(Q28283023)

English

Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression

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scholarly article

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Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression (English)

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phosphorylation

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author name string

Rong Rong

1

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Ezequiel I Surace

2

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Carrie A Haipek

3

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David H Gutmann

4

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Keqiang Ye

5

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language of work or name

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publication date

4 November 2004

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23

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8447-54

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52

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Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

21 January 2018

Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

21 January 2018

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

21 January 2018

Ezrin NH2-terminal domain inhibits the cell extension activity of the COOH-terminal domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

21 January 2018

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

21 January 2018

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

21 January 2018

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

21 January 2018

p21-activated kinase links Rac/Cdc42 signaling to merlin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

21 January 2018

Pak to the future

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Defects in neurofibromatosis 2 protein function can arise at multiple levels.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional analysis of neurofibromatosis 2 (NF2) missense mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

A clue to the therapy of neurofibromatosis type 2: NF2/merlin is a PAK1 inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Three determinants in ezrin are responsible for cell extension activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of the merlin-I product of the neurofibromatosis type 2 tumour suppressor gene to a novel site in beta-fodrin is regulated by association between merlin domains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Interdomain binding mediates tumor growth suppression by the NF2 gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Merlin differentially associates with the microtubule and actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207794

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1207794

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Springer Nature article ID

10.1038/sj.onc.1207794

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