(Q28364720)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11717429%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

title

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase (English)

1 reference

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3 December 2019

3

1 reference

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3 December 2019

author name string

B L Bennett

1

1 reference

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3 December 2019

D T Sasaki

2

1 reference

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3 December 2019

E C O'Leary

4

1 reference

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3 December 2019

S T Sakata

5

1 reference

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3 December 2019

W Xu

6

1 reference

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3 December 2019

J C Leisten

7

1 reference

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3 December 2019

A Motiwala

8

1 reference

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3 December 2019

S Pierce

9

1 reference

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3 December 2019

Y Satoh

10

1 reference

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3 December 2019

S S Bhagwat

11

1 reference

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3 December 2019

A M Manning

12

1 reference

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3 December 2019

D W Anderson

13

1 reference

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3 December 2019

language of work or name

English

0 references

publication date

1 November 2001

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

3 December 2019

published in

1 reference

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3 December 2019

volume

98

1 reference

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3 December 2019

page(s)

13681-13686

1 reference

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3 December 2019

issue

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11717429%20AND%20SRC:MED&resulttype=core&format=json

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

3 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

NF-kappaB and AP-1 activation by nitric oxide attenuated apoptotic cell death in RAW 264.7 macrophages

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13)

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Selective interaction of JNK protein kinase isoforms with transcription factors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Avian sarcoma virus 17 carries the jun oncogene

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

The regulation of AP-1 activity by mitogen-activated protein kinases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Developmental expression in the mouse nervous system of the p493F12 SAP kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

An AP1 binding site upstream of the kappa immunoglobulin intron enhancer binds inducible factors and contributes to expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

c-myc, c-fos, and c-jun regulation in the regenerating livers of normal and H-2K/c-myc transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Analysis of the AP-1 sites in the IL-2 promoter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

6 Statistical analysis of enzyme kinetic data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Analysis of pharmacologic inhibitors of Jun N-terminal kinases.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Transcriptional regulation in the immune system: all roads lead to AP-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Oncogene jun encodes a sequence-specific trans-activator similar to AP-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Use of antisense oligomers to study the role of c-jun in G1 progression

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=61101

Defective T Cell Differentiation in the Absence of Jnk1

27 November 2018

1 reference

12 December 2020

Characteristics of the interaction of anthrapyrazole anticancer agents with deoxyribonucleic acids: structural requirements for DNA binding, intercalation, and photosensitization

1 reference

12 December 2020

Activation of Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Tumor Necrosis Factor α Leads to Intercellular Adhesion Molecule-1 Expression

1 reference

12 December 2020

Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias

1 reference

12 December 2020

Erratum [McMahon G, Sun L, Liang C, Tang C: Protein kinase inhibitors: structural determinants for target specificity. Current Opin Drug Discovery Dev (1998) 1(2):131-146. Correction to the structure of Compound 74 (SU-5874) in Figure 9]

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.251194298

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11717429%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

ADS bibcode

2001PNAS...9813681B

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11717429%20AND%20SRC:MED&resulttype=core&format=json

3 December 2019

2 references