(Q28137772)

English

EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis?

scientific article (publication date: 25 June 1999)

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scholarly article

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EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? (English)

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Thomas C. Südhof

3

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author name string

M Okamoto

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S Schoch

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language of work or name

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publication date

25 June 1999

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Journal of Biological Chemistry

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274

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18446-54

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26

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A molecular description of synaptic vesicle membrane trafficking

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Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic

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Synaptotagmins: C2-domain proteins that regulate membrane traffic

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Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits

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Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans.

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Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis.

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Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site

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Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

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Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon

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The role of clathrin, adaptors and dynamin in endocytosis

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Dap160, a neural-specific Eps15 homology and multiple SH3 domain-containing protein that interacts with Drosophila dynamin

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Synaptic vesicle endocytosis impaired by disruption of dynamin-SH3 domain interactions

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Mechanics of membrane fusion

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway

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The role of the PH domain and SH3 binding domains in dynamin function

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Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

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The dynamins: redundant or distinct functions for an expanding family of related GTPases?

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Developmentally regulated alternative splicing in a novel synaptojanin

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The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R

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Dynamin and its partners: a progress report

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Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins

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EH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin cytoskeleton and endocytosis in Saccharomyces cerevisiae.

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The synaptic vesicle cycle: a cascade of protein-protein interactions

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Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis

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EH: a novel protein-protein interaction domain potentially involved in intracellular sorting

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Mints, Munc18-interacting proteins in synaptic vesicle exocytosis

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A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.

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Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.

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Complexins: cytosolic proteins that regulate SNAP receptor function

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The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2

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Vesicle fusion from yeast to man

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Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain

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Functional interaction of the auxilin J domain with the nucleotide- and substrate-binding modules of Hsc70.

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The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein

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Stages of regulated exocytosis

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Protein kinesis: the dynamics of protein trafficking and stability. Summary

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The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain

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A presynaptic inositol-5-phosphatase

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A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution

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Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern

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Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues

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Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors.

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