(Q28217202)

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Biomimetic synthesis and optimization of cyclic peptide antibiotics

scientific article (publication date: 8 August 2002)

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Biomimetic synthesis and optimization of cyclic peptide antibiotics (English)

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Rahul M Kohli

1

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author name string

Christopher T Walsh

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2

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Michael D Burkart

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3

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language of work or name

English

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publication date

8 August 2002

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published in

Nature

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volume

418

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page(s)

658-61

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issue

6898

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cites work

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Antimicrobial peptides of multicellular organisms

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Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis

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Generality of peptide cyclization catalyzed by isolated thioesterase domains of nonribosomal peptide synthetases.

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Nuclear Overhauser effect and cross-relaxation rate determinations of dihedral and transannular interproton distances in the decapeptide tyrocidine A.

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Innate antimicrobial peptide protects the skin from invasive bacterial infection

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Conversion of serine-114 to cysteine-114 and the role of the active site nucleophile in acyl transfer by myristoyl-ACP thioesterase from Vibrio harveyi

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Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes

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Cationic peptides: a new source of antibiotics

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Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity.

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Structural requirements for the biosynthesis of backbone cyclic peptide libraries.

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Constrained peptides: models of bioactive peptides and protein substructures

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7 January 2021

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Harnessing the biosynthetic code: combinations, permutations, and mutations

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Chain termination steps in nonribosomal peptide synthetase assembly lines: directed acyl-S-enzyme breakdown in antibiotic and siderophore biosynthesis

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A semiautomated hemolysis microassay for membrane lytic proteins

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Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains

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Identifiers

DOI

10.1038/NATURE00907

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Dimensions Publication ID

1014229180

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PubMed ID

12167866

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Springer Nature article ID

10.1038/nature00907

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(Q28217202)

Biomimetic synthesis and optimization of cyclic peptide antibiotics

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