(Q28176737)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

review article

1 reference

title

Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

Avi Ashkenazi

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

language of work or name

English

0 references

publication date

1 June 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

Cytokine and Growth Factor Reviews

4 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

337-348

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

issue

3-4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

4 November 2019

cites work

1 reference

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7 January 2021

Identification and characterization of a new member of the TNF family that induces apoptosis

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7 January 2021

The receptor for the cytotoxic ligand TRAIL

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7 January 2021

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

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7 January 2021

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

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7 January 2021

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

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7 January 2021

Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL

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7 January 2021

Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

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7 January 2021

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

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7 January 2021

Characterization of two receptors for TRAIL

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7 January 2021

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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7 January 2021

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

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7 January 2021

A novel receptor for Apo2L/TRAIL contains a truncated death domain

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7 January 2021

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

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7 January 2021

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

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7 January 2021

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

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7 January 2021

Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

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7 January 2021

Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor

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7 January 2021

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

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7 January 2021

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

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7 January 2021

A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

1 reference

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7 January 2021

Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL

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7 January 2021

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

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7 January 2021

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

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7 January 2021

Avoiding premature apoptosis of normal epidermal cells

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7 January 2021

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

1 reference

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7 January 2021

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

1 reference

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7 January 2021

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

1 reference

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7 January 2021

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

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7 January 2021

Caspase-10 is an initiator caspase in death receptor signaling

1 reference

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7 January 2021

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

1 reference

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7 January 2021

Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

1 reference

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7 January 2021

A matter of life and death

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7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

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7 January 2021

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

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7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

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7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis

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7 January 2021

Apo2L/TRAIL and its death and decoy receptors

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7 January 2021

TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2.

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7 January 2021

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

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7 January 2021

Bcl-2 over-expression and activation of protein kinase C suppress the trail-induced apoptosis in Jurkat T cells

1 reference

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7 January 2021

Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60.

1 reference

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7 January 2021

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

1 reference

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7 January 2021

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

1 reference

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7 January 2021

TRAIL-induced eradication of primary tumour cells from multiple myeloma patient bone marrows is not related to TRAIL receptor expression or prior chemotherapy

1 reference

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7 January 2021

Differential localization and regulation of death and decoy receptors for TNF-related apoptosis-inducing ligand (TRAIL) in human melanoma cells

1 reference

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7 January 2021

Inhibition of fas death signals by FLIPs

1 reference

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7 January 2021

Inhibition of death receptor signals by cellular FLIP

1 reference

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7 January 2021

An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

1 reference

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7 January 2021

Intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human multiple myeloma cells

1 reference

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7 January 2021

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

1 reference

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7 January 2021

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

1 reference

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7 January 2021

IAP proteins: blocking the road to death's door

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

IFN-beta pretreatment sensitizes human melanoma cells to TRAIL/Apo2 ligand-induced apoptosis

1 reference

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7 January 2021

Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis

1 reference

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7 January 2021

NF-kappaB in cancer: from innocent bystander to major culprit

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7 January 2021

Activation of protein kinase C inhibits TRAIL-induced caspases activation, mitochondrial events and apoptosis in a human leukemic T cell line

1 reference

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7 January 2021

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells

1 reference

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7 January 2021

MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors

1 reference

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7 January 2021

Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance

1 reference

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7 January 2021

Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Three polymorphisms in the 3' UTR of the TRAIL (TNF-related apoptosis-inducing ligand) gene

1 reference

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7 January 2021

Human myeloma cell apoptosis induced by interferon-alpha

1 reference

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7 January 2021

Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis

1 reference

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7 January 2021

Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma

1 reference

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7 January 2021

Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics

1 reference

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7 January 2021

Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells

1 reference

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7 January 2021

How cells respond to interferons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Genomic organization and transcriptional regulation of human Apo2/TRAIL gene.

1 reference

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7 January 2021

Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

1 reference

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7 January 2021

Death and survival: viral regulation of TNF signaling pathways

1 reference

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7 January 2021

Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis

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7 January 2021

PKR; a sentinel kinase for cellular stress

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7 January 2021

Mitochondria-dependent and -independent mechanisms in tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis are both regulated by interferon-gamma in human breast tumour cells.

1 reference

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7 January 2021

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice

1 reference

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7 January 2021

Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta

1 reference

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7 January 2021

Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL.

1 reference

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7 January 2021

REGULATION OF APO-2 LIGAND/TRAIL EXPRESSION IN NK CELLS—INVOLVEMENT IN NK CELL-MEDIATED CYTOTOXICITY

1 reference

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7 January 2021

Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: A novel mechanism for the antitumor effects of type I IFNs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

1 reference

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7 January 2021

TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Safety and antitumor activity of recombinant soluble Apo2 ligand

1 reference

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7 January 2021

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

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7 January 2021

Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

1 reference

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7 January 2021

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Antitumor activity and prolonged expression from a TRAIL-expressing adenoviral vector

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2803%2900029-7

7 January 2021

10.1016/S1359-6101(03)00029-7

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

573459

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

573459

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

573459