(Q28185671)

English

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

scientific article (publication date: 6 February 2004)

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scholarly article

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A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex (English)

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author name string

Sheu-Fen Lee

1

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Sanjiv Shah

2

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Cong Yu

3

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W Christian Wigley

4

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Harry Li

5

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Myungsil Lim

6

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Kia Pedersen

7

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Weiping Han

8

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Philip Thomas

9

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Johan Lundkvist

10

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Yi-Heng Hao

11

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Gang Yu

12

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language of work or name

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publication date

6 February 2004

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Journal of Biological Chemistry

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279

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4144-52

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6

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

A dimerization motif for transmembrane α–helices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

A transmembrane helix dimer: structure and implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Helical membrane protein folding, stability, and evolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

The GxxxG motif: a framework for transmembrane helix-helix association

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Cellular mechanisms of beta-amyloid production and secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

In vivo detection of hetero-association of glycophorin-A and its mutants within the membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Helical membrane proteins: diversity of functions in the context of simple architecture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Structural determinants of water permeation through aquaporin-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

The GxxxG motif of the transmembrane domain of subunit e is involved in the dimerization/oligomerization of the yeast ATP synthase complex in the mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

The single transmembrane domains of ErbB receptors self-associate in cell membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309745200

21 January 2018

Identifiers

10.1074/JBC.M309745200

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