(Q28300764)

English

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice (English)

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Alzheimer's disease

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author name string

M Citron

1

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D Westaway

2

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W Xia

3

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G Carlson

4

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T Diehl

5

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G Levesque

6

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K Johnson-Wood

7

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M Lee

8

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P Seubert

9

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A Davis

10

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D Kholodenko

11

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R Motter

12

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R Sherrington

13

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B Perry

14

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H Yao

15

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R Strome

16

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I Lieberburg

17

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J Rommens

18

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S Kim

19

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D Schenk

20

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P Fraser

21

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P St George Hyslop

22

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D J Selkoe

23

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language of work or name

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publication date

January 1997

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Nature Medicine

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3

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67-72

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1

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https://scigraph.springernature.com/pub.10.1038/nm0197-67

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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https://api.crossref.org/works/10.1038/NM0197-67

21 April 2017

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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https://api.crossref.org/works/10.1038/NM0197-67

21 April 2017

Amyloid beta-protein and the genetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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New clues to Alzheimer's disease: unraveling the roles of amyloid and tau.

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Generation of amyloid beta protein from its precursor is sequence specific

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https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

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Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

inferred from DOI database lookup

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Chimeric prion protein expression in cultured cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

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Developmental expression of the prion protein gene in glial cells.

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins.

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

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Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

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Comparing the polarities of the amino acids: side-chain distribution coefficients between the vapor phase, cyclohexane, 1-octanol, and neutral aqueous solution

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

inferred from DOI database lookup

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1038%2FNM0197-67

7 January 2021

based on heuristic

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Identifiers

10.1038/NM0197-67

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Consolidated OpenCitations Corpus – April 2017

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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