(Q28208049)

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.

31 March 2020

1 reference

Delivery of molecular and cellular medicine to solid tumors

31 March 2020

1 reference

Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy

31 March 2020

1 reference

Resistance of tumor cells to chemo- and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids

31 March 2020

1 reference

The human ATP-binding cassette (ABC) transporter superfamily

31 March 2020

1 reference

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

31 March 2020

1 reference

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

31 March 2020

1 reference

Ceramide glycosylation potentiates cellular multidrug resistance

31 March 2020

1 reference

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

31 March 2020

1 reference

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

31 March 2020

1 reference

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

31 March 2020

1 reference

P-glycoprotein shows strong catalytic cooperativity between the two nucleotide sites.

31 March 2020

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Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state

31 March 2020

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Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

31 March 2020

1 reference

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

31 March 2020

1 reference

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

31 March 2020

1 reference

A family of drug transporters: the multidrug resistance-associated proteins.

31 March 2020

1 reference

A multidrug resistance transporter from human MCF-7 breast cancer cells

31 March 2020

1 reference

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

31 March 2020

1 reference

Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippase

31 March 2020

1 reference

ABC transporters in lipid transport

31 March 2020

1 reference

Lung resistance-related protein/major vault protein and vaults in multidrug-resistant cancer

31 March 2020

1 reference

MRP3, an organic anion transporter able to transport anti-cancer drugs

31 March 2020

1 reference

MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver

31 March 2020

1 reference

Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine

31 March 2020

1 reference

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

31 March 2020

1 reference

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

31 March 2020

1 reference

The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides

31 March 2020

1 reference

Mutations of the gene encoding the transmembrane transporter protein ABC-C6 cause pseudoxanthoma elasticum

31 March 2020

1 reference

Mutations in ABCC6 cause pseudoxanthoma elasticum

31 March 2020

1 reference

Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter

31 March 2020

1 reference

Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum

31 March 2020

1 reference

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

31 March 2020

1 reference

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

31 March 2020

1 reference

The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.

31 March 2020

1 reference

Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier

31 March 2020

1 reference

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues

31 March 2020

1 reference

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan

31 March 2020

1 reference

Calcium regulates estrogen increase in permeability of cultured CaSki epithelium by eNOS-dependent mechanism

31 March 2020

1 reference

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

31 March 2020

1 reference

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

31 March 2020

1 reference

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

31 March 2020

1 reference

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

31 March 2020

1 reference

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

31 March 2020

1 reference

Phosphatidylcholine translocase: a physiological role for the mdr2 gene

31 March 2020

1 reference

Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis

31 March 2020

1 reference

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833

31 March 2020

1 reference

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

31 March 2020

1 reference

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

31 March 2020

1 reference

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

31 March 2020

1 reference

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells

31 March 2020

1 reference

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

31 March 2020

1 reference

Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats.

31 March 2020

1 reference

Expression of a multidrug-resistance gene in human tumors and tissues

31 March 2020

1 reference

Expression of a multidrug resistance gene in human cancers

31 March 2020

1 reference

Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP).

31 March 2020

1 reference

Expression of functional markers in acute nonlymphoblastic leukemia.

31 March 2020

1 reference

Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia.

31 March 2020

1 reference

P-glycoprotein, lung resistance-related protein and multidrug resistance associated protein in de novo acute non-lymphocytic leukaemias: biological and clinical implications.

31 March 2020

1 reference

P-Glycoprotein inhibitor valspodar (PSC 833) increases the intracellular concentrations of daunorubicin in vivo in patients with P-glycoprotein-positive acute myeloid leukemia

31 March 2020

1 reference

Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance.

31 March 2020

1 reference

In vivo detection of multidrug-resistant (MDR1) phenotype by technetium-99m sestamibi scan in untreated breast cancer patients

31 March 2020

1 reference

Expression of mediated P-glycoprotein multidrug resistance related to Tc-99m MIBI scintimammography results.

31 March 2020

1 reference

The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer

31 March 2020

1 reference

Multidrug-resistant gene expression in small-cell lung cancer

31 March 2020

1 reference

Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer

31 March 2020

1 reference

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood

31 March 2020

1 reference

P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy

31 March 2020

1 reference

Effect of P-glycoprotein expression on outcome in the Ewing family of tumors.

31 March 2020

1 reference

Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome

31 March 2020

1 reference

Incidence of P-glycoprotein overexpression and multidrug resistance (MDR) reversal in adult soft tissue sarcoma.

31 March 2020

1 reference

MDR1 gene expression and outcome in osteosarcoma: a prospective, multicenter study.

31 March 2020

1 reference

P-glycoprotein expression at diagnosis may not be a primary mechanism of therapeutic failure in childhood rhabdomyosarcoma

31 March 2020

1 reference

Clinical trials of P-glycoprotein reversal in solid tumours

31 March 2020

1 reference

Clinical Studies with Modulators of Multidrug Resistance

31 March 2020

1 reference

Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance.

31 March 2020

1 reference

Pharmacological considerations in the modulation of multidrug resistance

31 March 2020

1 reference

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

31 March 2020

1 reference

Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833.

31 March 2020

1 reference

Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia

31 March 2020

1 reference

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia

31 March 2020

1 reference

Parallel phase I studies of daunorubicin given with cytarabine and etoposide with or without the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age or older with acute myeloid leukemia: results of cancer and leuk

31 March 2020

1 reference

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

31 March 2020

1 reference

Modulation of multidrug-resistant multiple myeloma by cyclosporin. The Leukaemia Group of the EORTC and the HOVON

31 March 2020

1 reference

Oral verapamil with chemotherapy for advanced non-small cell lung cancer: a randomised study

31 March 2020

1 reference

Phase I study of paclitaxel in combination with a multidrug resistance modulator, PSC 833 (Valspodar), in refractory malignancies.

31 March 2020

1 reference

Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: a gynecologic oncology group study.

31 March 2020

1 reference

Differential inhibition by cyclosporins of primary-active ATP-dependent transporters in the hepatocyte canalicular membrane

31 March 2020

1 reference

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance

31 March 2020

1 reference

Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance.

31 March 2020

1 reference

Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP.

31 March 2020

1 reference

Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy

31 March 2020

1 reference

Sufficient levels of quinine in the serum circumvent the multidrug resistance of the human leukemic cell line K562/ADM.

31 March 2020

1 reference

Phase I study of intravenous PSC-833 and doxorubicin: reversal of multidrug resistance

31 March 2020

1 reference

Phase I and pharmacokinetic study of the novel MDR1 and MRP1 inhibitor biricodar administered alone and in combination with doxorubicin

31 March 2020

1 reference

99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein

31 March 2020

1 reference

Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin

31 March 2020

1 reference

Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdr1 gene activation by the cyclosporin PSC 833.

31 March 2020

1 reference

Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

31 March 2020

1 reference

Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

31 March 2020

1 reference

Pharmacological characterization of LY335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein

31 March 2020

1 reference

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

31 March 2020

1 reference

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

31 March 2020

1 reference

Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy

31 March 2020

1 reference

Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer

31 March 2020

1 reference

Drug resistance-associated marker Lrp for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma.

31 March 2020

1 reference

Pharmacokinetics of vincristine in cancer patients treated with nifedipine

31 March 2020

1 reference