(Q28265682)

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Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application

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scholarly article

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Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application (English)

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Vasilis Vasiliou

10

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author name string

Vindhya Koppaka

1

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David C Thompson

2

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Ying Chen

3

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Manuel Ellermann

4

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Kyriacos C Nicolaou

5

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Risto O Juvonen

6

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Dennis Petersen

7

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Richard A Deitrich

8

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Thomas D Hurley

9

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language of work or name

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publication date

July 2012

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Pharmacological Reviews

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64

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3

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520-39

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Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity

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20 March 2017

Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers

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20 March 2017

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

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20 March 2017

Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase

1 reference

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20 March 2017

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

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20 March 2017

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20 March 2017

Structural and Functional Consequences of Coenzyme Binding to the Inactive Asian Variant of Mitochondrial Aldehyde Dehydrogenase: ROLES OF RESIDUES 475 AND 487

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20 March 2017

Actual Causes of Death in the United States, 2000

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20 March 2017

Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase

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20 March 2017

Structural aspects of aldehyde dehydrogenase that influence dimer-tetramer formation

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20 March 2017

4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal

1 reference

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20 March 2017

Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans

1 reference

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20 March 2017

S-methyl N-butylthiocarbamate sulfoxide: selective carbamoylating agent for mouse mitochondrial aldehyde dehydrogenase

1 reference

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20 March 2017

Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases

1 reference

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20 March 2017

Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes

1 reference

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20 March 2017

Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by chlorpropamide analogues

1 reference

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20 March 2017

Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion

1 reference

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20 March 2017

Poisoning by Coprinus atramentarius

1 reference

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20 March 2017

Inhibition of aldehyde dehydrogenase 2 activity enhances antimycin-induced rat cardiomyocytes apoptosis through activation of MAPK signaling pathway

1 reference

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20 March 2017

Succinic Semialdehyde Dehydrogenase: Biochemical–Molecular–Clinical Disease Mechanisms, Redox Regulation, and Functional Significance

1 reference

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20 March 2017

Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia during development

1 reference

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20 March 2017

Tryptophan in alcoholism treatment I: kynurenine metabolites inhibit the rat liver mitochondrial low Km aldehyde dehydrogenase activity, elevate blood acetaldehyde concentration and induce aversion to alcohol

1 reference

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29 September 2017

Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44⁺ human breast cancer cells

1 reference

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29 September 2017

Metabolism: alcohol, DNA and disease

1 reference

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29 September 2017

ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma

1 reference

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29 September 2017

The aldehyde dehydrogenase enzyme 7A1 is functionally involved in prostate cancer bone metastasis.

1 reference

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29 September 2017

Aldehyde dehydrogenase: its role as a cancer stem cell marker comes down to the specific isoform

1 reference

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29 September 2017

(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.

1 reference

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29 September 2017

Discovery of novel regulators of aldehyde dehydrogenase isoenzymes

1 reference

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29 September 2017

Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Organic Nitrates and Nitrate Tolerance—State of the Art and Future Developments

1 reference

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29 September 2017

A novel dithiocarbamate analogue with potentially decreased ALDH inhibition has copper-dependent proteasome-inhibitory and apoptosis-inducing activity in human breast cancer cells

1 reference

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29 September 2017

Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition

1 reference

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29 September 2017

Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose?

1 reference

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29 September 2017

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth

1 reference

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29 September 2017

Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylase.

1 reference

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29 September 2017

Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Emerging drugs to treat alcoholism

1 reference

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29 September 2017

Mitochondrial aldehyde dehydrogenase and cardiac diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Disulfiram: an old therapeutic with new applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence

1 reference

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29 September 2017

Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

1 reference

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29 September 2017

Antioxidant defenses in the ocular surface.

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29 September 2017

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice

1 reference

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29 September 2017

Deaths: final data for 2006.

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29 September 2017

mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse

1 reference

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29 September 2017

Synergetic bitherapy in mice with xenografts of human prostate cancer using a methional mimic (METLICO) and an aldehyde dehydrogenase 3 inhibitor (MATE): systemic intraperitoneal (IP) and targeted intra-tumoral (IT) administration

1 reference

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29 September 2017

Molecular cloning and oxidative modification of human lens ALDH1A1: implication in impaired detoxification of lipid aldehydes.

1 reference

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29 September 2017

Overcoming drug resistance in hormone- and drug-refractory prostate cancer cell line, PC-3 by docetaxel and gossypol combination.

1 reference

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29 September 2017

Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases

1 reference

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29 September 2017

Preliminary report on clinical trials of antabuse.

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29 September 2017

Aldehyde dehydrogenase inhibitors: alpha,beta-acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture

1 reference

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29 September 2017

Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase.

1 reference

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29 September 2017

The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO

1 reference

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29 September 2017

Heterogeneity of aldehyde dehydrogenase expression in lung cancer cell lines is revealed by Aldefluor flow cytometry-based assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis.

1 reference

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29 September 2017

Explaining the phenomenon of nitrate tolerance

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29 September 2017

Insights into oxazaphosphorine resistance and possible approaches to its circumvention.

1 reference

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29 September 2017

Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family

1 reference

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29 September 2017

Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant

1 reference

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29 September 2017

Anti-dipsotropic isoflavones: the potential therapeutic agents for alcohol dependence

1 reference

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29 September 2017

Critical review of current treatment strategies for advanced hormone insensitive breast cancer.

1 reference

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29 September 2017

Identification of the enzymatic mechanism of nitroglycerin bioactivation

1 reference

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29 September 2017

Determination of in vivo adducts of disulfiram with mitochondrial aldehyde dehydrogenase

1 reference

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29 September 2017

Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism.

1 reference

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29 September 2017

Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3.

1 reference

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29 September 2017

The role of tryptophan in fatigue in different conditions of stress

1 reference

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29 September 2017

Aldehyde dehydrogenase-mediated cellular relative insensitivity to the oxazaphosphorines

1 reference

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29 September 2017

Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity

1 reference

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29 September 2017

Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Identification of a carboxylesterase as the major protein bound by molinate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Human aldehyde dehydrogenase gene family.

1 reference

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29 September 2017

Daidzin and daidzein suppress free-choice ethanol intake by Syrian golden hamsters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Hepatic and metabolic effects of ethanol: pathogenesis and prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde dehydrogenase as probed by site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Daidzin suppresses ethanol consumption by Syrian golden hamsters without blocking acetaldehyde metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

The metabolism of fungicides

1 reference

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29 September 2017

Polymorphism of aldehyde dehydrogenase and alcohol sensitivity

1 reference

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29 September 2017

On the Disulfiram-Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

1 reference

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29 September 2017

Impairment of hepatic microsomal and plasma esterases of the rat by disulfiram and diethyldithiocarbamate

1 reference

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29 September 2017

The effect of disulfiram on the aldehyde dehydrogenases of sheep liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

29 September 2017

Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Focus on molecules: ALDH1A1: from lens and corneal crystallin to stem cell marker.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Doubt about an essential role for constitutive nitric oxide synthase in nitroglycerin-mediated vasodilation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Differences in the roles of conserved glutamic acid residues in the active site of human class 3 and class 2 aldehyde dehydrogenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Comparison of human and rat metabolism of molinate in liver microsomes and slices.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Aldehyde dehydrogenase of mice inhibited by thiocarbamate herbicides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Effects of pH on horse liver aldehyde dehydrogenase: alterations in metal ion activation, number of functioning active sites, and hydrolysis of the acyl intermediate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Inhibition of mouse cytosolic aldehyde dehydrogenase by 4-(diethylamino)benzaldehyde

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Identification of 10-formyltetrahydrofolate dehydrogenase-hydrolase as a major folate binding protein in liver cytosol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

In vivo antitumor activity of 4-amino 4-methyl 2-pentyne 1-al, an inhibitor of aldehyde dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

N,O-diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by s-methyl N, N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Retinal Oxidation Activity and Biological Role of Human Cytosolic Aldehyde Dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Inhibition of aldehyde dehydrogenase by propiolaldehyde, a possible metabolite of pargyline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Effects on rat liver acetaldehyde dehydrogenases in vitro and in vivo by coprine, the disulfiram-like constituent of Coprinus atramentarius

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Preferential inhibition of the low Km aldehyde dehydrogenase activity by pargyline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

2 June 2018

Opioid antagonists for alcohol dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Nitrate reductase activity of mitochondrial aldehyde dehydrogenase (ALDH-2) as a redox sensor for cardiovascular oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Substrate specificity of human and yeast aldehyde dehydrogenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Retinoic acid in development: towards an integrated view

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Overexpression of stem cell associated ALDH1A1, a target of the leukemogenic transcription factor TLX1/HOX11, inhibits lymphopoiesis and promotes myelopoiesis in murine hematopoietic progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Nitrate-based vasodilators inhibit multiple vascular aldehyde dehydrogenases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Aldehyde dehydrogenase gene superfamily: the 2002 update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Subchronic toxicity of chloral hydrate on rats: a drinking water study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

N-hydroxybenzenecarboximidic acid derivatives: a new class of nitroxyl-generating prodrugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

The effect of a novel irreversible inhibitor of aldehyde dehydrogenases 1 and 3 on tumour cell growth and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

In vivo inhibition of aldehyde dehydrogenase by disulfiram

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Inhibition of recombinant human mitochondrial aldehyde dehydrogenase by two intermediate metabolites of disulfiram

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Effect of 4-(diethylamino)benzaldehyde on ethanol metabolism in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Inhibition of rat liver aldehyde dehydrogenase by carbon tetrachloride

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Role of aldehyde dehydrogenase in the biological activity of spermine dialdehyde, a novel immunosuppressive/purging agent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400832

27 November 2018

Development of aldehyde dehydrogenase and alcohol dehydrogenase in mouse eye: evidence for light-induced changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activity of class I, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of human aldehyde dehydrogenase by isosorbide dinitrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of rat liver low Km aldehyde dehydrogenase by thiocarbamate herbicides. Occupational implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prodrugs of Nitroxyl as Potential Aldehyde Dehydrogenase Inhibitors vis-a-vis Vascular Smooth Muscle Relaxants

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blockade of the initiation of murine odontogenesis in vitro by citral, an inhibitor of endogenous retinoic acid synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitrate esters as inhibitors and substrates of aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Citral, an Inhibitor of Retinoic Acid Synthesis, Modifies Chick Limb Development

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

S-methyl-N,N-diethylthiocarbamate sulfoxide and S-methyl-N,N-diethylthiocarbamate sulfone, two candidates for the active metabolite of disulfiram

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of a class 3 aldehyde dehydrogenase at 2.6 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human class 3 aldehyde dehydrogenase, and sensitization of tumor cells that express significant amounts of this enzyme to oxazaphosphorines, by the naturally occurring compound gossypol

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential roles of the conserved amino acids in human liver mitochondrial aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of glutamate 399 and lysine 192 in the mechanism of human liver mitochondrial aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldehyde dehydrogenase catalytic mechanism. A proposal

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyanide is a product of the catalase-mediated oxidation of the alcohol deterrent agent, cyanamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for nitroxyl in the catalase-mediated bioactivation of the alcohol deterrent agent cyanamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism of 3,7-dimethyl-2,6-octadienal (citral) in rat hepatic mitochondrial and cytosolic fractions. Interactions with aldehyde and alcohol dehydrogenases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antabuse (disulfiram) as an affordable and promising anticancer drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood pressure response to ethanol in relation to acetaldehyde levels and dopamine-beta-hydroxylase activity in rats pretreated with disulfiram, cyanamide and coprine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microsomal N-depropargylation of pargyline to propiolaldehyde, an irreversible inhibitor of mitochondrial aldehyde dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies in vitro on the inactivation of mitochondrial rat-liver aldehyde dehydrogenase by the alcohol-sensitizing compounds cyanamide, 1-aminocyclopropanol and disulfiram

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the mechanisms of the esterase and dehydrogenase activities of the cytoplasmic aldehyde dehydrogenase from sheep liver. An alternative view

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of magnesium and calcium on mitochondrial and cytosolic liver aldehyde dehydrogenases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol-cephalosporin antibiotic interactions: an animal model for the detection of disulfiram (Antabuse)-like effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human aldehyde dehydrogenase isozymes by propiolaldehyde

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro inhibition by gossypol of oxidoreductases from human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of 5,5'-dithiobis(1-methyltetrazole) on cytoplasmic aldehyde dehydrogenase and its implications for cephalosporin-alcohol reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-Gossypol reduces invasiveness in metastatic prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of inhibition of aldehyde dehydrogenase by citral, a retinoid antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of cyanamide and disulfiram in effects on liver function

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical effects of chloral hydrate on male rats following 7-day drinking water exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fanconi anemia: adult head and neck cancer and hematopoietic mosaicism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22544865

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/PR.111.005538

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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