(Q28509338)

24 January 2017

title

NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation (English)

1 reference

Nuclear factor of activated T-cells, cytoplasmic 3

24 January 2017

0 references

1 reference

GOA release 2020-03-11

author name string

Sergio de Frutos

1

1 reference

24 January 2017

Rhyannon Spangler

2

1 reference

24 January 2017

Dominique Alò

3

1 reference

24 January 2017

Laura V. González Bosc

4

1 reference

24 January 2017

language of work or name

English

0 references

publication date

18 May 2007

1 reference

Journal of Biological Chemistry

24 January 2017

published in

1 reference

24 January 2017

volume

282

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24 January 2017

issue

20

1 reference

24 January 2017

page(s)

15081–15089

1 reference

Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth

24 January 2017

cites work

1 reference

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Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription

19 March 2017

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

19 March 2017

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Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

The transcription factor NFAT4 is involved in the generation and survival of T cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Transcription factors of the NFAT family: regulation and function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Transcriptional regulation by calcium, calcineurin, and NFAT

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

An overview of pulmonary arterial hypertension: risks, pathogenesis, clinical manifestations, and management

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

TRPC3 channels confer cellular memory of recent neuromuscular activity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

NFAT regulation in smooth muscle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

NFAT signaling in vertebrate development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

NFAT4 movement in native smooth muscle. A role for differential Ca(2+) signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Altered pulmonary vasoreactivity in the chronically hypoxic lung

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Mechanisms of structural remodeling in chronic pulmonary hypertension

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Perspectives on oxygen sensing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Molecular control of vascular smooth muscle cell differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Molecular regulation of smooth muscle cell differentiation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Circulating endothelin-1 concentrations in patients with chronic hypoxia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Regulation of differentiation of vascular smooth muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Smooth muscle cell hypertrophy versus hyperplasia in hypertension

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Ultrastructural features of the distended pulmonary arteries of the normal rat

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Hypoxia induces differentiation of pulmonary artery adventitial fibroblasts into myofibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

alpha-smooth-muscle actin and microvascular precursor smooth-muscle cells in pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Modulation of angiotensin II receptor expression during development and regression of hypoxic pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell su

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Effects of ET-A receptor blockade on eNOS gene expression in chronic hypoxic rat lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Plasma endothelin-1 immunoreactivity in asthmatic children.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

A novel and selective endothelin ET(A) receptor antagonist YM598 prevents the development of chronic hypoxia-induced pulmonary hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Cyclosporin A inhibits hypoxia-induced pulmonary hypertension and right ventricle hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Activation of NFATc3 Down-regulates the β1 Subunit of Large Conductance, Calcium-activated K+Channels in Arterial Smooth Muscle and Contributes to Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

Pressure-induced smooth muscle cell depolarization in pulmonary arteries from control and chronically hypoxic rats does not cause myogenic vasoconstriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702679200

NFATc3 regulates Kv2.1 expression in arterial smooth muscle.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Contribution of oxygen radicals to altered NO-dependent pulmonary vasodilation in acute and chronic hypoxia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Maintained upregulation of pulmonary eNOS gene and protein expression during recovery from chronic hypoxia.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754407

Increased lung preproET-1 and decreased ETB-receptor gene expression in fetal pulmonary hypertension

27 November 2018

1 reference

12 December 2020

Change of level and expression of endothelin-1 in the lungs of rats with hypoxic pulmonary hypertension

1 reference

12 December 2020

Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension

1 reference

12 December 2020

Segmental vasodilatory effectiveness of inhaled NO in lungs from chronically hypoxic rats

1 reference

12 December 2020

Localization and distribution of endothelin receptor subtypes in pulmonary vasculature of normal and hypoxia-exposed rats

1 reference

12 December 2020

Enhanced ET(A)-receptor-mediated inhibition of K(v) channels in hypoxic hypertensive rat pulmonary artery myocytes

1 reference

12 December 2020

Evidence that Galpha(q)-coupled receptor-induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells

1 reference

12 December 2020

Expression of pulmonary vascular angiotensin-converting enzyme in primary and secondary plexiform pulmonary hypertension

1 reference

12 December 2020

Partial HIF-1alpha deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

1 reference

12 December 2020

Effects of chronic hypoxia on the circulating and pancreatic renin-angiotensin system

1 reference

12 December 2020

Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: role of calcium, endothelium-derived nitric oxide, and cGMP-dependent protein kinase

1 reference

12 December 2020

Actin and tropomyosin variants in smooth muscles. Dependence on tissue type

1 reference

12 December 2020

Primary pulmonary hypertension in a patient with systemic-onset juvenile arthritis

1 reference

12 December 2020

Pulmonary arterial hypertension responsive to immunosuppressive therapy in systemic lupus erythematosus

1 reference

12 December 2020

Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M702679200

0 references

PMC publication ID

2754407

0 references

1 reference