(Q28483069)

D-ribofuranose 5-phosphate

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1-linoleoyl-sn-glycero-3-phosphocholine

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N-(11Z,14Z)-eicosadienoylethanolamine

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1-palmitoyl-2-arachidonoyl-sn-glycerol

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N,N-dimethylsphingosine

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6-guanidinohexanoic acid

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4-acetamidobutyric acid

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(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylic acid

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N-(15Z)-tetracosenoylsphingosine

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gamma-L-glutamylputrescine

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N(6),N(6)-dimethyl-L-lysine

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1-hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine

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N-[(13Z)-docosenoyl]sphingosine

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(RS)-pyroglutamic acid

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1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphoethanolamine

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S-adenosyl-L-homocysteine

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4-guanidinobutyric acid

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phosphorylethanolamine

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N,N-dimethylglycine zwitterion

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glutamate-5-semialdehyde

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N-acetylneuraminic acid

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adenosine monophosphate

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3-hydroxybenzenepropanoic acid

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7alpha-hydroxycholest-4-en-3-one

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PC(16:0/20:4(5Z,8Z,11Z,14Z))

colfosceril palmitate

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2-Methoxy-5Z-hexadecenoic acid

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N(2)-succinyl-L-ornithine

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2-oxobut-3-enoic acid

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PE(18:1(11Z)/22:2(13Z,16Z))

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4-hydroxy-1-pyrroline-2-carboxylic acid

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(R)-3-hydroxybutyric acid

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1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-D-myo-inositol

1 reference

1 reference

1 reference

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1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine

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1,2-dioleoyl-sn-glycero-3-phospho-(1'-sn-glycerol)

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(5S)-5-(carboxymethyl)-L-proline

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6-acetamido-3-aminohexanoic acid

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N-(octadecanoyl)-tetradecasphing-4-enine-1-phosphoethanolamine

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1-meadoyl-sn-glycero-3-phosphocholine

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1-methyl-5-imidazoleacetic acid

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21-hydroxyhenicosanoic acid

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1-hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphocholine

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PC(14:0/18:3(9Z,12Z,15Z))

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1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol

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1-tetradecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine

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(3S)-3-methyl-2-oxo-pentanoic acid

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sn-glycero-3-phosphocholine

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S-adenosyl-L-methionine

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oleoyl-lysophosphatidylcholine

O-acetyl-L-homoserine

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N-acetyl-L-2-aminoadipic acid

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PE(18:0/20:4(5Z,8Z,11Z,14Z))

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(R)-2-hydroxyglutaric acid

(R)-glyceryl 1-phosphate

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(2S)-2-isopropyl-3-oxosuccinic acid

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1-oleoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine

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DL-p-hydroxyphenyl lactic acid

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1-(sn-glycero-3-phospho)-1D-myo-inositol

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phenyl hydrogen sulfate

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N-acetylneuraminic acid 9-phosphate

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5'-inosine monophosphate

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1-stearoyl-lysophosphatidylcholine

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1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate

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bis-beta-D-fructofuranose 1,2':2,3'-dianhydride

1 reference

N-myristoylsphingosine-1-phosphocholine

1 reference

(S)-2-hydroxystearic acid

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(S)-1-pyrroline-5-carboxylic acid

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PC(16:0/18:3(6Z,9Z,12Z))

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PG(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

1 reference

LysoPC(22:4(7Z,10Z,13Z,16Z))

1 reference

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

1-S-[(1Z)-N-(sulfooxy)ethanimidoyl]-1-thio-beta-D-glucopyranose

1 reference

1 reference

N(2)-acetyl-L-ornithine

1 reference

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guanosine monophosphate

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2-Azaniumyl-5-(ethylamino)-5-oxopentanoate

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N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine

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4,4'-methylenebis(2-chloroaniline)

1 reference

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(1S,6S)-6-amino-octahydroindolizin-1-yl acetate

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5-guanidino-2-oxopentanoic acid

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N-hexadecanoylsphingosine

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N(omega)-phospho-L-arginine

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N-ribosylnicotinamide

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2,2,4-trihydroxybutanoic acid

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(2R)-1-aminopropan-2-ol

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4-trimethylammoniobutanoate

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2-Amino-4-((carboxycarbonyl)amino)butanoic acid, (2S)-

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1-aminocyclopropanecarboxylic acid

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9,10-dihydroxystearic acid

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N-docosanoylsphingosine

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1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine

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S,S-(2-Hydroxyethyl)Thiocysteine

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O-propanoylcarnitine (internal charge)

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PG(18:0/22:5(4Z,7Z,10Z,13Z,16Z))

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PS(18:2(9Z,12Z)/18:2(9Z,12Z))

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6-amino-2-oxohexanoic acid

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3-phosphoglyceraldehyde

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indole-3-pyruvic acid

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2-(alpha-D-mannosyl)-D-glyceric acid

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(2E)-2-hydroxycinnamic acid

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3-(4-hydroxyphenyl)pyruvic acid

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sedoheptulose 7-phosphate

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(4S,5S)-5'-methylthioadenosine

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11-aminoundecanoic acid

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gamma-glutamyl-gamma-aminobutyraldehyde

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1 reference

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N-octadecanoyl-4-hydroxysphinganine

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3,4-dihydroxyphenylacetaldehyde

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1 reference

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1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

1-docosapentaenoyl-sn-glycero-3-phosphocholine

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N(pros)-methyl-L-histidine

1 reference

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PG(16:0/20:4(5Z,8Z,11Z,14Z))

1 reference

1,2-dilinoleoyl-sn-glycero-3-phosphate

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(2E,4E,8E,10E)-dodecatetraenedioic acid

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1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine

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1,2-di-O-pentadecanoyl-sn-glycero-3-phosphocholine

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1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine

1 reference

2-methyl-L-tryptophan

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2-phosphinomethylmalic acid

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D-glucuronolactone (open form)

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C18:1DH Sphingomyelin

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N-acetyl-D-glucosamine 6-phosphate

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(2S)-2-hydroxy-2-methyl-3-oxobutanoic acid

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glycodeoxycholic acid

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N(6)-[(indol-3-yl)acetyl]-L-lysine

1 reference

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D-glucitol 6-phosphate

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N-docosanoylsphingosine-1-phosphocholine

1 reference

1-tetradecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-phosphocholine

1 reference

1 reference

1 reference

1-[(9Z)-hexadecenoyl]-sn-glycero-3-phosphocholine

1 reference

3alpha,12alpha-Dihydroxy-5beta-chol-6-en-24-oic acid

1 reference

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1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine

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cyclo(DeltaAla-L-Val)

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N(6)-(dimethylallyl)adenosine 5'-triphosphate

1 reference

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lysophosphatidic acid 0:0/18:2(9Z,12Z)

1 reference

1 reference

1 reference

1 reference

1 reference

1-linoleoyl-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

PE(18:1(9Z)/18:2(9Z,12Z))

1 reference

1 reference

PC(14:1(9Z)/16:1(9Z))

1 reference

1 reference

PS(16:0/18:2(9Z,12Z))

1 reference

CDP-choline (neutral charge)

N-Acetyl-D-Glucosamine

1 reference

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1-(11Z-octadecenyl)-sn-glycero-3-phosphocholine

1 reference

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3-phospho-D-glyceric acid

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Phosphoenolpyruvic acid

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phosphocholine cation

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alpha,alpha-trehalose 6-phosphate

1 reference

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5-hydroxyvaleric acid

1 reference

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L-methionine (RS)-S-oxide

1 reference

dehydrodeoxycoformycin

1 reference

4-(methylthio)-2-oxobutanoic acid

1 reference

N-icosanoylsphingosine-1-phosphocholine

1 reference

PC(18:1(9Z)/20:3(5Z,8Z,11Z))

1 reference

1 reference

L-cysteine sulphinic acid

1 reference

2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol

1 reference

(13Z)-8-hydroxyoctadecene-9,11-diynoic acid

1 reference

1 reference

1 reference

2-acetamido-5-oxopentanoic acid

1 reference

1 reference

glycine betaine aldehyde

1 reference

1 reference

N-hexadecanoylphytosphingosine

1 reference

N-methylethanolamine phosphate

1 reference

1 reference

1,2-dilinoleoyl-sn-glycero-3-phospho-1D-myo-inositol

1 reference

1-[(9Z)-hexadecenoyl]-2-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine

1 reference

1 reference

1 reference

PC(P-16:0/18:2(9Z,12Z))

1 reference

PG(18:0/22:4(7Z,10Z,13Z,16Z))

N-palmitoylsphingomyelin

1 reference

1 reference

1 reference

1 reference

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16-hydroxypalmitic acid

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

2-linoleoyl-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

1 reference

N-octadecanoylsphingosine

1 reference

1 reference

(24R)-1alpha,24-dihydroxy-22-oxavitamin D3

1 reference

1 reference

Sphinganine-1-phosphocholine

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

3-methyl-2-oxobutyric acid

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

6-acetamido-2-oxohexanoic acid

1 reference

cytidine monophosphate

1 reference

(S)-2-azetidinecarboxylic acid

N(1)-acetylspermidine

1 reference

1 reference

1 reference

1 reference

S-methyl-L-methionine

1 reference

DG(16:1(9Z)/20:1(11Z)/0:0)

1 reference

1-arachidonoyl-sn-glycero-3-phosphocholine

1 reference

1 reference

1-Stearoyl-2-docosahexaenoyl-sn-glycerol

1 reference

1 reference

N-methylimidazoleacetic acid

1 reference

(+/-)-acetylcarnitine

1 reference

1-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine

1 reference

1-stearoyl-2-linoleoyl-sn-glycero-3-phosphate

1 reference

1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine

1 reference

PC(18:2(9Z,12Z)/18:1(9Z))

1 reference

1 reference

1 reference

1 reference

1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine

1 reference

1 reference

N-undecylundecan-1-amine

1 reference

1,2-dioleoyl-sn-glycero-3-phosphocholine

1 reference

1 reference

PA(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

1 reference

PG(16:0/20:3(5Z,8Z,11Z))

1 reference

N-oleoylsphingosine-1-phosphocholine

1 reference

N-hexadecanoylsphingosine 1-phosphate

1 reference

1 reference

N-(13Z-docosenoyl)-sphing-4-enine-1-phosphocholine

1 reference

PA(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

1 reference

1 reference

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-D-myo-inositol

1 reference

4,7-dioxooctanoic acid

1 reference

PC(16:0/18:3(9Z,12Z,15Z))

1 reference

1,2-dilinoleoyl-sn-glycero-3-phosphocholine

1 reference

N-(4-aminohepta-5,6-dien-1-yl)guanidine

1 reference

6

Michael P Barrett

0 references

Isabel Vincent

object named as

Isabel M Vincent

1

0 references

Karl V Burgess

object named as

Karl Burgess

3

0 references

Darren J Creek

object named as

Darren J Creek

2

0 references

author name string

Debra J Woods

4

0 references

Richard J S Burchmore

5

0 references

Michael P Barrett

full work available at URL

6

0 references

language of work or name

English

0 references

publication date

2012

0 references

https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001618&type=printable

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1371/journal.pntd.0001618?email=unpaywall_01@example.com

published in

PLoS Neglected Tropical Diseases

0 references

volume

6

0 references

page(s)

e1618

0 references

issue

5

0 references

copyright license

Creative Commons Attribution 2.5 Generic

0 references

on focus list of Wikimedia project

0 references

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1371/journal.pntd.0001618?email=unpaywall_01@example.com

access restriction status

open access

1 reference

inferred from online access status

cites work

Systems-scale analysis reveals pathways involved in cellular response to methamphetamine

1 reference

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A molecular mechanism for eflornithine resistance in African trypanosomes

19 March 2017

1 reference

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NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness

19 March 2017

1 reference

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Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

19 March 2017

1 reference

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Bioinformatic analysis of an unusual gene-enzyme relationship in the arginine biosynthetic pathway among marine gamma proteobacteria: implications concerning the formation of N-acetylated intermediates in prokaryotes

19 March 2017

1 reference

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X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine

19 March 2017

1 reference

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Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

19 March 2017

1 reference

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Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites

19 March 2017

1 reference

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XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

19 March 2017

1 reference

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Metabolomic analysis of trypanosomatid protozoa

7 April 2017

1 reference

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Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry

29 September 2017

1 reference

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Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction

29 September 2017

1 reference

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PeakML/mzMatch: a file format, Java library, R library, and tool-chain for mass spectrometry data analysis

29 September 2017

1 reference

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Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites.

29 September 2017

1 reference

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Inhibition profile of Leishmania mexicana arginase reveals differences with human arginase I.

29 September 2017

1 reference

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Trypanosoma brucei: a model micro-organism to study eukaryotic phospholipid biosynthesis

29 September 2017

1 reference

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The distribution of nifurtimox across the healthy and trypanosome-infected murine blood-brain and blood-cerebrospinal fluid barriers

29 September 2017

1 reference

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Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis

29 September 2017

1 reference

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Metabolomic systems biology of trypanosomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Central carbon metabolism of Leishmania parasites

29 September 2017

1 reference

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RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Discrimination of modes of action of antifungal substances by use of metabolic footprinting.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae

29 September 2017

1 reference

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Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage

29 September 2017

1 reference

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ACETYLORNITHINE DELTA-TRANSAMINASE. PARTIAL PURIFICATION AND REPRESSION BEHAVIOR

29 September 2017

1 reference

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Genomic organisation and transcription characterisation of the gene encoding Leishmania (Leishmania) amazonensis arginase and its protein structure prediction.

29 September 2017

1 reference

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The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

29 September 2017

1 reference

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Arsenical-resistant trypanosomes lack an unusual adenosine transporter

29 September 2017

1 reference

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Recent research on the biological activity of suramin

29 September 2017

1 reference

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Cultivation of bloodstream Trypanosoma brucei

29 September 2017

1 reference

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Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

29 September 2017

1 reference

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Automated mode-of-action detection by metabolic profiling.

29 September 2017

1 reference

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Fluorescence polarization studies on Escherichia coli membrane stability and its relation to the resistance of the cell to freeze-thawing. II. Stabilization of the membranes by polyamines.

2 June 2018

1 reference

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Human African trypanosomiasis

2 June 2018

2 references

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001618

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341325

Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?

27 November 2018

1 reference

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In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.

21 January 2018

1 reference

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Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules

21 January 2018

1 reference

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An effect of parasite-encoded arginase on the outcome of murine cutaneous leishmaniasis

21 January 2018

1 reference

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Biochemical and biophysical properties of a highly active recombinant arginase from Leishmania (Leishmania) amazonensis and subcellular localization of native enzyme

21 January 2018

1 reference

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Trypanosoma brucei brucei: characterization of an ODC null bloodstream form mutant and the action of alpha-difluoromethylornithine.

21 January 2018

1 reference

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Transketolase in Trypanosoma brucei

21 January 2018

1 reference

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Transport of methionine in Trypanosoma brucei brucei

21 January 2018

1 reference

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GC-MS-based metabolomics reveals mechanism of action for hydrazine induced hepatotoxicity in rats

21 January 2018

1 reference

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27 November 2018

Pentamidine: a review

1 reference

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Necessity of antibody response in the treatment of African trypanosomiasis with alpha-difluoromethylornithine

27 November 2018

1 reference

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In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

27 November 2018

1 reference

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The enzymes of the classical pentose phosphate pathway display differential activities in procyclic and bloodstream forms of Trypanosoma brucei

21 January 2018

1 reference

12 December 2020

Polyamines as a defense mechanism against lipoperoxidation in Trypanosoma cruzi

1 reference

12 December 2020

Hydrogen peroxide metabolism in Trypanosoma brucei

1 reference

12 December 2020

Trypanosoma cruzi: Oxidative stress induces arginine kinase expression

1 reference

12 December 2020

2009 FDA drug approvals

1 reference

12 December 2020

10.1371/JOURNAL.PNTD.0001618

Identifiers

DOI

1 reference

3644474

3644474

1 reference

1 reference

1 reference