(Q28117252)

English

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE

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scholarly article

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PubMed publication ID

4 January 2017

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE (English)

1 reference

PubMed publication ID

4 January 2017

cytochrome P450 family 21 subfamily A member 2

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

8

0 references

author name string

Pradeep S. Pallan

1

1 reference

PubMed publication ID

4 January 2017

Chunxue Wang

2

1 reference

PubMed publication ID

4 January 2017

Li Lei

3

1 reference

PubMed publication ID

4 January 2017

Francis K. Yoshimoto

4

1 reference

PubMed publication ID

4 January 2017

Richard J. Auchus

5

1 reference

PubMed publication ID

4 January 2017

Michael R. Waterman

6

1 reference

PubMed publication ID

4 January 2017

F. Peter Guengerich

7

1 reference

PubMed publication ID

4 January 2017

language of work or name

0 references

publication date

22 May 2015

1 reference

PubMed publication ID

4 January 2017

Journal of Biological Chemistry

1 reference

PubMed publication ID

4 January 2017

290

1 reference

PubMed publication ID

4 January 2017

21

1 reference

PubMed publication ID

4 January 2017

13128–13143

1 reference

PubMed publication ID

4 January 2017

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

Structural diversity of eukaryotic membrane cytochrome p450s

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

Versatility of Y-family Sulfolobus solfataricus DNA Polymerase Dpo4 in Translesion Synthesis Past Bulky N2-Alkylguanine Adducts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

Molecular replacement with MOLREP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

UCSF Chimera--a visualization system for exploratory research and analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

REFMAC5 for the refinement of macromolecular crystal structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

The CCP4 suite: programs for protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

Cytochrome P450 2D Catalyze Steroid 21-Hydroxylation in the Brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 March 2017

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

7 April 2017

Multiparametric scaling of diffraction intensities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

7 April 2017

Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

7 April 2017

Structure-phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

Why human cytochrome P450c21 is a progesterone 21-hydroxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: the major autoantigen in autoimmune Addison's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

The new CCP4 Coordinate Library as a toolkit for the design of coordinate-related applications in protein crystallography.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

29 September 2017

Epoxidation activities of human cytochromes P450c17 and P450c21.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

2 June 2018

Steroid 21-hydroxylase deficiency: mutational spectrum in Denmark, three novel mutations, and in vitro expression analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

2 June 2018

Results of screening 1.9 million Texas newborns for 21-hydroxylase-deficient congenital adrenal hyperplasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505568

20 June 2018

Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

Purification and characterization of bovine steroid 21-hydroxylase (P450c21) efficiently expressed in Escherichia coli.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

The rate-determining step in P450 C21-catalyzing reactions in a membrane-reconstituted system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

Inhibition of CYP21A2 enzyme activity caused by novel missense mutations identified in Brazilian and Scandinavian patients

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

Phenotype-genotype correlations of 13 rare CYP21A2 mutations detected in 46 patients affected with 21-hydroxylase deficiency and in one carrier

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

Molecular characterization of 25 Chinese pedigrees with 21-hydroxylase deficiency.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

A Novel Missense Mutation, GLY424SER, in Brazilian Patients with 21-Hydroxylase Deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.646307

21 January 2018

Deuterium and tritium kinetic isotope effects on initial rates

1 reference

https://pubmed.ncbi.nlm.nih.gov/25855791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/25855791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/25855791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the steroid hydroxylation system in adrenal cortex microsomes. Purification and characterization of cytochrome P-450 specific for steroid C-21 hydroxylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25855791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of rabbit microsomal cytochrome P-450 isozyme, form 1, as a hepatic progesterone 21-hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25855791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of four CYP21 mutations from spanish patients with congenital adrenal hyperplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25855791

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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