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Themes and variations on ubiquitylation
scientific article (publication date: March 2001)
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scholarly article
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review article
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Europe PubMed Central
title
Themes and variations on ubiquitylation
(English)
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main subject
ubiquitination
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based on heuristic
inferred from title
author name string
A M Weissman
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1
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language of work or name
English
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publication date
March 2001
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published in
Nature Reviews Molecular Cell Biology
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volume
2
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page(s)
169-78
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issue
3
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cites work
Recognition of the polyubiquitin proteolytic signal
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Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern
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Ubiquitin and its kin: how close are the family ties?
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Ubiquitin-like proteins: new wines in new bottles
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The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome
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A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
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RING finger proteins: mediators of ubiquitin ligase activity
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The tails of ubiquitin precursors are ribosomal proteins whose fusion to ubiquitin facilitates ribosome biogenesis
1 reference
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Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome
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Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent
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Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85
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An essential domain within Cdc34p is required for binding to a complex containing Cdc4p and Cdc53p in Saccharomyces cerevisiae
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The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain
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A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum
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Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha
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Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7
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Pathways of ubiquitin conjugation.
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Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade
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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases
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Identification of determinants in E2 ubiquitin-conjugating enzymes required for hect E3 ubiquitin-protein ligase interaction
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Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution
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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
1 reference
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Crossref
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Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.
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Crossref
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UBE3A/E6-AP mutations cause Angelman syndrome
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7 January 2021
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Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases
1 reference
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Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb
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Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.
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Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation
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Ubiquitin and the control of protein fate in the secretory and endocytic pathways
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A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel
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RING for destruction?
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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
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Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha
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Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
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7 January 2021
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Crossref
reference URL
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7 January 2021
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1 reference
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Crossref
reference URL
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7 January 2021
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1 reference
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Crossref
reference URL
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7 January 2021
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1 reference
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Crossref
reference URL
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7 January 2021
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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7
1 reference
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Crossref
reference URL
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7 January 2021
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Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins
1 reference
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Crossref
reference URL
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7 January 2021
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Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins.
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
The cancer-predisposing mutation C61G disrupts homodimer formation in the NH2-terminal BRCA1 RING finger domain
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
based on heuristic
inferred from DOI database lookup
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The APC11 RING-H2 finger mediates E2-dependent ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SCF and Cullin/Ring H2-based ubiquitin ligases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The anaphase-promoting complex: new subunits and regulators
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
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inferred from DOI database lookup
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1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deubiquitinating enzymes: their diversity and emerging roles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substrate-specific role in protein turnover.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ER protein quality control and proteasome-mediated protein degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a cryptic nucleolar-localization signal in MDM2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MdmX protects p53 from Mdm2-mediated degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2 interacts with MDMX through their RING finger domains
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 binds p73 alpha without targeting degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of the p53-homologue p73 by the mdm2-oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDM2 suppresses p73 function without promoting p73 degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
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Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
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A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
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Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
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A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
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Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
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A novel protein modification pathway related to the ubiquitin system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
retrieved
7 January 2021
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Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
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The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35056563
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7 January 2021
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Identifiers
DOI
10.1038/35056563
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1217634
Dimensions Publication ID
1039124543
0 references
OpenCitations bibliographic resource ID
1217634
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1217634
PubMed ID
11265246
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1217634
ResearchGate publication ID
12068179
0 references
Springer Nature article ID
10.1038/35056563
0 references
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