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NUMB controls p53 tumour suppressor activity
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scholarly article
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title
NUMB controls p53 tumour suppressor activity
(English)
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author
Pier Paolo Di Fiore
series ordinal
8
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Daniela Tosoni
series ordinal
2
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Viviana Galimberti
series ordinal
5
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Paolo Nuciforo
object named as
Paolo Nuciforo
series ordinal
3
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Giuseppe Viale
series ordinal
6
object named as
Giuseppe Viale
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author name string
Ivan N Colaluca
series ordinal
1
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Francesca Senic-Matuglia
series ordinal
4
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Salvatore Pece
series ordinal
7
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language of work or name
English
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publication date
3 January 2008
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published in
Nature
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volume
451
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page(s)
76-80
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issue
7174
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cites work
Asymmetric cell division.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
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inferred from DOI database lookup
Numb is an endocytic protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
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inferred from DOI database lookup
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 mutations in human cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
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inferred from DOI database lookup
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amplification of a gene encoding a p53-associated protein in human sarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor surveillance via the ARF-p53 pathway.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The INK4A/ARF locus and its two gene products
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of genetic and epigenetic processes that influence p14ARF expression in breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Concomitant expression of p16INK4a and p14ARF in primary breast cancer and analysis of inactivation mechanisms.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Mdm2 oncoprotein interacts with the cell fate regulator Numb
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that dynamin-2 functions as a signal-transducing GTPase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of clathrin heavy chain for p53-mediated transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Telomeres, stem cells, senescence, and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the wild-type p53 antioncogene induces guanine nucleotide-dependent stem cell division kinetics
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular mechanisms of coupled monoubiquitination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A Randomized Comparison of Sentinel-Node Biopsy with Routine Axillary Dissection in Breast Cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE06412
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NATURE06412
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4811725
Dimensions Publication ID
1006449989
0 references
OpenCitations bibliographic resource ID
4811725
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4811725
PubMed ID
18172499
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4811725
ResearchGate publication ID
5676499
0 references
Springer Nature article ID
10.1038/nature06412
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