(Q28137846)

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C Wirbelauer

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M Scheffner

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W Krek

How proteolysis drives the cell cycle

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language of work or name

English

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publication date

May 1999

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published in

Nature Cell Biology

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volume

1

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page(s)

14-9

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issue

1

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cites work

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7 January 2021

Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts

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7 January 2021

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.

1 reference

7 January 2021

Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein

1 reference

7 January 2021

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

1 reference

7 January 2021

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

1 reference

7 January 2021

Oncogenic capacity of the E2F1 gene

1 reference

7 January 2021

Multiple members of the E2F transcription factor family are the products of oncogenes

1 reference

7 January 2021

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1 reference

7 January 2021

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

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7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

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7 January 2021

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

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7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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7 January 2021

Tumor induction and tissue atrophy in mice lacking E2F-1

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7 January 2021

Ubiquitin-dependent protein degradation

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7 January 2021

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

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7 January 2021

A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p

1 reference

7 January 2021

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast

1 reference

7 January 2021

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

1 reference

7 January 2021

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

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7 January 2021

Proteolysis and the G1-S transition: the SCF connection

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7 January 2021

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins

1 reference

7 January 2021

Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

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7 January 2021

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

1 reference

7 January 2021

Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

1 reference

7 January 2021

Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

1 reference

7 January 2021

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

1 reference

7 January 2021

The regulation of E2F by pRB-family proteins

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7 January 2021

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

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7 January 2021

Differential regulation of E2F transactivation by cyclin/cdk2 complexes

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7 January 2021

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation

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7 January 2021

Cyclin A is required in S phase in normal epithelial cells.

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7 January 2021

Cyclin A is required at two points in the human cell cycle

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7 January 2021

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

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7 January 2021

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

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7 January 2021

Distinct roles for cyclin-dependent kinases in cell cycle control

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7 January 2021

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1 reference

7 January 2021

Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members

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7 January 2021

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

1 reference

7 January 2021