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Autoubiquitylation of the V(D)J recombinase protein RAG1
scientific journal article
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scholarly article
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PubMed
PubMed ID
14671314
retrieved
24 January 2017
title
Autoubiquitylation of the V(D)J recombinase protein RAG1
(English)
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stated in
PubMed
PubMed ID
14671314
retrieved
24 January 2017
main subject
Recombination activating 1
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GOA release 2020-03-11
author name string
Jessica M. Jones
series ordinal
1
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PubMed
PubMed ID
14671314
retrieved
24 January 2017
Martin Gellert
series ordinal
2
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PubMed
PubMed ID
14671314
retrieved
24 January 2017
language of work or name
English
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publication date
23 December 2003
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stated in
PubMed
PubMed ID
14671314
retrieved
24 January 2017
published in
Proceedings of the National Academy of Sciences of the United States of America
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stated in
PubMed
PubMed ID
14671314
retrieved
24 January 2017
volume
100
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stated in
PubMed
PubMed ID
14671314
retrieved
24 January 2017
page(s)
15446–15451
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stated in
PubMed
PubMed ID
14671314
retrieved
24 January 2017
issue
26
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stated in
PubMed
PubMed ID
14671314
retrieved
24 January 2017
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ImageQuant
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Europe PubMed Central
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11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC307587/fullTextXML
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inferred from PubMed Central ID database lookup
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The RAG1 N-terminal domain is an E3 ubiquitin ligase
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PubMed Central
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19 March 2017
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
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PubMed Central
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19 March 2017
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
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19 March 2017
Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins
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19 March 2017
Structure of a BRCA1-BARD1 heterodimeric RING-RING complex
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19 March 2017
Mechanisms underlying ubiquitination
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PubMed Central
reference URL
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19 March 2017
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
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PubMed Central
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19 March 2017
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases
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PubMed Central
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19 March 2017
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Crossref
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22 April 2017
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
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PubMed Central
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19 March 2017
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
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PubMed Central
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19 March 2017
Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
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19 March 2017
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
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19 March 2017
Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
19 March 2017
Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
19 March 2017
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
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19 March 2017
The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
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19 March 2017
Expression and V(D)J recombination activity of mutated RAG-1 proteins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
19 March 2017
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
19 March 2017
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
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19 March 2017
SCF and Cullin/Ring H2-based ubiquitin ligases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
7 April 2017
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
7 April 2017
The C-terminal portion of RAG2 protects against transposition in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Regulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
V(D)J recombination: RAG proteins, repair factors, and regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
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29 September 2017
Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
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29 September 2017
V(D)J recombination: links to transposition and double-strand break repair.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
N-terminal RAG1 frameshift mutations in Omenn's syndrome: internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Substrate targeting in the ubiquitin system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Complementation of V(D)J recombination deficiency in RAG-1(-/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Analysis of regions of RAG-2 important for V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Definition of a core region of RAG-2 that is functional in V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Cell cycle regulation of V(D)J recombination-activating protein RAG-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Initiation of V(D)J recombination in a cell-free system.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
The V(D)J recombination activating gene, RAG-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
29 September 2017
Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
2 June 2018
Formation and resolution of double-strand break intermediates in V(D)J rearrangement
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
2 June 2018
RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.2637012100
retrieved
21 January 2018
Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.2637012100
retrieved
21 January 2018
Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.2637012100
retrieved
21 January 2018
V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.2637012100
retrieved
21 January 2018
N-terminal truncated human RAG1 proteins can direct T-cell receptor but not immunoglobulin gene rearrangements.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307587
retrieved
27 November 2018
A zinc-binding domain involved in the dimerization of RAG1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.2637012100
retrieved
21 January 2018
Identifiers
DOI
10.1073/PNAS.2637012100
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4496755
ADS bibcode
2003PNAS..10015446J
0 references
OpenCitations bibliographic resource ID
4496755
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4496755
PMCID
307587
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4496755
PubMed ID
14671314
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4496755
ResearchGate publication ID
8963697
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