(Q28259261)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

review article

1 reference

title

CDC6: from DNA replication to cell cycle checkpoints and oncogenesis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

Luis R Borlado

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

language of work or name

English

0 references

publication date

28 November 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

page(s)

237-243

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

The DNA damage response during DNA replication

28 December 2019

cites work

1 reference

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21 January 2018

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Flexibility and governance in eukaryotic DNA replication.

21 January 2018

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Cell cycle regulation of DNA replication.

21 January 2018

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Origin recognition and the chromosome cycle

21 January 2018

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Sequential function of gene products relative to DNA synthesis in the yeast cell cycle

21 January 2018

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Cloning and characterization of the Saccharomyces cerevisiae CDC6 gene

21 January 2018

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The fission yeast cdc18+ gene product couples S phase to START and mitosis.

21 January 2018

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A human protein related to yeast Cdc6p

21 January 2018

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DNA replication in the archaea

21 January 2018

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Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.

21 January 2018

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Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.

21 January 2018

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Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells

21 January 2018

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Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae

21 January 2018

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ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

21 January 2018

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Two steps in the assembly of complexes at yeast replication origins in vivo

21 January 2018

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Uninterrupted MCM2-7 function required for DNA replication fork progression

21 January 2018

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An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

21 January 2018

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Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

21 January 2018

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Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs

21 January 2018

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Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants

21 January 2018

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Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.

21 January 2018

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The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association

21 January 2018

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The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem.

21 January 2018

1 reference

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Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.

21 January 2018

1 reference

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The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells

21 January 2018

1 reference

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Analysis of Cdc6 function in the assembly of mammalian prereplication complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Motors and switches: AAA+ machines within the replisome.

21 January 2018

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Opening of the clamp: an intimate view of an ATP-driven biological machine.

21 January 2018

1 reference

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ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

The structure and function of MCM from archaeal M. Thermoautotrophicum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation

21 January 2018

1 reference

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sud1(+) targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast

21 January 2018

1 reference

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Separate SCF(CDC4) recognition elements target Cdc6 for proteolysis in S phase and mitosis.

21 January 2018

1 reference

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Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

21 January 2018

1 reference

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Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

21 January 2018

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Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1

21 January 2018

1 reference

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Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6

21 January 2018

1 reference

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Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase

21 January 2018

1 reference

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Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation.

21 January 2018

1 reference

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Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Mammalian Orc1 protein is selectively released from chromatin and ubiquitinated during the S-to-M transition in the cell division cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Targeted destruction of DNA replication protein Cdc6 by cell death pathways in mammals and yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

A p53-dependent checkpoint pathway prevents rereplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Regulation of CDC6, geminin, and CDT1 in human cells that undergo polyploidization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability--evidence of E2F-1 transcriptional contro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Control of DNA replication and its potential clinical exploitation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

The regulation of INK4/ARF in cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Oncogenic activity of Cdc6 through repression of the INK4/ARF locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

A new mechanism of inactivation of the INK4/ARF locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Deregulation of cyclin E in human cells interferes with prereplication complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Precocious G1/S transitions and genomic instability: the origin connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM268

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGM268

2 references

Consolidated OpenCitations Corpus – April 2017

2836417

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18048387%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

2836417

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

2836417