(Q28203455)

English

The von Hippel-Lindau tumor suppressor gene

scientific article (publication date: 10 March 2001)

In more languages

edit

Statements

0 references

1 reference

Europe PubMed Central

title

The von Hippel-Lindau tumor suppressor gene (English)

0 references

2

W G Kaelin

0 references

author name string

K Kondo

series ordinal

1

0 references

language of work or name

English

0 references

publication date

10 March 2001

0 references

published in

Experimental Cell Research

0 references

volume

264

0 references

page(s)

117-25

0 references

issue

1

0 references

cites work

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

Mutations of the VHL tumour suppressor gene in renal carcinoma

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NG0594-85

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Frequent overexpression of vascular endothelial growth factor gene in human renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Comparative sequence analysis of the VHL tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Genotype-phenotype correlations in von Hippel-Lindau disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

ZUR FRAGE DER ANGIOMATOSIS RETINae UND IHRER HIRNKOMPLIKATIONEN

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Mutation of the Von Hippel-Lindau tumour suppressor gene in capillary haemangioblastomas of the central nervous system

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Differential response to transforming growth factor (TGF)-alpha and fibroblast growth factor (FGF) in human renal cell carcinomas of the clear cell and papillary types

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Inhibition of insulin-like growth factor-I-mediated cell signaling by the von Hippel-Lindau gene product in renal cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Somatic mosaicism in von Hippel-Lindau Disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Hypoxia and human placental development.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Mosaicism in von Hippel-Lindau disease: lessons from kindreds with germline mutations identified in offspring with mosaic parents

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

VHL gene deletion and enhanced VEGF gene expression detected in the stromal cells of retinal angioma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Tumour suppression by the human von Hippel-Lindau gene product

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Polycythemia: mechanisms and management

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Isolation and characterization of the full-length 3' untranslated region of the human von Hippel-Lindau tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Oncogenic alterations of metabolism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

von Hippel-Lindau disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Über eine sehr seltene Erkrankung der Netzhaut

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Germline mutations in the vhl gene in patients presenting with phaeochromocytomas.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Molecular genetic diagnosis of von Hippel-Lindau disease in familial phaeochromocytoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Cell cycle: cull and destroy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Molecular genetic analysis of the von Hippel-Lindau disease tumor suppressor gene in familial and sporadic cerebellar hemangioblastomas

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Inhibition of transcription elongation by the VHL tumor suppressor protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Expression of growth factors and growth factor receptors in capillary hemangioblastoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Lessons from hereditary colorectal cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

SCF and Cullin/Ring H2-based ubiquitin ligases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Germline and somatic mutations in von Hippel-Lindau disease gene and its significance in the development of kidney cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1006/EXCR.2000.5139

Identifiers

DOI

10.1006/EXCR.2000.5139

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

240947

OpenCitations bibliographic resource ID

240947

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

240947

(Q28203455)

The von Hippel-Lindau tumor suppressor gene

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)