Open main menu
Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q28131826)
Watch
Edit
English
Genetic instabilities in human cancers
scientific article (publication date: 17 December 1998)
In more languages
edit
Statements
instance of
scholarly article
0 references
review article
1 reference
stated in
Europe PubMed Central
title
Genetic instabilities in human cancers
(English)
0 references
author
Bert Vogelstein
series ordinal
3
object named as
B Vogelstein
0 references
Kenneth W Kinzler
series ordinal
2
object named as
K W Kinzler
0 references
author name string
C Lengauer
series ordinal
1
0 references
language of work or name
English
0 references
publication date
17 December 1998
0 references
published in
Nature
0 references
volume
396
0 references
page(s)
643-9
0 references
issue
6712
0 references
cites work
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mutation rate and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic alterations in leukemias and lymphomas: impressive progress and continuing complexity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-mismatch repair. The intricacies of eukaryotic spell-checking.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic control of microsatellite stability.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective repair replication of DNA in xeroderma pigmentosum
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic Heterogeneity of Xeroderma Pigmentosum demonstrated by Somatic Cell Hybridization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA repair in eukaryotes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The origin of human cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endogenous mutagens and the causes of aging and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Microsatellite instability in cancer of the proximal colon
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clues to the pathogenesis of familial colorectal cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic mapping of a locus predisposing to human colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic mapping of a second locus predisposing to hereditary non–polyposis colon cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation of a mutL homolog in hereditary colon cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypermutability and mismatch repair deficiency in RER+ tumor cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations predisposing to hereditary nonpolyposis colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mismatch repair, genetic stability and tumour avoidance.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemistry and genetics of eukaryotic mismatch repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutator phenotypes in human colorectal carcinoma cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Allelotype of colorectal carcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic instability in colorectal cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of heterozygosity and base substitution at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytogenetic analysis of colorectal adenomas: karyotypic comparisons of synchronous tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A p53-dependent mouse spindle checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The genetics of cell cycle checkpoints.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
At the heart of the budding yeast cell cycle.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle checkpoints: preventing an identity crisis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
When checkpoints fail.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of mitotic checkpoint genes in human cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a human mitotic checkpoint gene: hsMAD2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM: from gene to function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BRCA1, BRCA2, and DNA damage response: collision or collusion?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Awakening angels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The centrosome--a tiny organelle with big potential
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Abnormal centrosome amplification in the absence of p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Primary vs. secondary neoplasia-associated chromosomal abnormalities--balanced rearrangements vs. genomic imbalances?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of p53 results in high rates of homologous recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F25292
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/25292
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
120255
Dimensions Publication ID
1033871070
0 references
OpenCitations bibliographic resource ID
120255
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
120255
PubMed ID
9872311
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
120255
ResearchGate publication ID
13416757
0 references
Springer Nature article ID
10.1038/25292
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit