(Q28302887)

1

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Thurl E Harris

2

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Richard A Roth

3

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John C Lawrence

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

6 July 2007

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published in

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volume

282

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page(s)

20036-44

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issue

27

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cites work

TOR signaling in growth and metabolism

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

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Identification of a conserved motif required for mTOR signaling

21 January 2018

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TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

21 January 2018

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

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Molecular organization of target of rapamycin complex 2.

21 January 2018

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Drosophila target of rapamycin kinase functions as a multimer.

21 January 2018

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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1

21 January 2018

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

21 January 2018

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

21 January 2018

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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Tsc2 is not a critical target of Akt during normal Drosophila development

21 January 2018

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Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

21 January 2018

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Farnesylthiosalicylic acid inhibits mammalian target of rapamycin (mTOR) activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex

21 January 2018

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Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

21 January 2018

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Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

21 January 2018

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Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor

21 January 2018

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

21 January 2018

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Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

21 January 2018

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702376200

mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M702376200

1 reference

Consolidated OpenCitations Corpus – April 2017

93649

93649

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference