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(Q28381821)
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FLT3 TKD MUTATION
genetic variant
TKD MUTATION
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Statements
instance of
Nonsynonymous Variant
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/56
chromosome
human chromosome 13
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/56
genomic start
28592642
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/56
genomic end
28592642
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/56
biological variant of
FLT3
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/56
positive therapeutic predictor for
midostaurin
medical condition treated
acute myeloid leukemia
determination method
CIViC evidence level B
rating
CIViC 3-star trust rating
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/1295
stated in
Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3.
negative therapeutic predictor for
sorafenib
determination method
CIViC evidence level B
rating
CIViC 4-star trust rating
medical condition treated
acute myeloid leukemia
2 references
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/247
stated in
Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/248
stated in
Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia
positive diagnostic predictor for
acute myeloid leukemia
determination method
CIViC evidence level B
rating
CIViC 3-star trust rating
statement disputed by
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/214
stated in
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
positive prognostic predictor for
acute myeloid leukemia
determination method
CIViC evidence level B
rating
CIViC 3-star trust rating
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/171
stated in
Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients
negative prognostic predictor for
acute myeloid leukemia
determination method
CIViC evidence level B
rating
CIViC 4-star trust rating
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/373
stated in
FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications
Identifiers
CIViC variant ID
56
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/56
dbSNP Reference SNP number
rs121913488
1 reference
stated in
CIViC database
HGVS nomenclature
NC_000013.10:g.28592642C>A
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/56
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