(Q28140069)

English

Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564

scientific article (publication date: April 1999)

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scholarly article

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Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564 (English)

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mitomycin C metabolic process

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Gene Ontology release 2020-05-02

Gene Ontology ID

mitomycin C catabolic process

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Gene Ontology release 2020-05-02

Gene Ontology ID

mitomycin C biosynthetic process

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Gene Ontology release 2020-05-02

Gene Ontology ID

Streptomyces lavendulae

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based on heuristic

inferred from title

author name string

Y Mao

1

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M Varoglu

2

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D H Sherman

3

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language of work or name

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publication date

April 1999

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Chemistry and Biology

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6

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251-63

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4

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online access status

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19 March 2024

https://api.unpaywall.org/v2/10.1016/s1074-5521(99)80040-4?email=unpaywall_01@example.com

access restriction status

1 reference

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inferred from online access status

The mitomycin bioreductive antitumor agents: cross-linking and alkylation of DNA as the molecular basis of their activity

1 reference

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Current issues in the enzymology of mitomycin C metabolic activation

1 reference

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FR900482, a close cousin of mitomycin C that exploits mitosene-based DNA cross-linking

1 reference

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Microbial mutagenicity and in vitro chromosome aberration induction by FK973, a new antitumor agent.

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FK317: a novel substituted dihydrobenzoxazine with potent antitumor activity which does not induce vascular leak syndrome

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1a-docosahexaenoyl mitomycin C: a novel inhibitor of protein tyrosine kinase

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3-Amino-5-hydroxybenzoic acid in antibiotic biosynthesis. VI. Directed biosynthesis studies with ansamycin antibiotics

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Studies on the Biosynthesis of Mitomycin C by Streptomyces verticillatus

1 reference

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Utilization of the intact carbamoyl group of L-(NH2CO-13C, 15N) citrulline in mitomycin biosynthesis by Streptomyces verticillatus

1 reference

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D-glucosamine and L-citrulline, precursors in mitomycin biosynthesis by Streptomyces verticillatus

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Natural products derived from unusual variants of the shikimate pathway

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Mitomycin C: small, fast and deadly (but very selective)

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Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae

1 reference

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Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae

1 reference

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3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.

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The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces

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Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system

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10.1016/S1074-5521(99)80040-4

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