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Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells
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scholarly article
1 reference
stated in
PubMed
PubMed ID
11101534
retrieved
1 December 2016
title
Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells
(English)
1 reference
stated in
PubMed
PubMed ID
11101534
retrieved
1 December 2016
main subject
Serine/threonine-protein kinase GCN2 YDR283C
1 reference
stated in
GOA release 2020-03-11
Gcn1p YGL195W
1 reference
stated in
GOA release 2020-03-11
Putative AAA family ATPase GCN20 YFR009W
1 reference
stated in
GOA release 2020-03-11
author name string
E Sattlegger
series ordinal
1
0 references
A G Hinnebusch
series ordinal
2
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language of work or name
English
0 references
publication date
1 December 2000
0 references
published in
The EMBO Journal
1 reference
stated in
PubMed
PubMed ID
11101534
retrieved
1 December 2016
volume
19
0 references
page(s)
6622-33
0 references
issue
23
0 references
cites work
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain
1 reference
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PubMed Central
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Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation
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A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha
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Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase
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Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
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Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase
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eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.
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20 March 2017
Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control
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PubMed Central
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20 March 2017
Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2
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PubMed Central
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20 March 2017
GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.
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PubMed Central
reference URL
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20 March 2017
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids
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PubMed Central
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GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells
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PubMed Central
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Misreading of the ribosomal suppressor SUP46 due to an altered 40 S subunit in yeast
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20 March 2017
Positive regulation in the general amino acid control of Saccharomyces cerevisiae
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PubMed Central
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20 March 2017
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
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20 March 2017
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
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20 March 2017
Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression
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20 March 2017
GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiae
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PubMed Central
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20 March 2017
Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae
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PubMed Central
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20 March 2017
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
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PubMed Central
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20 March 2017
Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 gene
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PubMed Central
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7 April 2017
Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeast
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7 April 2017
Sterile host yeasts (SHY): A eukaryotic system of biological containment for recombinant DNA experiments
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7 April 2017
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29 September 2017
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29 September 2017
Eukaryotic initiation factor eIF2.
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PubMed Central
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29 September 2017
cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control
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PubMed Central
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29 September 2017
Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2
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29 September 2017
Cloning and characterization of a cDNA encoding a protein synthesis initiation factor-2alpha (eIF-2alpha) kinase from Drosophila melanogaster. Homology To yeast GCN2 protein kinase
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PubMed Central
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29 September 2017
Collection of small subunit (16S- and 16S-like) ribosomal RNA structures: 1994
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PubMed Central
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29 September 2017
Mutations in elongation factor EF-1 alpha affect the frequency of frameshifting and amino acid misincorporation in Saccharomyces cerevisiae
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PubMed Central
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29 September 2017
Uncharged tRNA, protein synthesis, and the bacterial stringent response
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29 September 2017
Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics
1 reference
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PubMed Central
reference URL
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29 September 2017
Phenotypic suppression and misreading in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
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29 September 2017
Codon-specific interaction of uncharged transfer-RNA with eukaryotic ribosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305848
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29 September 2017
Ribosomes and translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305848
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2 June 2018
GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305848
retrieved
27 November 2018
Misreading of RNA codewords induced by aminoglycoside antibiotics
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11101534
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/EMBOJ/19.23.6622
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3089715
OpenCitations bibliographic resource ID
3089715
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3089715
PMCID
305848
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3089715
PubMed ID
11101534
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3089715
ResearchGate publication ID
12225557
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