(Q28296898)

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Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours

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Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours (English)

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author name string

Eva Maria Kohler

1

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Shree Harsha Vijaya Chandra

2

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Jürgen Behrens

3

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Jean Schneikert

4

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language of work or name

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publication date

15 January 2009

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Human Molecular Genetics

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18

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2

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213-26

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Identification and characterization of the familial adenomatous polyposis coli gene

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Wnt signaling and gastrointestinal tumorigenesis in mouse models

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Wnt signalling in the mouse intestine

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Wnt/beta-catenin signaling in cancer stemness and malignant behavior

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

WNT signaling in the normal intestine and colorectal cancer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Wnt/beta-catenin signaling in development and disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

beta-catenin destruction complex: insights and questions from a structural perspective

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Association of the APC gene product with beta-catenin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Colorectal cancer and genetic alterations in the Wnt pathway

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

The many ways of Wnt in cancer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Difference in characteristics of APC mutations between colonic and extracolonic tumors of FAP patients: variations with phenotype.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

The in vivo rate of somatic adenomatous polyposis coli mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Wnt signalling and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Redefining the subcellular location and transport of APC: new insights using a panel of antibodies.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Novel self-association of the APC molecule affects APC clusters and cell migration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDN338

21 January 2018

Identifiers

10.1093/HMG/DDN338

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