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p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
title
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
(English)
1 reference
stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
main subject
Sestrin 2
1 reference
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GOA release 2020-03-11
Sestrin 1
1 reference
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GOA release 2020-03-11
negative regulation of TORC1 signaling
1 reference
stated in
GOA release 2020-03-11
Sestrin 2
1 reference
stated in
GOA release 2020-03-11
Tuberin
1 reference
stated in
GOA release 2020-03-11
TSC complex subunit 1
1 reference
stated in
GOA release 2020-03-11
genotoxicity
1 reference
based on heuristic
inferred from title
author
Michael Karin
series ordinal
2
object named as
Michael Karin
1 reference
stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
author name string
Andrei V. Budanov
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
language of work or name
English
0 references
publication date
8 August 2008
1 reference
stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
published in
Cell
1 reference
stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
volume
134
1 reference
stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
page(s)
451–460
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stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
issue
3
1 reference
stated in
PubMed
PubMed ID
18692468
retrieved
4 January 2017
cites work
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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
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mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
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TOR signaling in growth and metabolism
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20 March 2017
TSC2 mediates cellular energy response to control cell growth and survival
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PubMed Central
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20 March 2017
p53, the cellular gatekeeper for growth and division
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20 March 2017
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
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Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
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N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation
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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
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20 March 2017
p53 in health and disease
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PubMed Central
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mTOR and cancer: insights into a complex relationship
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29 September 2017
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
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29 September 2017
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Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways
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29 September 2017
PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse
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Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration
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29 September 2017
Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.
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29 September 2017
p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation
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29 September 2017
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29 September 2017
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29 September 2017
Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells.
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The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability.
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27 November 2018
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.
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27 November 2018
Zonation of cytochrome P450 isozyme expression and induction in rat liver
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18692468
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/18692468
retrieved
12 December 2020
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Identifiers
DOI
10.1016/J.CELL.2008.06.028
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
946476
OpenCitations bibliographic resource ID
946476
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
946476
PMCID
2758522
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
946476
PubMed ID
18692468
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
946476
ResearchGate publication ID
23161145
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