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PI3K/PTEN signaling in angiogenesis and tumorigenesis
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scholarly article
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review article
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Europe PubMed Central
title
PI3K/PTEN signaling in angiogenesis and tumorigenesis
(English)
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main subject
angiogenesis
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based on heuristic
inferred from title
author
Ling-Zhi Liu
object named as
Ling-Zhi Liu
series ordinal
2
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Bing-Hua Jiang
object named as
Bing-Hua Jiang
series ordinal
1
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language of work or name
English
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publication date
2009
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published in
Advances in Cancer Research
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volume
102
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page(s)
19-65
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cites work
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29 September 2017
Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: results of a phase II study
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29 September 2017
PTEN acetylation modulates its interaction with PDZ domain
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29 September 2017
Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression
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29 September 2017
Class 1A PI3K regulates vessel integrity during development and tumorigenesis
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29 September 2017
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
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29 September 2017
Tumor microenvironment and angiogenesis
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29 September 2017
H-ras regulates angiogenesis and vascular permeability by activation of distinct downstream effectors
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29 September 2017
Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome
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29 September 2017
Tenets of PTEN tumor suppression
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29 September 2017
Depletion of the cap-associated isoform of translation factor eIF4G induces germline apoptosis in C. elegans
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29 September 2017
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29 September 2017
NF-kappaB and cancer-identifying targets and mechanisms
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29 September 2017
Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
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29 September 2017
ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress
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29 September 2017
Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery
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29 September 2017
Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development
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29 September 2017
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a).
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29 September 2017
Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease
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29 September 2017
The VHL tumor suppressor and HIF: insights from genetic studies in mice
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29 September 2017
The nuclear affairs of PTEN.
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29 September 2017
Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells
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29 September 2017
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
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29 September 2017
Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma.
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29 September 2017
The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: results of a phase I study with pharmacokinetics.
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29 September 2017
New insights into PTEN.
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29 September 2017
A randomized, phase II trial of two dose levels of temsirolimus (CCI-779) in patients with extensive-stage small-cell lung cancer who have responding or stable disease after induction chemotherapy: a trial of the Eastern Cooperative Oncology Group (
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29 September 2017
PI3K/PTEN signaling in tumorigenesis and angiogenesis
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29 September 2017
Phosphatidylinositol 3-kinase in breast cancer: where from here?
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29 September 2017
Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells
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29 September 2017
Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion
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29 September 2017
Akt-mediated activation of HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione
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29 September 2017
Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival
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29 September 2017
Akt1 governs breast cancer progression in vivo
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29 September 2017
A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway
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29 September 2017
The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.
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29 September 2017
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway
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29 September 2017
The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
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29 September 2017
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.
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29 September 2017
A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas
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29 September 2017
The redox regulation of PI 3-kinase-dependent signaling
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29 September 2017
Akt2 regulates cardiac metabolism and cardiomyocyte survival
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29 September 2017
Intracellular signaling in tumor and endothelial cells: The expected and, yet again, the unexpected
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29 September 2017
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
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29 September 2017
c-Jun promotes cellular survival by suppression of PTEN.
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29 September 2017
Regulation of the PTEN phosphatase
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29 September 2017
Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor
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29 September 2017
Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.
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29 September 2017
Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma
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29 September 2017
Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway
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29 September 2017
The role of VEGF receptors in angiogenesis; complex partnerships
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29 September 2017
The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.
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29 September 2017
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
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29 September 2017
Cancer-specific mutations in PIK3CA are oncogenic in vivo
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29 September 2017
Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endotheli
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29 September 2017
Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo
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29 September 2017
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins
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29 September 2017
Phosphatidylinositol 3-kinase mediates angiogenesis and vascular permeability associated with ovarian carcinoma
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29 September 2017
Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
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29 September 2017
Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy
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29 September 2017
Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects
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29 September 2017
Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor
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29 September 2017
Angiopoietin 1 is mitogenic for cultured endothelial cells
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29 September 2017
CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium
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29 September 2017
Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts.
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29 September 2017
Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells
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29 September 2017
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29 September 2017
Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
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29 September 2017
Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
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29 September 2017
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
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29 September 2017
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29 September 2017
Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement
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29 September 2017
Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.
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29 September 2017
Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice
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29 September 2017
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling
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29 September 2017
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
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29 September 2017
Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase
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29 September 2017
Nitric oxide mediates ultrasound-induced hypoxia-inducible factor-1alpha activation and vascular endothelial growth factor-A expression in human osteoblasts
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29 September 2017
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
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29 September 2017
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
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29 September 2017
Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels.
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29 September 2017
COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity
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29 September 2017
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
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29 September 2017
Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways
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29 September 2017
Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization
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29 September 2017
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
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29 September 2017
Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes.
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29 September 2017
Role of MAP kinase in tumor progression and invasion
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29 September 2017
Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide
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29 September 2017
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.
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29 September 2017
Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes
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29 September 2017
PKB binding proteins. Getting in on the Akt.
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29 September 2017
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.
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29 September 2017
Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).
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29 September 2017
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection
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29 September 2017
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
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29 September 2017
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.
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29 September 2017
Tie receptors: new modulators of angiogenic and lymphangiogenic responses
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29 September 2017
Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation
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29 September 2017
PTEN controls tumor-induced angiogenesis
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29 September 2017
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
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29 September 2017
Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways
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29 September 2017
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
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29 September 2017
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.
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29 September 2017
Requirement for phosphatidylinositol-3'-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse
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29 September 2017
The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.
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29 September 2017
Phosphoinositide 3-kinases: a conserved family of signal transducers
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
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29 September 2017
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
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29 September 2017
Phosphatidylinositol 3' kinase: one of the effectors of Ras.
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29 September 2017
Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
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29 September 2017
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol
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29 September 2017
Direct analysis of the binding of Src-homology 2 domains of phospholipase C to the activated epidermal growth factor receptor
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
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29 September 2017
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
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29 September 2017
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
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PubMed Central
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29 September 2017
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.
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2 June 2018
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
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2 June 2018
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
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2 June 2018
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.
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2 June 2018
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
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2 June 2018
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
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2 June 2018
Production of matrix metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha/NF-kappaB pathway
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2 June 2018
Loss of active MEK1-ERK1/2 restores epithelial phenotype and morphogenesis in transdifferentiated MDCK cells
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2 June 2018
Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit
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2 June 2018
Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.
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2 June 2018
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.
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2 June 2018
Mechanisms and consequences of activation of protein kinase B/Akt
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2 June 2018
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.
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2 June 2018
Using structure to define the function of phosphoinositide 3-kinase family members
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2 June 2018
Germline mutations in PTEN are present in Bannayan-Zonana syndrome.
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2 June 2018
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
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2 June 2018
Endothelial p70 S6 kinase 1 in regulating tumor angiogenesis.
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27 November 2018
Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
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27 November 2018
Mast cells can mediate vascular permeability through regulation of the PI3K-HIF-1alpha-VEGF axis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
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27 November 2018
SDF-1alpha/CXCR4 decreases endothelial progenitor cells apoptosis under serum deprivation by PI3K/Akt/eNOS pathway.
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27 November 2018
Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1alpha.
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27 November 2018
Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.
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27 November 2018
Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer.
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27 November 2018
The AKT inhibitor perifosine in biochemically recurrent prostate cancer: a phase II California/Pittsburgh cancer consortium trial.
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27 November 2018
Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies.
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27 November 2018
Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine.
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27 November 2018
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment.
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27 November 2018
Evaluation of antileukaemic effects of rapamycin in patients with imatinib-resistant chronic myeloid leukaemia.
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27 November 2018
Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling.
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27 November 2018
Phase I study of everolimus in pediatric patients with refractory solid tumors.
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27 November 2018
Fatal Epstein-Barr virus-associated lymphoproliferative disorder following treatment with a novel mTOR inhibitor for relapsed chronic lymphocytic leukemia leukemia cells
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27 November 2018
Phase 1 trial of everolimus and gefitinib in patients with advanced nonsmall-cell lung cancer.
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27 November 2018
A Phase 2 study of perifosine in advanced or metastatic breast cancer.
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27 November 2018
Role of PTEN/PI3K pathway in endothelial cells.
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27 November 2018
Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma.
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27 November 2018
A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer.
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27 November 2018
Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.
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27 November 2018
A downstream kinase of the mammalian target of rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability.
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27 November 2018
A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer.
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27 November 2018
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.
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27 November 2018
C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1.
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retrieved
27 November 2018
A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Pten constrains centroacinar cell expansion and malignant transformation in the pancreas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
A phase II study of perifosine in androgen independent prostate cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Detection of gene amplification and deletion in high-grade gliomas using a genome DNA microarray (GenoSensor Array 300).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Phase I and pharmacokinetic study of CCI-779, a novel cytostatic cell-cycle inhibitor, in combination with 5-fluorouracil and leucovorin in patients with advanced solid tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Structural insights into phosphoinositide 3-kinase catalysis and signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2933405
retrieved
27 November 2018
The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation of the PIK3CA gene in ovarian and breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Adaptor Protein Gab1 Couples the Stimulation of Vascular Endothelial Growth Factor Receptor-2 to the Activation of Phosphoinositide 3-Kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JNK and PI3K differentially regulate MMP-2 and MT1-MMP mRNA and protein in response to actin cytoskeleton reorganization in endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3'-Kinase/Akt signal transduction pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase II trial of perifosine in locally advanced, unresectable, or metastatic pancreatic adenocarcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I/II Trial of Temsirolimus Combined With Interferon Alfa for Advanced Renal Cell Carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I Trial of Sirolimus Combined with Radiation and Cisplatin in Non-small Cell Lung Cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-alcoholic steatohepatitis and hepatocellular carcinoma: lessons from hepatocyte-specific phosphatase and tensin homolog (PTEN)-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902002-8
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19595306
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mutation of the PTEN gene in advanced cervical cancer correlated with tumor progression and poor outcome after radiotherapy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19595306
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19595306
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/S0065-230X(09)02002-8
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2963919
OpenCitations bibliographic resource ID
2963919
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2963919
PMCID
2933405
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2963919
PubMed ID
19595306
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2963919
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