(Q28208783)

English

Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B

scientific article (publication date: 19 December 2003)

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scholarly article

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Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B (English)

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phosphorylation

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based on heuristic

inferred from title

tuberous sclerosis

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based on heuristic

inferred from title

tuberous sclerosis 1

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based on heuristic

inferred from title

Aristotelis Astrinidis

1

object named as

Aristotelis Astrinidis

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author name string

William Senapedis

2

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Thomas R Coleman

3

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Elizabeth Petri Henske

4

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language of work or name

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publication date

19 December 2003

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Journal of Biological Chemistry

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278

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51372-9

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51

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Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

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https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

The TSC1 gene product, hamartin, negatively regulates cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Tuberous sclerosis gene 2 product modulates transcription mediated by steroid hormone receptor family members.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Growth signaling: TSC takes its place.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Identification and characterization of the interaction between tuberin and 14-3-3zeta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Regulating the onset of mitosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Mitotic kinases as regulators of cell division and its checkpoints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Expression of wild type and mutant TSC2, but not TSC1, causes an increase in the G1 fraction of the cell cycle in HEK293 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Use of an oriented peptide library to determine the optimal substrates of protein kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Cdc2-cyclin B phosphorylates p70 S6 kinase on Ser411 at mitosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303956200

21 January 2018

Identifiers

10.1074/JBC.M303956200

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