(Q28236671)

Why is big Pharma getting out of antibacterial drug discovery?

31 March 2020

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Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?

31 March 2020

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A scoring scheme for discriminating between drugs and nondrugs.

31 March 2020

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Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry

31 March 2020

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

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Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries

31 March 2020

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Distinguishing between natural products and synthetic molecules by descriptor Shannon entropy analysis and binary QSAR calculations

31 March 2020

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Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds

31 March 2020

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Diverse viewpoints on computational aspects of molecular diversity.

31 March 2020

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Beyond mere diversity: tailoring combinatorial libraries for drug discovery

31 March 2020

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Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

31 March 2020

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One thousand families for the molecular biologist

31 March 2020

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Estimating the number of protein folds.

31 March 2020

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Correlation of observed fold frequency with the occurrence of local structural motifs.

31 March 2020

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Mapping the protein universe

31 March 2020

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A global representation of the protein fold space

31 March 2020

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Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteins

31 March 2020

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From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

31 March 2020

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Combinatorial modification of natural products: preparation of unencoded and encoded libraries of Rauwolfia alkaloids

31 March 2020

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New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Inst

31 March 2020

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Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold

31 March 2020

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Peptide and Protein Recognition by Designed Molecules

31 March 2020

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FK506, an immunosuppressant targeting calcineurin function

31 March 2020

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Immunopharmacology of rapamycin

31 March 2020

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Therapeutic implications for immunophilin ligands in the treatment of neurodegenerative diseases

31 March 2020

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The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

31 March 2020

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Podophyllotoxin, steganacin and combretastatin: natural products that bind at the colchicine site of tubulin

31 March 2020

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New assay technologies for high-throughput screening

31 March 2020

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Protein kinases--the major drug targets of the twenty-first century?

31 March 2020

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Fluorescence assays for high-throughput screening of protein kinases

31 March 2020

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An evaluation of fluorescence polarization and lifetime discriminated polarization for high throughput screening of serine/threonine kinases

31 March 2020

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Evaluation of fluorescent compound interference in 4 fluorescence polarization assays: 2 kinases, 1 protease, and 1 phosphatase

31 March 2020

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High-throughput method for the production and analysis of large natural product libraries for drug discovery

31 March 2020

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Modern methods to produce natural-product libraries

31 March 2020

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Multitarget Affinity/Specificity Screening of Natural Products: Finding and Characterizing High-Affinity Ligands from Complex Mixtures by Using High-Performance Mass Spectrometry

31 March 2020

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Natural products--a simple model to explain chemical diversity

31 March 2020

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Ivermectin, a new broad-spectrum antiparasitic agent.

31 March 2020

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Mannopeptimycins, novel antibacterial glycopeptides from Streptomyces hygroscopicus, LL-AC98.

31 March 2020

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Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria

31 March 2020

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Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

31 March 2020

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Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics.

31 March 2020

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Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria

31 March 2020

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Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography-UV-mass spectrometry methodology.

31 March 2020

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Microflow NMR: concepts and capabilities

31 March 2020

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alpha-Iminocarboxamidato-nickel(II) ethylene polymerization catalysts.

31 March 2020

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FTMS structure elucidation of natural products: application to muraymycin antibiotics using ESI multi-CHEF SORI-CID FTMS(n), the top-down/bottom-up approach, and HPLC ESI capillary-skimmer CID FTMS.

31 March 2020

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Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta

31 March 2020

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Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

31 March 2020

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A generic assay for phosphate-consuming or -releasing enzymes coupled on-line to liquid chromatography for lead finding in natural products

31 March 2020

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Micro-Scale Frontal Affinity Chromatography with Mass Spectrometric Detection: A New Method for the Screening of Compound Libraries

31 March 2020

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Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: applications of a chromatographic biosensor

31 March 2020

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Frontal affinity chromatography combined on-line with mass spectrometry: a tool for the binding study of different epidermal growth factor receptor inhibitors.

31 March 2020

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Liquid chromatography with ultraviolet absorbance-mass spectrometric detection and with nuclear magnetic resonance spectroscopy: a powerful combination for the on-line structural investigation of plant metabolites

31 March 2020

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LC-UV-Solid-Phase Extraction-NMR-MS Combined with a Cryogenic Flow Probe and Its Application to the Identification of Compounds Present in Greek Oregano

31 March 2020

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Liquid chromatography-nuclear magnetic resonance spectroscopy

31 March 2020

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The potential of LC-NMR in phytochemical analysis

31 March 2020

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New Antifungal `Quinone Methide' Diterpenes fromBobgunnia madagascariensis and Study of Their Interconversion by LC/NMR

31 March 2020

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Application of directly coupled HPLC-NMR-MS to the identification and confirmation of quercetin glycosides and phloretin glycosides in apple peel

31 March 2020

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Advancing NMR sensitivity for LC-NMR-MS using a cryoflow probe: application to the analysis of acetaminophen metabolites in urine

31 March 2020

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Online NMR detection of amino acids and peptides in microbore LC

31 March 2020

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Metabolic engineering for drug discovery and development

31 March 2020

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Total synthesis of apoptolidin: construction of enantiomerically pure fragments

31 March 2020

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Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR

31 March 2020

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Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C

31 March 2020

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The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

31 March 2020

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The practical synthesis of a novel and highly potent analogue of bryostatin

31 March 2020

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The 3D-structure of a natural inhibitor of cell adhesion molecule expression

31 March 2020

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Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides

31 March 2020

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Antibody-targeted chemotherapy with immunoconjugates of calicheamicin

31 March 2020

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Gemtuzumab ozogamicin, a potent and selective anti-CD33 antibody-calicheamicin conjugate for treatment of acute myeloid leukemia.

31 March 2020

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A planning strategy for diversity-oriented synthesis

31 March 2020

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Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis

31 March 2020

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Rapid Diversity‐Oriented Synthesis in Microtiter Plates for In Situ Screening of HIV Protease Inhibitors

31 March 2020

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Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

31 March 2020

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Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones

31 March 2020

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High-performance liquid chromatographic-electrospray ionization mass spectrometric analyses for the integration of natural products with modern high-throughput screening

31 March 2020

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