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Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function
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scholarly article
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PubMed
PubMed ID
27068472
retrieved
1 December 2016
title
Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function
(English)
1 reference
stated in
PubMed
PubMed ID
27068472
retrieved
1 December 2016
main subject
Hsp90 family chaperone HSP82 YPL240C
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GOA release 2020-03-11
author name string
Parul Mishra
series ordinal
1
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Julia M Flynn
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2
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Tyler N Starr
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3
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Daniel N A Bolon
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4
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language of work or name
English
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publication date
19 April 2016
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published in
Cell Reports
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PubMed
PubMed ID
27068472
retrieved
1 December 2016
volume
15
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page(s)
588-98
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issue
3
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cites work
Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles
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Hsp90-Tau complex reveals molecular basis for specificity in chaperone action
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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition
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20 March 2017
Experimental illumination of a fitness landscape
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20 March 2017
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
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20 March 2017
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
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20 March 2017
Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions
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Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1
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20 March 2017
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains
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20 March 2017
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
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PubMed Central
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20 March 2017
In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
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20 March 2017
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
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20 March 2017
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation
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20 March 2017
Two genes required for cell fusion during yeast conjugation: evidence for a pheromone-induced surface protein
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20 March 2017
hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures
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PubMed Central
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20 March 2017
Stressing the development of small molecules targeting HSP90
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PubMed Central
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20 March 2017
Slightly Deleterious Mutant Substitutions in Evolution
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20 March 2017
A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans
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20 March 2017
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
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7 April 2017
Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.
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29 September 2017
Functions of the Hsp90-binding FKBP immunophilins.
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29 September 2017
Viewing protein fitness landscapes through a next-gen lens.
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29 September 2017
Deep mutational scanning: a new style of protein science
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29 September 2017
Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
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29 September 2017
Shifting fitness landscapes in response to altered environments.
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PubMed Central
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29 September 2017
Latent effects of Hsp90 mutants revealed at reduced expression levels
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PubMed Central
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29 September 2017
The therapeutic target Hsp90 and cancer hallmarks
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29 September 2017
Fitness analyses of all possible point mutations for regions of genes in yeast
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PubMed Central
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29 September 2017
Solubility-promoting function of Hsp90 contributes to client maturation and robust cell growth
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PubMed Central
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29 September 2017
Hsp90 and client protein maturation
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PubMed Central
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29 September 2017
Enforced N-domain proximity stimulates Hsp90 ATPase activity and is compatible with function in vivo
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PubMed Central
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29 September 2017
Modular control of cross-oligomerization: analysis of superstabilized Hsp90 homodimers in vivo
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PubMed Central
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29 September 2017
Population genomics of the wild yeast Saccharomyces paradoxus: Quantifying the life cycle
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PubMed Central
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29 September 2017
Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
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PubMed Central
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29 September 2017
The middle domain of Hsp90 acts as a discriminator between different types of client proteins
1 reference
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PubMed Central
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29 September 2017
Structure of an Hsp90-Cdc37-Cdk4 complex.
1 reference
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29 September 2017
The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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29 September 2017
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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29 September 2017
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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29 September 2017
Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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29 September 2017
Hsp90 is required for pheromone signaling in yeast
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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29 September 2017
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
1 reference
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PubMed Central
reference URL
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29 September 2017
Heat-shock protein hsp90 governs the activity of pp60v-src kinase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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29 September 2017
Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells
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PubMed Central
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2 June 2018
Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle
1 reference
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PubMed Central
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2 June 2018
Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle
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PubMed Central
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2 June 2018
Reduced levels of hsp90 compromise steroid receptor action in vivo
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PubMed Central
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2 June 2018
Proline for alanine substitutions in the C-peptide helix of ribonuclease A.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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2 June 2018
Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop.
1 reference
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PubMed Central
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27 November 2018
Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery.
1 reference
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PubMed Central
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27 November 2018
Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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27 November 2018
Evolutionary replacement of components in a salamander pheromone signaling complex: more evidence for phenotypic-molecular decoupling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
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27 November 2018
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
retrieved
27 November 2018
Coordinated ATP hydrolysis by the Hsp90 dimer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4838542
retrieved
27 November 2018
Coupled assay of Na+,K+-ATPase activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27068472
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27068472
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27068472
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELREP.2016.03.046
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PMCID
4838542
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PubMed ID
27068472
1 reference
stated in
PubMed
PubMed ID
27068472
retrieved
1 December 2016
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