(Q28477118)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

2

1 reference

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13 February 2020

author name string

Ryan E Pavlovicz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Andrew B Bonnell

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

R Thomas Boyd

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Dennis B McKay

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Chenglong Li

6

1 reference

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13 February 2020

language of work or name

English

0 references

publication date

15 September 2011

1 reference

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13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

6

1 reference

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13 February 2020

issue

9

1 reference

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13 February 2020

page(s)

e24949

1 reference

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Creative Commons Attribution 4.0 International

13 February 2020

copyright license

start time

15 September 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

19 March 2017

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19 March 2017

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Nicotine binding to brain receptors requires a strong cation-pi interaction

19 March 2017

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19 March 2017

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Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

19 March 2017

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19 March 2017

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Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

19 March 2017

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Refined structure of the nicotinic acetylcholine receptor at 4A resolution

19 March 2017

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UCSF Chimera--a visualization system for exploratory research and analysis

19 March 2017

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Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

19 March 2017

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Protein secondary structure prediction based on position-specific scoring matrices

19 March 2017

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Nicotinic acetylcholine involvement in cognitive function in animals

19 March 2017

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Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes

19 March 2017

1 reference

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Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits

19 March 2017

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Comparative protein modelling by satisfaction of spatial restraints

19 March 2017

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Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization

19 March 2017

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Prediction of protein secondary structure at better than 70% accuracy

19 March 2017

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A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

7 April 2017

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A semiempirical free energy force field with charge-based desolvation

7 April 2017

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7 April 2017

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Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

7 April 2017

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Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors

7 April 2017

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Treating the cognitive deficits of schizophrenia with alpha4beta2 neuronal nicotinic receptor agonists

29 September 2017

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Nicotinic receptor channelopathies and epilepsy

29 September 2017

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Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

29 September 2017

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Structural and functional diversity of native brain neuronal nicotinic receptors

29 September 2017

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Detection and trapping of intermediate states priming nicotinic receptor channel opening

29 September 2017

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Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models

29 September 2017

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A virtual screening study of the acetylcholine binding protein using a relaxed-complex approach

29 September 2017

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In silico models for the human alpha4beta2 nicotinic acetylcholine receptor

29 September 2017

1 reference

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Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding

29 September 2017

1 reference

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Modeling subtype-selective agonists binding with alpha4beta2 and alpha7 nicotinic acetylcholine receptors: effects of local binding and long-range electrostatic interactions

29 September 2017

1 reference

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Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors

29 September 2017

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Brain nicotinic acetylcholine receptors: native subtypes and their relevance.

29 September 2017

1 reference

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Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Cellular mechanisms of nicotine addiction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Characterization of the recombinant human neuronal nicotinic acetylcholine receptors alpha3beta2 and alpha4beta2 stably expressed in HEK293 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Acetylcholine nicotinic receptors: finding the putative binding site of allosteric modulators using the "blind docking" approach

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3174232

The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024949

Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024949

Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics Poisson-Boltzmann surface area approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024949

Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024949

Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0024949

10.1371/JOURNAL.PONE.0024949

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

21949802

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21949802%20AND%20SRC:MED&resulttype=core&format=json