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Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion
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title
Feeding an army: The metabolism of T cells in activation, anergy, and exhaustion
(English)
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author name string
Greg M. Delgoffe
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1
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Jonathan D. Powell
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2
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English
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publication date
December 2015
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published in
Molecular Immunology
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volume
68
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issue
2 Pt C
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page(s)
492-6
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Posttranscriptional control of T cell effector function by aerobic glycolysis
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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
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CTLA-4 can function as a negative regulator of T cell activation
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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
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T cell exhaustion
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PubMed Central
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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
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Environmental and metabolic sensors that control T cell biology
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29 September 2017
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
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PubMed Central
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29 September 2017
mTOR signaling and transcriptional regulation in T lymphocytes
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PubMed Central
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The transcription factor NFAT promotes exhaustion of activated CD8⁺ T cells.
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29 September 2017
Fatty acid metabolism in the regulation of T cell function
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PubMed Central
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mTOR signaling in cellular and organismal energetics
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29 September 2017
The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection
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PubMed Central
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29 September 2017
Molecular regulation of effector and memory T cell differentiation
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PubMed Central
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Mitochondrial and cellular mechanisms for managing lipid excess
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PubMed Central
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29 September 2017
Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.
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PubMed Central
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29 September 2017
Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection
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29 September 2017
Cellular metabolism modulation in T lymphocyte immunity
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29 September 2017
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
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PubMed Central
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The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism
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29 September 2017
Anergic T cells are metabolically anergic
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PubMed Central
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29 September 2017
Redefining chronic viral infection
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29 September 2017
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
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PubMed Central
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29 September 2017
PD-1 signaling in primary T cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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29 September 2017
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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29 September 2017
Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3.
1 reference
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PubMed Central
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29 September 2017
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
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PubMed Central
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29 September 2017
Sirolimus (rapamycin): from the soil of Easter Island to a bright future
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29 September 2017
Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
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PubMed Central
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29 September 2017
Cancer's molecular sweet tooth and the Warburg effect.
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29 September 2017
Egr-2 and Egr-3 are negative regulators of T cell activation.
1 reference
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PubMed Central
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29 September 2017
Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling
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29 September 2017
T cell anergy
1 reference
stated in
PubMed Central
reference URL
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29 September 2017
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
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29 September 2017
The CD28 signaling pathway regulates glucose metabolism
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29 September 2017
Transcriptional mechanisms underlying lymphocyte tolerance.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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29 September 2017
Protein kinase B (Akt) regulation and function in T lymphocytes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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29 September 2017
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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29 September 2017
The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
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PubMed Central
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Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice
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FK 506: an immunosuppressant for the 1990s?
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29 September 2017
FK-506 and cyclosporin A: immunosuppressive mechanism of action and beyond
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29 September 2017
Immune exhaustion: driving virus-specific CD8+ T cells to death
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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2 June 2018
Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming to promote memory formation and metabolic readiness.
1 reference
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27 November 2018
Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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27 November 2018
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4837657
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27 November 2018
The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells
1 reference
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PubMed Central
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27 November 2018
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
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27 November 2018
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation
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27 November 2018
γc cytokines provide multiple homeostatic signals to naive CD4+ T cells
1 reference
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PubMed
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12 December 2020
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Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy
1 reference
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https://pubmed.ncbi.nlm.nih.gov/26256793
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12 December 2020
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Identifiers
DOI
10.1016/J.MOLIMM.2015.07.026
0 references
PMC publication ID
4837657
1 reference
stated in
PubMed
PubMed publication ID
26256793
1 reference
stated in
PubMed
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