(Q28131826)

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

Europe PubMed Central

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7 January 2021

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7 January 2021

Genetic instability in colorectal cancers

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Loss of heterozygosity and base substitution at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines

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7 January 2021

Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer

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7 January 2021

Cytogenetic analysis of colorectal adenomas: karyotypic comparisons of synchronous tumors

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7 January 2021

Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells

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7 January 2021

A p53-dependent mouse spindle checkpoint

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7 January 2021

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

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7 January 2021

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

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7 January 2021

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7 January 2021

The genetics of cell cycle checkpoints

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7 January 2021

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7 January 2021

When checkpoints fail

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7 January 2021

Mutations of mitotic checkpoint genes in human cancers

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7 January 2021

Identification of a human mitotic checkpoint gene: hsMAD2

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7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

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7 January 2021

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

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Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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7 January 2021

Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

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7 January 2021

Abnormal centrosome amplification in the absence of p53.

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7 January 2021

Primary vs. secondary neoplasia-associated chromosomal abnormalities--balanced rearrangements vs. genomic imbalances?

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7 January 2021

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

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7 January 2021

Inactivation of p53 results in high rates of homologous recombination

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7 January 2021

T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues

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7 January 2021

DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations

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7 January 2021

Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis

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7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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7 January 2021

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

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7 January 2021

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment

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7 January 2021

Double-Strand Break Repair Deficiency and Radiation Sensitivity in BRCA2 Mutant Cancer Cells

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7 January 2021

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021