(Q28145949)

1

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M Tanaka

2

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Y Otsuki

3

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D Y Wang

4

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R J Guo

5

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Y Zhu

6

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R Takeda

7

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H Hanai

8

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E Kaneko

9

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H Sugimura

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

10

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language of work or name

English

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publication date

7 October 1999

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published in

Oncogene

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volume

18

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page(s)

5680-90

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issue

41

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cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

A novel regulator of p21-activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

The Xenopus platelet-derived growth factor alpha receptor: cDNA cloning and demonstration that mesoderm induction establishes the lineage-specific pattern of ligand and receptor gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Xenopus Gastrulation without a blastocoel roof

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Primary structure and developmental expression of a large cytoplasmic domain form of Xenopus laevis neural cell adhesion molecule (NCAM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

PAK promotes morphological changes by acting upstream of Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Interaction of EphB2-tyrosine kinase receptor and its ligand conveys dorsalization signal in Xenopus laevis development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Cell cycle-dependent activation of Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Rho family GTPases bind to phosphoinositide kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Guanine nucleotide exchange catalyzed by dbl oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936

Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202936