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PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
title
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma
(English)
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
main subject
glioblastoma
1 reference
based on heuristic
inferred from title
author name string
J. R. Molina
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
N. K. Agarwal
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
F. C. Morales
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
Y. Hayashi
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
K. D. Aldape
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
G. Cote
series ordinal
6
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
M.-M. Georgescu
series ordinal
7
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
language of work or name
English
0 references
publication date
8 March 2012
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
published in
Oncogene
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
volume
31
1 reference
stated in
PubMed
PubMed ID
21804599
retrieved
4 January 2017
page(s)
1264–1274
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PubMed
PubMed ID
21804599
retrieved
4 January 2017
issue
10
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PubMed
PubMed ID
21804599
retrieved
4 January 2017
describes a project that uses
ImageJ
1 reference
stated in
Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3208076/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
cites work
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Loss of PTEN binding adapter protein NHERF1 from plasma membrane in glioblastoma contributes to PTEN inactivation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
PHLiPPing the switch on Akt and protein kinase C signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
The PI3K pathway as drug target in human cancer
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
NCBI GEO: mining tens of millions of expression profiles--database and tools update
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
20 March 2017
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
NHERF1/EBP50 is a new marker in colorectal cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
Invasive glioblastoma cells acquire stemness and increased Akt activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
PI3K/Akt: getting it right matters
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
Roles of NHERF1/EBP50 in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
N-terminal PDZ domain is required for NHERF dimerization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3208076
retrieved
29 September 2017
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FONC.2011.324
retrieved
21 January 2018
Expression and clinicopathological significance of oestrogen-responsive ezrin-radixin-moesin-binding phosphoprotein 50 in breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FONC.2011.324
retrieved
31 March 2020
Identifiers
DOI
10.1038/ONC.2011.324
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2433513
Dimensions Publication ID
1010830139
0 references
OpenCitations bibliographic resource ID
2433513
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2433513
PMCID
3208076
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2433513
PubMed ID
21804599
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2433513
ResearchGate publication ID
51535855
0 references
Springer Nature article ID
10.1038/onc.2011.324
0 references
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