(Q28201086)

12 December 2020

Are the orally administered proton pump inhibitors equivalent? A comparison of lansoprazole, omeprazole, pantoprazole, and rabeprazole

1 reference

12 December 2020

Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19.

1 reference

12 December 2020

Mephenytoin hydroxylation in the Cuna Amerindians of Panama

1 reference

12 December 2020

Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite

1 reference

12 December 2020

Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine

1 reference

12 December 2020

Diazepam-cimetidine drug interaction: a clinically significant effect

1 reference

12 December 2020

Interethnic difference in omeprazole's inhibition of diazepam metabolism.

1 reference

12 December 2020

Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples

1 reference

12 December 2020

Theophylline pharmacokinetics are not altered by lansoprazole in CYP2C19 poor metabolizers

1 reference

12 December 2020

Stereospecific analysis of omeprazole supports artemisinin as a potent inducer of CYP2C19

1 reference

12 December 2020

Evidence for the effect of gender on activity of (S)-mephenytoin 4'-hydroxylase (CYP2C19) in a Chinese population.

1 reference

12 December 2020

Genetic polymorphism of debrisoquine (CYP2D6) and proguanil (CYP2C19) in South Pacific Polynesian populations

1 reference

12 December 2020

Genetic polymorphism of the hepatic cytochrome P450 2C19 in north Indian subjects

1 reference

12 December 2020

Clinical pharmacology. Blue-chip technology.

1 reference

12 December 2020

1 reference

12 December 2020

Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation

1 reference

12 December 2020

Dose dependent induction of CYP1A2 activity by omeprazole (Antra)

1 reference

12 December 2020

Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian population

1 reference

12 December 2020

Cure of refractory duodenal ulcer and infection caused by Helicobacter pylori by high doses of omeprazole and amoxicillin in a homozygous CYP2C19 extensive metabolizer patient

1 reference

12 December 2020

Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19

1 reference

12 December 2020

Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers

1 reference

12 December 2020

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

1 reference

12 December 2020

Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms

1 reference

12 December 2020

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

1 reference

12 December 2020

Interaction studies with moclobemide

1 reference

12 December 2020

Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide*

1 reference

12 December 2020

Human CYP2C-mediated stereoselective phenytoin hydroxylation in Japanese: difference in chiral preference of CYP2C9 and CYP2C19

1 reference

12 December 2020

Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism

1 reference

12 December 2020

Dapsone N-acetylation, metoprolol alpha-hydroxylation, and S-mephenytoin 4-hydroxylation polymorphisms in an Indonesian population: a cocktail and extended phenotyping assessment trial

1 reference

12 December 2020

Lack of pantoprazole drug interactions in man: an updated review

1 reference

12 December 2020

CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system

1 reference

12 December 2020

Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazole

1 reference

12 December 2020

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1 reference

12 December 2020

Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes

1 reference

12 December 2020

Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms

1 reference

12 December 2020

Debrisoquine and mephenytoin oxidation in Sinhalese: a population study

1 reference

12 December 2020

Fluoxetine-imipramine interaction

1 reference

12 December 2020

Clinical Pharmacokinetics of Diazepam

1 reference

12 December 2020

CYP2C19 genotype-related efficacy of omeprazole for the treatment of infection caused by Helicobacter pylori

1 reference

12 December 2020

Genetic polymorphism of S-mephenytoin 4'-hydroxylation.

1 reference

12 December 2020

Biliary excretion of intravenous [14C] omeprazole in humans

1 reference

12 December 2020

The effect of antipyrine and rifampin on the metabolism of diazepam.

1 reference

12 December 2020

Polymorphism in hydroxylation of mephenytoin and hexobarbital stereoisomers in relation to hepatic P-450 human-2

1 reference

12 December 2020

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles

1 reference

12 December 2020

A mechanistic approach to antiepileptic drug interactions

1 reference

12 December 2020

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase

1 reference

12 December 2020

Phenotyping and genotyping of S-mephenytoin hydroxylase (cytochrome P450 2C19) in a Shona population of Zimbabwe

1 reference

12 December 2020

CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans

1 reference

12 December 2020

Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study*

1 reference

12 December 2020

Scleroderma is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquin, and mephenytoin

1 reference

12 December 2020

Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype

1 reference

12 December 2020

S-mephenytoin hydroxylation phenotypes in a Jordanian population

1 reference

12 December 2020

Warfarin-fluoxetine and diazepam-fluoxetine interaction

1 reference

12 December 2020

The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions

1 reference

12 December 2020

Cobalamin deficiency with megaloblastic anaemia in one patient under long-term omeprazole therapy

1 reference

12 December 2020

Biochemistry and molecular biology of the human CYP2C subfamily

1 reference

12 December 2020

Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.

1 reference

12 December 2020

Extent of urinary excretion of p-hydroxyphenytoin in healthy subjects given phenytoin

1 reference

12 December 2020

The induction effect of rifampicin on activity of mephenytoin 4'-hydroxylase related to M1 mutation of CYP2C19 and gene dose

1 reference

12 December 2020

Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A

1 reference

12 December 2020

Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism

1 reference

12 December 2020

Centrally acting oral skeletal muscle relaxants

1 reference

12 December 2020

Oxidative metabolism of lansoprazole by human liver cytochromes P450.

1 reference

12 December 2020

Concurrent use of more than one major psychotropic drug (polypsychopharmacy) in out-patients--a prescription database study

1 reference

12 December 2020

The cardiac effects of therapeutic plasma concentrations of imipramine

1 reference

12 December 2020

Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs

1 reference

12 December 2020

Frequency of impaired mephenytoin 4'-hydroxylation in an Indian population

1 reference

12 December 2020

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.

1 reference

12 December 2020

Inhibition by omeprazole of proguanil metabolism: mechanism of the interaction in vitro and prediction of in vivo results from the in vitro experiments

1 reference

12 December 2020

Sufficient effect of 1-week omeprazole and amoxicillin dual treatment for Helicobacter pylori eradication in cytochrome P450 2C19 poor metabolizers

1 reference

12 December 2020

Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19

1 reference

12 December 2020

Clinical implications of imipramine plasma levels for depressive illness

1 reference

12 December 2020

The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism

1 reference

12 December 2020

Non-response to citalopram in depressive patients: pharmacokinetic and clinical consequences of a fluvoxamine augmentation

1 reference

12 December 2020

A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer

1 reference

12 December 2020

The genetic defect of mephenytoin hydroxylation

1 reference

12 December 2020

Artemisinin induces omeprazole metabolism in human beings

1 reference

12 December 2020

Differences in diazepam pharmacokinetics in Chinese and white Caucasians--relation to body lipid stores.

1 reference

12 December 2020

Phenotypes and genotypes for CYP2D6 and CYP2C19 in a black Tanzanian population.

1 reference

12 December 2020

Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevity

1 reference

12 December 2020

Mephenytoin disposition and serum bile acids as indices of hepatic function in chronic viral hepatitis

1 reference

12 December 2020

Pharmacokinetic optimisation of the treatment of psychosis

1 reference

12 December 2020

Family studies of mephenytoin hydroxylation deficiency

1 reference

12 December 2020

Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment

1 reference

12 December 2020

Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies

1 reference

12 December 2020

CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages

1 reference

12 December 2020

Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms

1 reference

12 December 2020

Imipramine demethylation in vivo: Impact of CYP1A2, CYP2C19, and CYP3A4*

1 reference

12 December 2020

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

1 reference

12 December 2020

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.

1 reference

12 December 2020

Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin

1 reference

12 December 2020

Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications

1 reference

12 December 2020

Selective and potent inhibition of human CYP2C19 activity by a conformationally targeted antipeptide antibody

1 reference

12 December 2020

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva.

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Possible interaction between imipramine and butalbital

1 reference

12 December 2020

Metabolic characterization of the major human small intestinal cytochrome p450s

1 reference

12 December 2020

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1 reference

12 December 2020

Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction

1 reference

12 December 2020

Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations

1 reference

12 December 2020

No interaction of diazepam on amitriptyline disposition in depressed patients.

1 reference

12 December 2020

Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole

1 reference

12 December 2020

Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil

1 reference

12 December 2020

Isoniazid drug and food interactions

1 reference

12 December 2020

N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors

1 reference

12 December 2020

Effects of genetic defects in the CYP2C19 gene on the N-demethylation of imipramine, and clinical outcome of imipramine therapy

1 reference

12 December 2020

Genetic polymorphism of (S)-mephenytoin 4'-hydroxylation in populations of African descent

1 reference

12 December 2020

Pharmacokinetic fluvoxamine-clomipramine interaction with favorable therapeutic consequences in therapy-resistant depressive patient

1 reference

12 December 2020

Fatality associated with combined fluoxetine-amitriptyline therapy

1 reference

12 December 2020

Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy

1 reference

12 December 2020

Debrisoquine and S-mephenytoin hydroxylation polymorphisms in a Russian population living in Estonia

1 reference

12 December 2020

Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19.

1 reference

12 December 2020

S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin

1 reference

12 December 2020

Cimetidine interaction with imipramine and nortriptyline

1 reference

12 December 2020

Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease

1 reference

12 December 2020

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

1 reference

12 December 2020

Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects

1 reference

12 December 2020

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

1 reference

12 December 2020

Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro.

1 reference

12 December 2020

Polymorphic drug metabolism.

1 reference

12 December 2020

Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans

1 reference

12 December 2020

Stereoselective metabolism and disposition of the enantiomers of mephenytoin during chronic oral administration of the racemic drug in man

1 reference

12 December 2020

Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations

1 reference

12 December 2020

Imipramine metabolism in relation to the sparteine oxidation polymorphism - a family study

1 reference

12 December 2020

No correlation between side-chain of propranolol oxidation and S-mephenytoin 4'-hydroxylase activity

1 reference

12 December 2020

Genetic polymorphism of S-mephenytoin 4'-hydroxylation in African-Americans

1 reference

12 December 2020

Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole.

1 reference

12 December 2020

Oral phenytoin pharmacokinetics during omeprazole therapy

1 reference

12 December 2020

Molecular basis of ethnic differences in drug disposition and response

1 reference

12 December 2020

Clinical importance of the interaction of diazepam and cimetidine.

1 reference

12 December 2020

Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19.

1 reference

12 December 2020

Pharmacokinetic interactions between antiepileptic drugs. Clinical considerations

1 reference

12 December 2020

Seizures and myoclonus associated with antidepressant treatment: assessment of potential risk factors, including CYP2D6 and CYP2C19 polymorphisms, and treatment with CYP2D6 inhibitors

1 reference

12 December 2020

Pharmacogenetic determination of the effects of codeine and prediction of drug interactions

1 reference

12 December 2020

A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli.

1 reference

12 December 2020

Phenotyping polymorphic drug metabolism in the French Caucasian population

1 reference

12 December 2020

Heterologous expression and kinetic characterization of human cytochromes P-450: validation of a pharmaceutical tool for drug metabolism research

1 reference

12 December 2020

Metabolic disposition of lansoprazole in relation to the S-mephenytoin 4'-hydroxylation phenotype status

1 reference

12 December 2020

Phenotypic-genotypic analysis of CYP2C19 in the Jewish Israeli population

1 reference

12 December 2020

The hydroxylation of omeprazole correlates with S-mephenytoin and proguanil metabolism

1 reference

12 December 2020

The relationship between phenytoin pharmacokinetics and the CYP2C19 genotype in Japanese epileptic patients.

1 reference

12 December 2020

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

1 reference

12 December 2020

Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies*

1 reference

12 December 2020

Comparison of chloroguanide and mephenytoin for the in vivo assessment of genetically determined CYP2C19 activity in humans.

1 reference

12 December 2020

Cimetidine interaction with amitriptyline

1 reference

12 December 2020

Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin

1 reference

12 December 2020

CYP2D6 and CYP2C19 genotypes in an elderly Swedish population

1 reference

12 December 2020

Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole

1 reference

12 December 2020

Cytochrome P450 isozymes and antiepileptic drug interactions

1 reference

12 December 2020

Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans

1 reference

12 December 2020

Genotype analysis of the CYP2C19 gene in HCV-seropositive patients with cirrhosis and hepatocellular carcinoma

1 reference

12 December 2020

Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily

1 reference

12 December 2020

Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations

1 reference

12 December 2020

Elevation of steady-state diazepam levels by cimetidine.

1 reference

12 December 2020

Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation.

1 reference

12 December 2020

The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics

1 reference

12 December 2020

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

1 reference

12 December 2020

Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole

1 reference

12 December 2020

Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation

1 reference

12 December 2020

Influence of lansoprazole treatment on diazepam plasma concentrations

1 reference

12 December 2020

Selective serotonin reuptake inhibitors and tricyclic antidepressants in combination. Interactions and therapeutic uses

1 reference

12 December 2020

The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6

1 reference

12 December 2020

Antidepressants and drug-metabolizing enzymes--expert group report

1 reference

12 December 2020

Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers

1 reference

12 December 2020

Sparteine and mephenytoin oxidation: genetic polymorphisms in east and west Greenland

1 reference

12 December 2020

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

1 reference

12 December 2020

The hydroxylation of omeprazole correlates with S-mephenytoin metabolism: a population study

1 reference

12 December 2020

Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors

1 reference

12 December 2020

Induction of imipramine metabolism following barbiturate administration [proceedings]

1 reference

12 December 2020

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1 reference

12 December 2020

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1 reference

12 December 2020

Diazepam-omeprazole inhibition interaction: an in vitro investigation using human liver microsomes

1 reference

12 December 2020

RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver

1 reference

12 December 2020

Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin

1 reference

12 December 2020

Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin

1 reference

12 December 2020

Effect of omeprazole on the metabolism of cilostazol

1 reference

12 December 2020

Pharmacogenetics of mephenytoin: a new drug hydroxylation polymorphism in man

1 reference

12 December 2020

The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides

1 reference

12 December 2020

Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test

1 reference

12 December 2020

Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4

1 reference

12 December 2020

A study of the interaction between omeprazole and phenytoin in epileptic patients

1 reference

12 December 2020

Pharmacokinetic considerations in the eradication of Helicobacter pylori

1 reference

12 December 2020

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes

1 reference

12 December 2020

Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.

1 reference

12 December 2020

Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.

1 reference

12 December 2020

Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers.

1 reference

12 December 2020

Possible association between poor metabolism of mephenytoin and hepatotoxicity caused by Atrium, a fixed combination preparation containing phenobarbital, febarbamate and difebarbamate

1 reference

12 December 2020

Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound: Investigative reports

1 reference

12 December 2020

S-mephenytoin, sparteine and debrisoquine oxidation: genetic polymorphisms in a Turkish population

1 reference

12 December 2020

Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model.

1 reference

12 December 2020

Interphenotype differences in disposition and effect on gastrin levels of omeprazole--suitability of omeprazole as a probe for CYP2C19

1 reference

12 December 2020

Role of cytochrome P450 in estradiol metabolism in vitro.

1 reference

12 December 2020

Allele frequency of CYP2C19 in a Portuguese population

1 reference

12 December 2020

Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction

1 reference

12 December 2020

Four-week treatment with omeprazole increases the metabolism of caffeine

1 reference

12 December 2020

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways

1 reference

12 December 2020

Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

1 reference

12 December 2020

Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: implications for diazepam disposition in humans.

1 reference

12 December 2020

CYP2C19 genotype and phenotype determined by omeprazole in a Korean population

1 reference

12 December 2020

CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes

1 reference

12 December 2020

Lung cancer risk in relation to mephenytoin hydroxylation activity

1 reference

12 December 2020

Proguanil polymorphism does not affect the antimalarial activity of proguanil combined with atovaquone in vitro.

1 reference

12 December 2020

Determination of CYP2C19 phenotype in black Americans with omeprazole: correlation with genotype.

1 reference

12 December 2020

Efficacy of triple therapy with rabeprazole for Helicobacter pylori infection and CYP2C19 genetic polymorphism

1 reference

12 December 2020

The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype

1 reference

12 December 2020

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1 reference

12 December 2020

Ticlopidine inhibits phenytoin clearance

1 reference

12 December 2020

Lack of drug interaction between omeprazole, lansoprazole, pantoprazole and theophylline

1 reference

12 December 2020

Proton pump inhibitory therapy: then and now.

1 reference

12 December 2020

The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel.

1 reference

12 December 2020

S-mephenytoin 4-hydroxylation in older Americans

1 reference

12 December 2020

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6

1 reference

12 December 2020

Genetic analysis of the S-mephenytoin polymorphism in a Chinese population

1 reference

12 December 2020

Enantioselective disposition of lansoprazole in extensive and poor metabolizers of CYP2C19.

1 reference

12 December 2020

CYP2C19 genotyping and associated mephenytoin hydroxylation polymorphism in a Canadian Inuit population

1 reference

12 December 2020

Effect of the CYP2C19 oxidation polymorphism on fluoxetine metabolism in Chinese healthy subjects

1 reference

12 December 2020

A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin

1 reference

12 December 2020

Pharmacokinetic drug interactions with phenytoin (Part II).

1 reference

12 December 2020

Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects.

1 reference

12 December 2020

Pharmacokinetic drug interactions with phenytoin (Part I).

1 reference

12 December 2020

In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme

1 reference

12 December 2020

Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians

1 reference

12 December 2020

Stereoselective metabolism and pharmacogenetic control of 5-phenyl-5-ethylhydantoin (nirvanol) in humans.

1 reference

12 December 2020

Stereoselective 4'-hydroxylation of phenytoin: relationship to (S)-mephenytoin polymorphism in Japanese

1 reference

12 December 2020

Influence of corticosteroid on hexobarbital and tolbutamide disposition

1 reference

12 December 2020

CYP2C19 genotype status and intragastric pH during dosing with lansoprazole or rabeprazole

1 reference

12 December 2020

Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations

1 reference

12 December 2020

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase

1 reference

12 December 2020

Acute phenytoin toxicity followed by seizure breakthrough from a ticlopidine-phenytoin interaction

1 reference

12 December 2020

The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study

1 reference

12 December 2020

The effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4'-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

CYP2C19 genotypes and omeprazole metabolism after single and repeated dosing when combined with clarithromycin

1 reference

12 December 2020

Comparison of the kinetic disposition and metabolism of E3810, a new proton pump inhibitor, and omeprazole in relation to S-mephenytoin 4'-hydroxylation status

1 reference

12 December 2020

Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia.

1 reference

12 December 2020

Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation

1 reference

12 December 2020

Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin

1 reference

12 December 2020

P-hydroxylation of phenobarbital: relationship to (S)-mephenytoin hydroxylation (CYP2C19) polymorphism

1 reference

12 December 2020

Evaluation of a potential enantioselective interaction between ticlopidine and warfarin in chronically anticoagulated patients.

1 reference

12 December 2020

Enantioselective hydroxylation of omeprazole catalyzed by CYP2C19 in Swedish white subjects

1 reference

12 December 2020

Carbamazepine treatment induces the CYP3A4 catalysed sulphoxidation of omeprazole, but has no or less effect on hydroxylation via CYP2C19.

1 reference

12 December 2020

A SNPshot: pharmacogenetics and the future of drug therapy

1 reference

12 December 2020

Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

Cimetidine-imipramine interaction: case report and comments

1 reference

12 December 2020

Theophylline steady state pharmacokinetics is not altered by omeprazole

1 reference

12 December 2020

Diazepam metabolism in native Chinese poor and extensive hydroxylators of S-mephenytoin: interethnic differences in comparison with white subjects.

1 reference

12 December 2020

The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo.

1 reference

12 December 2020

Diazepam disposition determinants.

1 reference

12 December 2020

Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients

1 reference

12 December 2020

Molecular mechanisms of genetic polymorphisms of drug metabolism

1 reference

12 December 2020

The pharmacology of the gastric acid pump: the H+,K+ ATPase

1 reference

12 December 2020

Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark

1 reference

12 December 2020

Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia

1 reference

12 December 2020

Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests

1 reference

12 December 2020

Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole

1 reference

12 December 2020

Stereoselective disposition of hexobarbital and its metabolites: relationship to the S-mephenytoin polymorphism in Caucasian and Chinese subjects

1 reference

12 December 2020

Polymorphisms in oxidative drug metabolism: relationship to food preference

1 reference

12 December 2020

Genotyping of S-mephenytoin 4'-hydroxylation in an extended Japanese population

1 reference

12 December 2020

Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes

1 reference

12 December 2020

Fluoxetine pharmacokinetics and effect on CYP2C19 in young and elderly volunteers

1 reference

12 December 2020

Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk.

1 reference

12 December 2020

Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19

1 reference

12 December 2020

Effects of ketoconazole on the polymorphic 4-hydroxylations of S-mephenytoin and debrisoquine

1 reference

12 December 2020

Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4.

1 reference

12 December 2020

In vivo modulation of CYP enzymes by quinidine and rifampin

1 reference

12 December 2020

Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians

1 reference

12 December 2020

Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism

1 reference

12 December 2020

Pharmacokinetics of [14C]omeprazole in patients with liver cirrhosis

1 reference

12 December 2020

Effect of ketoconazole on the pharmacokinetics of imipramine and desipramine in healthy subjects

1 reference

12 December 2020

Effects of omeprazole and cimetidine on the urinary metabolic ratio of proguanil in healthy volunteers

1 reference

12 December 2020

Debrisoquin and S-mephenytoin hydroxylation phenotypes and CYP2D6 genotypes in an Estonian population

1 reference

12 December 2020

Effect of CYP2C19 polymorphism on serum levels of vitamin B12 in patients on long-term omeprazole treatment

1 reference

12 December 2020

Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the world

1 reference

12 December 2020

Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation

1 reference

12 December 2020

Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases.

1 reference

12 December 2020

Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer

1 reference

12 December 2020

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1 reference

12 December 2020

Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver microsomes.

1 reference

12 December 2020

Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.

1 reference

12 December 2020

The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening costs and influence on clinical outcomes in psychiatry

1 reference

12 December 2020

Formation of meprobamate from carisoprodol is catalysed by CYP2C19.

1 reference

12 December 2020

Hydroxylation and demethylation of the tricyclic antidepressant nortriptyline by cDNA-expressed human cytochrome P-450 isozymes

1 reference

12 December 2020

Lack of pharmacokinetic interaction of pantoprazole with diazepam in man.

1 reference

12 December 2020

Inhibition of the sulfoxidation of omeprazole by ketoconazole in poor and extensive metabolizers of S-mephenytoin.

1 reference

12 December 2020

Genetic polymorphism of S-mephenytoin hydroxylation

1 reference

12 December 2020

Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark

1 reference

12 December 2020

Cimetidine alters the disposition kinetics of the monoamine oxidase-A inhibitor moclobemide

1 reference

12 December 2020

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction

1 reference

12 December 2020

S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians.

1 reference

12 December 2020

Role of CYP2C19 in stereoselective hydroxylation of mephobarbital by human liver microsomes.

1 reference

12 December 2020

Combination treatment with clomipramine and fluvoxamine: drug monitoring, safety, and tolerability data

1 reference

12 December 2020

Human P450 metabolism of warfarin

1 reference

12 December 2020

Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes

1 reference

12 December 2020

Effects of felbamate on the pharmacokinetics of phenobarbital

1 reference

12 December 2020

Genotype analysis of the CYP2C19 gene in the Japanese population

1 reference

12 December 2020

Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele

1 reference

12 December 2020

Effect of omeprazole and cimetidine on plasma diazepam levels.

1 reference

12 December 2020

Carisoprodol elimination in humans

1 reference

12 December 2020

High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu.

1 reference

12 December 2020

An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians

1 reference

12 December 2020

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

12 December 2020

Metabolic disposition of imipramine in oriental subjects: relation to metoprolol alpha-hydroxylation and S-mephenytoin 4'-hydroxylation phenotypes

1 reference

12 December 2020

Steady-state plasma concentrations of imipramine and desipramine in relation to S-mephenytoin 4'-hydroxylation status in Japanese depressive patients

1 reference

12 December 2020

Use of the nuclear receptor PXR to predict drug interactions

1 reference

12 December 2020

Single-dose kinetics of clomipramine: relationship to the sparteine and S-mephenytoin oxidation polymorphisms

1 reference

12 December 2020

Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4.

1 reference

12 December 2020

Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance

1 reference

12 December 2020

A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin

1 reference

12 December 2020

Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities

1 reference

12 December 2020

CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics

1 reference

12 December 2020

Why are diazepam metabolism and polymorphic S-mephenytoin hydroxylation associated with each other in white and Korean populations but not in Chinese populations?

1 reference

12 December 2020

Determination of R(+)- and S(-)-lansoprazole using chiral stationary-phase liquid chromatography and their enantioselective pharmacokinetics in humans

1 reference

12 December 2020

Identification of the human P450 enzymes involved in lansoprazole metabolism.

1 reference

12 December 2020

Five distinct human cytochromes mediate amitriptyline N-demethylation in vitro: dominance of CYP 2C19 and 3A4

1 reference

12 December 2020

Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition

1 reference

12 December 2020

Interaction of human liver cytochromes P450 in vitro with LY307640, a gastric proton pump inhibitor

1 reference

12 December 2020

Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation

1 reference

12 December 2020

Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians.

1 reference

12 December 2020

Potential pharmacokinetic interaction between felbamate and phenobarbital

1 reference

12 December 2020

In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes

1 reference

12 December 2020

Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers.

1 reference

12 December 2020

Stereoselectivity of differential routes of drug metabolism: the fate of the enantiomers of [14C]mephenytoin in the dog

1 reference

12 December 2020

Diazepam interaction with antituberculosis drugs.

1 reference

12 December 2020

Frequency of S-mephenytoin hydroxylation deficiency in 373 spanish subjects compared to other Caucasian populations

1 reference

12 December 2020

Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6

1 reference

12 December 2020

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese

1 reference

12 December 2020

Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome

1 reference

12 December 2020

Stereoselective metabolism of mephenytoin in man

1 reference

12 December 2020

Analysis of variation in plasma concentrations of nelfinavir and its active metabolite M8 in HIV-positive patients

1 reference

12 December 2020

Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation.

1 reference

12 December 2020

Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations

1 reference

12 December 2020

The CYP2C19 enzyme polymorphism

1 reference

12 December 2020

Omeprazole and CYP2C19 polymorphism: effects of long-term treatment on gastrin, pepsinogen I, and chromogranin A in patients with acid related disorders

1 reference

12 December 2020

Vitamin B12 levels during prolonged treatment with proton pump inhibitors

1 reference

12 December 2020

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

1 reference

12 December 2020

Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro.

1 reference

12 December 2020

Interethnic differences in omeprazole metabolism in the two S-mephenytoin hydroxylation phenotypes studied in Caucasians and Orientals

1 reference

12 December 2020

The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam.

1 reference

12 December 2020

Specific and dose-dependent enzyme induction by omeprazole in human beings.

1 reference

12 December 2020

Mephenytoin hydroxylation deficiency: kinetics after repeated doses

1 reference

12 December 2020

Stereochemistry of aromatic phenytoin hydroxylation in various drug hydroxylation phenotypes in humans

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic interactions between fluoxetine and moclobemide in the investigation of development of the "serotonin syndrome"

1 reference

12 December 2020

Induction of drug metabolising enzymes: pharmacokinetic and toxicological consequences in humans

1 reference

12 December 2020

Cytochrome P450 enzymes: interpretation of their interactions with selective serotonin reuptake inhibitors. Part II.

1 reference

12 December 2020

The pharmacokinetics of omeprazole in humans--a study of single intravenous and oral doses

1 reference

12 December 2020