(Q28209536)

Breast cancer 2, early onset

GOA release 2020-03-11

1 reference

protein-protein interaction

GOA release 2020-03-11

1 reference

C J Sarkisian

1

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S R Master

2

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L J Huber

3

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S I Ha

4

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L A Chodosh

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

5 October 2001

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published in

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volume

276

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page(s)

37640-8

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issue

40

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cites work

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Identification of the breast cancer susceptibility gene BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

BRCA1 is a cell cycle-regulated nuclear phosphoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

The BRCA2 gene product functionally interacts with p53 and RAD51

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Internal repeats in the BRCA2 protein sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

The BRC repeats are conserved in mammalian BRCA2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Brca2 is required for embryonic cellular proliferation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Involvement of Brca2 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Impaired DNA damage response in cells expressing an exon 11-deleted murine Brca1 variant that localizes to nuclear foci

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Functional domains of the BRCA1 and BRCA2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Nucleocytoplasmic transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

BRCA2 is required for homology-directed repair of chromosomal breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Nuclear localization signals of the BRCA2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200

Multiple possible sites of BRAC2 interacting with DNA repair protein RAD51

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M106281200