(Q28187880)

ORCID Public Data File 2021

Bart Vanhaesebroeck

series ordinal

2

object named as

Bart Vanhaesebroeck

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language of work or name

English

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publication date

April 2003

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published in

Nature Reviews Immunology

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volume

3

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page(s)

317-30

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issue

4

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cites work

Synthesis and function of 3-phosphorylated inositol lipids

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Phosphoinositide 3-kinases: a conserved family of signal transducers

31 March 2020

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Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

31 March 2020

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Tec family kinases in lymphocyte signaling and function

31 March 2020

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The role of phosphoinositides in membrane transport

31 March 2020

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PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.

31 March 2020

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

31 March 2020

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Immunosuppressive Effects of Dietary Wortmannin on Rats and Mice

31 March 2020

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Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum

31 March 2020

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Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

31 March 2020

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Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

31 March 2020

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

31 March 2020

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Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.

31 March 2020

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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

31 March 2020

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Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

31 March 2020

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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

31 March 2020

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Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

31 March 2020

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Role of the PI3K regulatory subunit in the control of actin organization and cell migration

31 March 2020

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Phosphatidylinositol 3-kinase p85 adaptor function in T-cells. Co-stimulation and regulation of cytokine transcription independent of associated p110.

31 March 2020

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Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

31 March 2020

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A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

31 March 2020

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Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

31 March 2020

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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

31 March 2020

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Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

31 March 2020

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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

31 March 2020

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Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

31 March 2020

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Resistance to thromboembolism in PI3Kgamma-deficient mice.

31 March 2020

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Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

31 March 2020

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Phosphoinositide 3-kinases in immunity: lessons from knockout mice

31 March 2020

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PI3K-signalling in B- and T-cells: insights from gene-targeted mice

31 March 2020

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Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

31 March 2020

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Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk

31 March 2020

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CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase

31 March 2020

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The physiologic role of CD19 cytoplasmic tyrosines

31 March 2020

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CD19 function in early and late B cell development: I. Maintenance of follicular and marginal zone B cells requires CD19-dependent survival signals

31 March 2020

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The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21

31 March 2020

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CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes

31 March 2020

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Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction

31 March 2020

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Cd19-dependent activation of Akt kinase in B-lymphocytes

31 March 2020

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A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane

31 March 2020

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Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

31 March 2020

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The dynamics of protein kinase B regulation during B cell antigen receptor engagement

31 March 2020

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31 March 2020

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Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement

31 March 2020

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Essential immunoregulatory role for BCAP in B cell development and function

31 March 2020

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

31 March 2020

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Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

31 March 2020

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PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

31 March 2020

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Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

31 March 2020

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Btk function in B cell development and response.

31 March 2020

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Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway

31 March 2020

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PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals.

31 March 2020

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Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

31 March 2020

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Regulation of Btk function by a major autophosphorylation site within the SH3 domain

31 March 2020

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In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

31 March 2020

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Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes

31 March 2020

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A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase

31 March 2020

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The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival

31 March 2020

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Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase

31 March 2020

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

31 March 2020

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

31 March 2020

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Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity

31 March 2020

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Signal-dependent membrane targeting by pleckstrin homology (PH) domains

31 March 2020

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A requirement for lipid rafts in B cell receptor induced Ca(2+) flux

31 March 2020

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FcgammaRIIb modulation of surface immunoglobulin-induced Akt activation in murine B cells

31 March 2020

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SHIP modulates immune receptor responses by regulating membrane association of Btk.

31 March 2020

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Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

31 March 2020

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The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

31 March 2020

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Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

31 March 2020

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Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP)

31 March 2020

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TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor

31 March 2020

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Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

31 March 2020

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

31 March 2020

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The lineage decisions of helper T cells

31 March 2020

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31 March 2020

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Three-dimensional segregation of supramolecular activation clusters in T cells

31 March 2020

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31 March 2020

The B7-CD28 superfamily

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Xid-like phenotypes: a B cell signalosome takes shape

31 March 2020

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Regulatory T cells in the control of immune pathology.

31 March 2020

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Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

31 March 2020

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Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

31 March 2020

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Mutation of Tec family kinases alters T helper cell differentiation

31 March 2020

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Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

31 March 2020

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Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

31 March 2020

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Imaging antigen-induced PI3K activation in T cells

31 March 2020

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Phosphoinositide 3-kinases in T lymphocyte activation

31 March 2020

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T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane

31 March 2020

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

31 March 2020

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Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

31 March 2020

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Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction

31 March 2020

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Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells

31 March 2020

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T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

31 March 2020

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Itk negatively regulates induction of T cell proliferation by CD28 costimulation

31 March 2020

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Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

31 March 2020

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Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

31 March 2020

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T lymphocyte costimulation mediated by reorganization of membrane microdomains

31 March 2020

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Membrane compartmentation is required for efficient T cell activation.

31 March 2020

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PI 3-kinase: a pivotal pathway in T-cell activation?

31 March 2020

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Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

31 March 2020

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A point mutation in CD28 distinguishes proliferative signals from survival signals

31 March 2020

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Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo

31 March 2020

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Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.

31 March 2020

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

31 March 2020

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

31 March 2020

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Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes

31 March 2020

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Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling

31 March 2020

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Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction

31 March 2020

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Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation

31 March 2020

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Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association

31 March 2020

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T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif

31 March 2020

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Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells

31 March 2020

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Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

31 March 2020

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Regulation of Lck activity by CD4 and CD28 in the immunological synapse

31 March 2020

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

31 March 2020

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Regulatory intramolecular association in a tyrosine kinase of the Tec family

31 March 2020

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Requirement for CD28 co-stimulation is lower in SHP-1-deficient T cells

31 March 2020

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The CD28 signaling pathway regulates glucose metabolism

31 March 2020

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

31 March 2020

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

31 March 2020

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Impaired Fas response and autoimmunity in Pten+/- mice

31 March 2020

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

31 March 2020

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Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors

31 March 2020

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

31 March 2020

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PI3-kinase inhibition: a target for drug development?

31 March 2020

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Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

31 March 2020

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Rho family GTPases bind to phosphoinositide kinases

31 March 2020

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

31 March 2020

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The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

31 March 2020

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B cell development pathways

31 March 2020

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Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-kappa B activation in primary B cells

31 March 2020

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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

31 March 2020

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Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40-mediated proliferation and survival pathways

31 March 2020

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A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.

31 March 2020

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Regulation of B-cell signal transduction by adaptor proteins

31 March 2020

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The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase

31 March 2020

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It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.

31 March 2020

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Tor signalling in bugs, brain and brawn

31 March 2020

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Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1056

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Consolidated OpenCitations Corpus – April 2017

2389442

2389442

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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