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Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

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24 March 2020

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Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans (English)

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24 March 2020

Franck A Atienzar

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24 March 2020

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Philip Hewitt

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24 March 2020

Gilles Labbe

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Frederic Moulin

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Francois Pognan

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Laura Suter-Dick

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Okechukwu Ukairo

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Yvonne Will

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Eric A Blomme

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Adrian B Roth

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Richard J Weaver

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Donna M Dambach

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BioMed Research International

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1 January 2016

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Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury

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The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

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Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

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Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells

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Minimum Information About a Microarray Experiment (MIAME)--successes, failures, challenges

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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans

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Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

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Biokinetics in repeated-dosing in vitro drug toxicity studies.

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A comprehensive study of the association between drug hepatotoxicity and daily dose, liver metabolism, and lipophilicity using 975 oral medications.

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Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging

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29 September 2017

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays

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29 September 2017

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29 September 2017

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes

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29 September 2017

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

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29 September 2017

Development of novel tools for the in vitro investigation of drug-induced liver injury.

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29 September 2017

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents.

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29 September 2017

Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project

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Multiparametric assay using HepaRG cells for predicting drug-induced liver injury

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29 September 2017

Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists

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29 September 2017

Dimethyl sulfoxide damages mitochondrial integrity and membrane potential in cultured astrocytes

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Comprehensive in vitro Proarrhythmia Assay, a novel in vitro/in silico paradigm to detect ventricular proarrhythmic liability: a visionary 21st century initiative

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Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines

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Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data

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MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data

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High-content analysis/screening for predictive toxicology: application to hepatotoxicity and genotoxicity.

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Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

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29 September 2017

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29 September 2017

Risk factors for idiosyncratic drug-induced liver injury

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29 September 2017

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29 September 2017

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29 September 2017

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

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29 September 2017

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29 September 2017

Epidemiology of idiosyncratic drug-induced liver injury

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29 September 2017

Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport.

1 reference

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29 September 2017

Current concepts of mechanisms in drug-induced hepatotoxicity

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29 September 2017

Cell based approaches for evaluation of drug-induced liver injury.

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29 September 2017

Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

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29 September 2017

Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: a preliminary study using a multiplexing approach

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29 September 2017

The future of drug safety testing: expanding the view and narrowing the focus

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29 September 2017

Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line

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29 September 2017

The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells

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29 September 2017

Making a new technology work: the standardization and regulation of microarrays.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Reproducible and reliable microarray results through quality control: good laboratory proficiency and appropriate data analysis practices are essential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

The significance of mitochondrial toxicity testing in drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Idiosyncratic toxicity: a convergence of risk factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Idiosyncratic drug hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Cytotoxic effects of 100 reference compounds on Hep G2 and HeLa cells and of 60 compounds on ECC-1 and CHO cells. I mechanistic assays on ROS, glutathione depletion and calcein uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

New technologies and screening strategies for hepatotoxicity: use of in vitro models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Causality assessment in drug-induced hepatotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Drug-induced hepatotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Cooperation of liver cells in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Human cancer cell lines: fact and fantasy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Concordance of the toxicity of pharmaceuticals in humans and in animals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Influence of serum protein binding on the uptake and retention of idarubicin by sensitive and multidrug resistant human leukemic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

The predictivity of the toxicity of pharmaceuticals in humans from animal data--an interim assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Mitochondrial injury. Lessons from the fialuridine trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

In vitro methods in regulatory toxicology: the crucial significance of validation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

29 September 2017

Minimizing DILI risk in drug discovery - A screening tool for drug candidates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

2 June 2018

Long-term stability of primary rat hepatocytes in micropatterned cocultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

2 June 2018

Comparison of a genomic and a multiplex cell imaging approach for the detection of phospholipidosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

2 June 2018

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Phenotypic characterization of idiosyncratic drug-induced liver injury: the influence of age and sex.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Cellular imaging predictions of clinical drug-induced liver injury

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Modeling mass transfer in hepatocyte spheroids via cell viability, spheroid size, and hepatocellular functions.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

An oxygen-permeable spheroid culture system for the prevention of central hypoxia and necrosis of spheroids.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Human precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Developing structure-activity relationships for the prediction of hepatotoxicity.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Drugs associated with hepatotoxicity and their reporting frequency of liver adverse events in VigiBase: unified list based on international collaborative work.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Developing a QSAR model for hepatotoxicity screening of the active compounds in traditional Chinese medicines.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

The cost-effectiveness of drug regulation: the example of thorough QT/QTc studies.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

The impact of drug-related QT prolongation on FDA regulatory decisions

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

FDA-approved drug labeling for the study of drug-induced liver injury

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F9737920

21 January 2018

Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5027328

27 November 2018

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An integrated, multidisciplinary approach for drug safety assessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Drug-induced liver injury; fourteenth updated edition of the bibliographic database of liver injuries and related drugs]

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Searching for array standards in Rockville

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sudden Death in Noncoronary Heart Disease Is Associated With Delayed Paced Ventricular Activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The danger hypothesis applied to idiosyncratic drug reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolving concepts in liver tissue modeling and implications for in vitro toxicology

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting safety toleration of pharmaceutical chemical leads: cytotoxicity correlations to exploratory toxicity studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of liver specific toxicities in rat hepatocytes by high content imaging during 2-week multiple treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: a follow-up to an ECVAM workshop

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity testing in the 21st century: a view from the pharmaceutical industry

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of a standardised and validated long-term human hepatocyte culture system for repetitive analyses of drugs: repeated administrations of acetaminophen reduces albumin and urea secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-Induced Liver Injury and Individual Cell Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans. Part A: use of FDA post-market reports to create a database of hepatobiliary and urinary tract toxicities

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-induced liver injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-induced liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant properties of dimethyl sulfoxide and its viability as a solvent in the evaluation of neuroprotective antioxidants

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-induced Liver Injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689095

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2016/9737920

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27689095%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27689095%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27689095%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

Sitelinks

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