(Q28140835)

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HIF-1: mediator of physiological and pathophysiological responses to hypoxia

scientific article (publication date: April 2000)

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title

HIF-1: mediator of physiological and pathophysiological responses to hypoxia (English)

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G L Semenza

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language of work or name

English

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publication date

April 2000

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published in

Journal of Applied Physiology

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volume

88

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page(s)

1474-80

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issue

4

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cites work

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

Remembrance of things PAS: regulation of development by bHLH-PAS proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Identification of a hypoxia response element in the transferrin receptor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Expression of ARNT, ARNT2, HIF1 alpha, HIF2 alpha and Ah receptor mRNAs in the developing mouse.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Perspectives on oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

The biology of vascular endothelial growth factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Gene expression profiles in normal and cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Positional cloning of the mouse circadian clock gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

Purification and characterization of hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1152/JAPPL.2000.88.4.1474

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DOI

10.1152/JAPPL.2000.88.4.1474

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OpenCitations bibliographic resource ID

1212409

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1212409

(Q28140835)

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

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