(Q28204430)

ChEBI release 2020-05-28

ChEBI ID

34159

cardiovascular disease

1 reference

2

Issei Komuro

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author name string

Hiroyuki Takano

series ordinal

1

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language of work or name

English

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publication date

2002

1 reference

Journal of Diabetes and its Complications

PubMed

published in

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volume

16

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issue

1

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page(s)

108-14

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cites work

Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor-alpha exert synergistic antiproliferative effects on human coronary artery smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor (PPAR)-gamma expression in human vascular smooth muscle cells: inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)-gamma activator troglitazone

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

CREB-binding protein/p300 are transcriptional coactivators of p65

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

PPAR gamma-ligands inhibit migration mediated by multiple chemoattractants in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Control of vascular cell proliferation and migration by PPAR-gamma: a new approach to the macrovascular complications of diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in rat aortic smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor gamma-mediated transcriptional up-regulation of the hepatocyte growth factor gene promoter via a novel composite cis-acting element

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Leptin, peroxisome proliferator-activated receptor-gamma, and CCAAT/enhancer binding protein-alpha mRNA expression in adipose tissue of humans and their relation to cardiovascular risk factors.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

The antidiabetic agent thiazolidinedione stimulates the interaction between PPAR gamma and CBP.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Troglitazone induces apoptosis via the p53 and Gadd45 pathway in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-gamma activators

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Activation of PPARgamma coactivator-1 through transcription factor docking

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Activators of the nuclear receptor PPARgamma enhance colon polyp formation

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Expression of peroxisome proliferator-activated receptor (PPAR)gamma in gastric cancer and inhibitory effects of PPARgamma agonists

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor activators inhibit lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal rat cardiac myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor-gamma activation inhibits interleukin-1beta -mediated platelet-derived growth factor-alpha receptor gene expression via CCAAT/enhancer-binding protein-delta in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Peroxisome proliferator-activated receptor gamma C161-->T polymorphism and coronary artery disease

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021

Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1056-8727%2801%2900203-3

7 January 2021