth
(English)
1 reference
stated in
PubMed
PubMed ID
11057898
retrieved
1 December 2016
author name string
T Schmelzle
series ordinal
1
0 references
M N Hall
series ordinal
2
0 references
language of work or name
English
0 references
publication date
13 October 2000
0 references
published in
Cell
1 reference
stated in
PubMed
PubMed ID
11057898
retrieved
1 December 2016
volume
103
0 references
page(s)
253-62
0 references
issue
2
0 references
cites work
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
1 reference
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Crossref
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7 January 2021
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HEAT repeats in the Huntington's disease protein
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
TOR controls translation initiation and early G1 progression in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
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The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
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The 14-3-3 proteins positively regulate rapamycin-sensitive signaling
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Crossref
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7 January 2021
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Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes
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7 January 2021
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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.
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Crossref
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7 January 2021
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FAT: a novel domain in PIK-related kinases
1 reference
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Crossref
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Stat3 as an oncogene
1 reference
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Crossref
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A mammalian protein targeted by G1-arresting rapamycin-receptor complex
1 reference
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Crossref
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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
1 reference
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Crossref
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7 January 2021
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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
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Crossref
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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
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The TOR signaling cascade regulates gene expression in response to nutrients
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
1 reference
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Crossref
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7 January 2021
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Alpha 4 associates with protein phosphatases 2A, 4, and 6
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Size control in animal development
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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inferred from DOI database lookup
Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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From small flies come big discoveries about size control.
1 reference
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Crossref
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7 January 2021
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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1 reference
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Crossref
reference URL
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7 January 2021
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Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
1 reference
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Crossref
reference URL
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Regulation of eIF-4E BP1 phosphorylation by mTOR.
1 reference
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Crossref
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7 January 2021
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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
1 reference
stated in
Crossref
reference URL
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Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
1 reference
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Crossref
reference URL
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7 January 2021
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Macromolecule Synthesis in Temperature-sensitive Mutants of Yeast
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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inferred from DOI database lookup
Studies on the mechanism of resistance to rapamycin in human cancer cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
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inferred from DOI database lookup
Drosophila myc regulates cellular growth during development.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Direct control of the Forkhead transcription factor AFX by protein kinase B
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Perspectives: cell biology. All creatures great and small
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of transcription of rRNA genes by rapamycin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A protein conjugation system essential for autophagy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drosophila S6 kinase: a regulator of cell size.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Connections between growth and the cell cycle
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple pathways control protein kinase C phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras1 promotes cellular growth in the Drosophila wing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The modular phosphorylation and activation of p70s6k.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation and activation of p70s6k by PDK1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of c-myc in cellular growth control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TOR2 is required for organization of the actin cytoskeleton in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mRNA 5' cap-binding protein eIF4E and control of cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TOR signalling and control of cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The PI3K-PDK1 connection: more than just a road to PKB
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The economics of ribosome biosynthesis in yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The genetic control of organ growth: insights from Drosophila.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of RNA polymerases I and III by the retinoblastoma protein: a mechanism for growth control?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2900117-3
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0092-8674(00)00117-3
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
648285
OpenCitations bibliographic resource ID
648285
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
648285
PubMed ID
11057898
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
648285
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