(Q28191975)

7 January 2021

New drug development in the United States from 1963 to 1990.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Understanding clinical trials.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

DNA chips: promising toys have become powerful tools

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Microarrays and toxicology: the advent of toxicogenomics

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Revolution through genomics in investigative and discovery toxicology

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

The impact of genomics-based technologies on drug safety evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Integrating computer prediction systems with in vitro methods towards a better understanding of toxicology

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Knowledge-based expert systems for toxicity and metabolism prediction: DEREK, StAR and METEOR.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Modeling the toxicity of chemicals to Tetrahymena pyriformis using molecular fragment descriptors and probabilistic neural networks

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Development and validation of a genetic algorithm for flexible docking

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Distributed automated docking of flexible ligands to proteins: Parallel applications of AutoDock 2.4

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

The computer program LUDI: a new method for the de novo design of enzyme inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

A fast flexible docking method using an incremental construction algorithm.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Hammerhead: fast, fully automated docking of flexible ligands to protein binding sites.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

HOOK: a program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

QXP: powerful, rapid computer algorithms for structure-based drug design

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Flexible docking using Tabu search and an empirical estimate of binding affinity.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Flexible ligand docking using conformational ensembles

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Bridging the protein sequence-structure gap by structure predictions

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

100,000 protein structures for the biologist

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

A geometric approach to macromolecule-ligand interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Mitochondrial targets of drug toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

The pharmacology and toxicology of polyphenolic-glutathione conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Immunotoxic side-effects of drug therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Pharmacodynamics and toxicodynamics of drug action: signaling in cell survival and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Galactosemia: screening and diagnosis

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Glycogen storage diseases. Phenotypic, genetic, and biochemical characteristics, and therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Molecular analysis and prenatal diagnosis of human fumarase deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Inhibition of the genotoxicity of bleomycin by superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Glutathione peroxidase and catalase modulate the genotoxicity of arsenite

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Mitochondrial disease in mouse results in increased oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Effects of short-chain acyl-CoA dehydrogenase deficiency on development expression of metabolic enzyme genes in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

The neurochemistry of phenylketonuria.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Leu-enkephalin, tamoxifen and ethanol interactions: effects on motility and hepatic ethanol metabolizing enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Differential in vivo and in vitro effect of gentamicin on glutamate synthesis and glutamate deamination in rabbit kidney-cortex tubules and mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Effect of decreased glutathione levels in hereditary glutathione synthetase deficiency on dibromoethane-induced genotoxicity in human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Acute Toxicity of Three New Selective COMT Inhibitors in Mice with Special Emphasis on Interactions with Drugs Increasing Catecholaminergic Neurotransmission

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

The mechanism for the inhibition of acetylcholinesterases by irinotecan (CPT-11).

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Hyperglycemia associated with protease inhibitors in an urban HIV-infected minority patient population

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Effect of geranylgeranylacetone on aspirin-induced changes in gastric glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Protective effects of vitamin e and probucol against gentamicin-induced nephrotoxicity in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Gentamicin-induced nephrotoxicosis in lambs

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Alterations in lysosomal enzymes of the proximal tubule in gentamicin nephrotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Gentamicin inhibition of Na+,K(+)-ATPase in rat kidney cells

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

The effects of tumor necrosis factor and their selective inhibition by ibuprofen

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Human immunodeficiency virus protease inhibitors serve as substrates for multidrug transporter proteins MDR1 and MRP1 but retain antiviral efficacy in cell lines expressing these transporters

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Aminoglycoside neurotoxicity involves NMDA receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Areas, volumes, packing and protein structure

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

The role of a minor groove spine of hydration in stabilizing poly(dA). poly(dT) against fuctuational interbase H-bond disruption in the premelting temperature regime

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Premelting base pair opening probability and drug binding constant of a daunomycin-poly d(GCAT).poly d(ATGC) complex

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Chem-X and CAMBRIDGE. Comparison of computer generated chemical structures with X-ray crystallographic data

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Mechanism of the aspirin-induced rise in blood alcohol levels

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

The mechanism of inhibition of beta-oxidation by aspirin metabolites in skin fibroblasts from Reye's syndrome patients and controls

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Acetylation of antithrombin III by aspirin

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Great variation in the response of tissue plasminogen activator activity, plasminogen activator inhibition and plasmin inhibition to endotoxin, aspirin and endotoxin after administration of aspirin

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Aspirin Causes Tissue Insensitivity to Insulin In Normal Man*

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Effects of peroxisome proliferators on fatty acid-binding protein in rat liver

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Role of DL ?-lipoic acid in gentamicin induced nephrotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Acute Poisoning Due to Non-Steroidal Anti-Inflammatory Drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Platelet-derived Growth Factor-BB and Thrombin Generate Positive and Negative Signals for Human Hepatic Stellate Cell Proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Interactions of ibuprofen with influenza infection and hyperammonemia in an animal model of Reye's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Stimulation of vitamin A(1) acid signaling by the HIV protease inhibitor indinavir

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Nephrotoxicity screening in rats: a validation study

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Inhibition of RNase P RNA cleavage by aminoglycosides

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Cytoskeletal protein mRNA expression in the chick utricle after treatment in vitro with aminoglycoside antibiotics: effects of insulin, iron chelators and cyclic nucleotides.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Semisynthetic beta-lactam antibiotics. III. Effect on antibacterial activity and comt-susceptibility of chlorine-introduction into the catechol nucleus of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2- phenylacetamido]penicillan

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Steroidal and nonsteroidal oestrogen antagonists in breast cancer: basic and clinical appraisal

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

High-dose vitamin C: a risk for persons with high iron stores?

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Ascorbic acid-based inhibitors of alpha-amylases

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Inactivation of purified phenylalanine hydroxylase by dithiothreitol

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Site-specific modifications and toxicity of blood substitutes. The case of diaspirin cross-linked hemoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Immunochemical identification of mouse hepatic protein adducts derived from the nonsteroidal anti-inflammatory drugs diclofenac, sulindac, and ibuprofen

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Persistent acylation of high-molecular-weight penicillin-binding proteins by penicillin induces the postantibiotic effect in Streptococcus pyogenes

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Predicting function: from genes to genomes and back

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021

Mathematical simulation and analysis of cellular metabolism and regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1093-3263%2801%2900109-7

7 January 2021