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Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
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scholarly article
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PubMed
PubMed ID
19948730
retrieved
24 January 2017
title
Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos
(English)
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PubMed
PubMed ID
19948730
retrieved
24 January 2017
main subject
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
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GOA release 2020-03-11
mitochondrion
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author name string
Schuyler T. Pike
series ordinal
1
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PubMed
PubMed ID
19948730
retrieved
24 January 2017
Rashmi Rajendra
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
19948730
retrieved
24 January 2017
Karen Artzt
series ordinal
3
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PubMed
PubMed ID
19948730
retrieved
24 January 2017
Dean R. Appling
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
19948730
retrieved
24 January 2017
language of work or name
English
0 references
publication date
12 February 2010
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PubMed
PubMed ID
19948730
retrieved
24 January 2017
published in
Journal of Biological Chemistry
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stated in
PubMed
PubMed ID
19948730
retrieved
24 January 2017
volume
285
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stated in
PubMed
PubMed ID
19948730
retrieved
24 January 2017
page(s)
4612–4620
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stated in
PubMed
PubMed ID
19948730
retrieved
24 January 2017
issue
7
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stated in
PubMed
PubMed ID
19948730
retrieved
24 January 2017
cites work
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency
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PubMed Central
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19 March 2017
Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase
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PubMed Central
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19 March 2017
Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.
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19 March 2017
DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2
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19 March 2017
Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development
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Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls
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19 March 2017
The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR
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19 March 2017
Crooked tail (Cd) models human folate-responsive neural tube defects
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PubMed Central
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19 March 2017
Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae
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19 March 2017
Metabolic role of cytoplasmic isozymes of 5,10-methylenetetrahydrofolate dehydrogenase in Saccharomyces cerevisiae
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PubMed Central
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19 March 2017
NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells
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PubMed Central
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19 March 2017
Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase
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19 March 2017
Rat C1-tetrahydrofolate synthase. cDNA isolation, tissue-specific levels of the mRNA, and expression of the protein in yeast
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19 March 2017
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
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19 March 2017
Production of 1-carbon units from glycine is extensive in healthy men and women
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29 September 2017
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism
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PubMed Central
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29 September 2017
Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoform
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PubMed Central
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29 September 2017
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice
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PubMed Central
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29 September 2017
Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts
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PubMed Central
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29 September 2017
Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway
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PubMed Central
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29 September 2017
Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase
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PubMed Central
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29 September 2017
NAD- and NADP-dependent mitochondrially targeted methylenetetrahydrofolate dehydrogenase-cyclohydrolases can rescue mthfd2 null fibroblasts
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PubMed Central
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29 September 2017
Mouse models of neural tube defects: investigating preventive mechanisms.
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29 September 2017
Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria
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PubMed Central
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29 September 2017
Induction of the neural crest and the opportunities of life on the edge.
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29 September 2017
Molecular mechanisms of neural crest induction
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PubMed Central
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29 September 2017
A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma
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29 September 2017
Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs
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PubMed Central
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29 September 2017
Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses
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PubMed Central
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29 September 2017
Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development
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PubMed Central
reference URL
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29 September 2017
Hypothesis: folate-responsive neural tube defects and neurocristopathies
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PubMed Central
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29 September 2017
Characterization of the enzyme complex involving the folate-requiring enzymes of de novo purine biosynthesis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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29 September 2017
Molecular genetic analysis of Saccharomyces cerevisiae C1-tetrahydrofolate synthase mutants reveals a noncatalytic function of the ADE3 gene product and an additional folate-dependent enzyme
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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29 September 2017
Compartmentation of folate-mediated one-carbon metabolism in eukaryotes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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29 September 2017
Formyl-methenyl-methylenetetrahydrofolate synthetase (combined): Correlation of enzymic activities with limited proteolytic degradation of the protein from yeast
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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29 September 2017
Formyl-methenyl-methylenetetrahydrofolate synthetase from rabbit liver (combined). Evidence for a single site in the conversion of 5,10-methylenetetrahydrofolate to 10-formyltetrahydrofolate
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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29 September 2017
Dynamic changes in the epigenomic state and nuclear organization of differentiating mouse embryonic stem cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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2 June 2018
NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase from ascites tumor cells. Purification and properties.
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PubMed Central
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2 June 2018
Isolation and characterization of cDNA clones encoding the murine NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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2 June 2018
Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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2 June 2018
Biosynthesis of phosphoserine in the Methanococcales
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
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27 November 2018
The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth
1 reference
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PubMed Central
reference URL
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27 November 2018
Embryonic development of folate binding protein-1 (Folbp1) knockout mice: Effects of the chemical form, dose, and timing of maternal folate supplementation.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
retrieved
27 November 2018
The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
retrieved
27 November 2018
Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
retrieved
27 November 2018
Primed, constant infusion with [2H3]serine allows in vivo kinetic measurement of serine turnover, homocysteine remethylation, and transsulfuration processes in human one-carbon metabolism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
retrieved
27 November 2018
Quantitative study in vivo of methionine cycle in humans using [methyl-2H3]- and [1-13C]methionine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836066
retrieved
27 November 2018
13C NMR analysis of intercompartmental flow of one-carbon units into choline and purines in Saccharomyces cerevisiae
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19948730
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19948730
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19948730
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19948730
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase in transformed cells is a mitochondrial enzyme
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19948730
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19948730
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
13C NMR analysis of the use of alternative donors to the tetrahydrofolate-dependent one-carbon pools in Saccharomyces cerevisiae
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19948730
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1074/JBC.M109.079855
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PMCID
2836066
0 references
PubMed ID
19948730
1 reference
stated in
PubMed
PubMed ID
19948730
retrieved
24 January 2017
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